Plasma concentrations of persistent organic pollutants and pancreatic cancer risk

Miquel Porta; Magda Gasull; José Pumarega; Hannu Kiviranta; Panu Rantakokko; Ole Raaschou-Nielsen; Ingvar A Bergdahl; Torkjel Manning Sandanger; Antoni Agudo; Charlotta Rylander; Therese Haugdahl Nøst; Carolina Donat-Vargas; Dagfinn Aune; Alicia K Heath; Lluís Cirera; Fernando Goñi-Irigoyen; Juan Alguacil; Àlex Giménez-Robert; Anne Tjønneland; Malin Sund; Kim Overvad; Francesca Romana Mancini; Vinciane Rebours; Marie-Christine Boutron-Ruault; Rudolf Kaaks; Matthias B Schulze; Antonia Trichopoulou; Domenico Palli; Sara Grioni; Rosario Tumino; Alessio Naccarati; Salvatore Panico; Roel Vermeulen; J Ramón Quirós; Miguel Rodríguez-Barranco; Sandra M Colorado-Yohar; María-Dolores Chirlaque; Eva Ardanaz; Nick Wareham; Tim Key; Mattias Johansson; Neil Murphy; Pietro Ferrari; Inge Huybrechts; Veronique Chajes; Carlos Alberto Gonzalez; Bas Bueno- de-Mesquita; Marc Gunter; Elisabete Weiderpass; Elio Riboli; Eric J Duell; Verena Katzke; Paolo Vineis

doi:10.1093/ije/dyab115

Plasma concentrations of persistent organic pollutants and pancreatic cancer risk

Miquel Porta, Magda Gasull, José Pumarega, Hannu Kiviranta, Panu Rantakokko, Ole Raaschou-Nielsen, Ingvar A Bergdahl, Torkjel Manning Sandanger, Antoni Agudo, Charlotta Rylander, Therese Haugdahl Nøst, Carolina Donat-Vargas, Dagfinn Aune, Alicia K Heath, Lluís Cirera, Fernando Goñi-Irigoyen, Juan Alguacil, Àlex Giménez-Robert, Anne Tjønneland, Malin SundKim Overvad, Francesca Romana Mancini, Vinciane Rebours, Marie-Christine Boutron-Ruault, Rudolf Kaaks, Matthias B Schulze, Antonia Trichopoulou, Domenico Palli, Sara Grioni, Rosario Tumino, Alessio Naccarati, Salvatore Panico, Roel Vermeulen, J Ramón Quirós, Miguel Rodríguez-Barranco, Sandra M Colorado-Yohar, María-Dolores Chirlaque, Eva Ardanaz, Nick Wareham, Tim Key, Mattias Johansson, Neil Murphy, Pietro Ferrari, Inge Huybrechts, Veronique Chajes, Carlos Alberto Gonzalez, Bas Bueno- de-Mesquita, Marc Gunter, Elisabete Weiderpass, Elio Riboli, Eric J Duell, Verena Katzke, Paolo Vineis

Research output: Contribution to journal › Article › Scientific › peer-review

Abstract

Findings and limitations of previous studies on persistent organic pollutants (POPs) and pancreatic cancer risk support conducting further research in prospective cohorts.We conducted a prospective case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Participants were 513 pancreatic cancer cases and 1020 matched controls. Concentrations of 22 POPs were measured in plasma collected at baseline.Some associations were observed at higher concentrations of p, p’-DDT, trans-nonachlor, β-hexachlorocyclohexane and the sum of six organochlorine pesticides and of 16 POPs. The odds ratio (OR) for the upper quartile of trans-nonachlor was 1.55 (95\.06-2.26; P for trend = 0.025). Associations were stronger in the groups predefined as most valid (participants having fasted \gt;6 h, with microscopic diagnostic confirmation, normal weight, and never smokers), and as most relevant (follow-up ≥10 years). Among participants having fasted \gt;6 h, the ORs were relevant for 10 of 11 exposures. Higher ORs were also observed among cases with microscopic confirmation than in cases with a clinical diagnosis, and among normal-weight participants than in the rest of participants. Among participants with a follow-up ≥10 years, estimates were higher than in participants with a shorter follow-up (for trans-nonachlor: OR = 2.14, 1.01 to 4.53, P for trend = 0.035). Overall, trans-nonachlor, three PCBs and the two sums of POPs were the exposures most clearly associated with pancreatic cancer risk.Individually or in combination, most of the 22 POPs analysed did not or only moderately increased the risk of pancreatic cancer.

Original language	English
Journal	International Journal of Epidemiology
Volume	51
Issue number	2
Pages (from-to)	479–490
Number of pages	12
ISSN	0300-5771
DOIs	https://doi.org/10.1093/ije/dyab115
Publication status	Published - Apr 2022
MoE publication type	A1 Journal article-refereed

Fields of Science

3121 General medicine, internal medicine and other clinical medicine

Access to Document

10.1093/ije/dyab115

dyab115Final published version, 542 KBLicence: CC BY-NC

Cite this

Porta, M., Gasull, M., Pumarega, J., Kiviranta, H., Rantakokko, P., Raaschou-Nielsen, O., Bergdahl, I. A., Sandanger, T. M., Agudo, A., Rylander, C., Nøst, T. H., Donat-Vargas, C., Aune, D., Heath, A. K., Cirera, L., Goñi-Irigoyen, F., Alguacil, J., Giménez-Robert, À., Tjønneland, A., ... Vineis, P. (2022). Plasma concentrations of persistent organic pollutants and pancreatic cancer risk. International Journal of Epidemiology, 51(2), 479–490. https://doi.org/10.1093/ije/dyab115

@article{5948d14bef4742d3a37f8b57d8c5984d,

title = "Plasma concentrations of persistent organic pollutants and pancreatic cancer risk",

abstract = "Findings and limitations of previous studies on persistent organic pollutants (POPs) and pancreatic cancer risk support conducting further research in prospective cohorts.We conducted a prospective case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Participants were 513 pancreatic cancer cases and 1020 matched controls. Concentrations of 22 POPs were measured in plasma collected at baseline.Some associations were observed at higher concentrations of p, p{\textquoteright}-DDT, trans-nonachlor, β-hexachlorocyclohexane and the sum of six organochlorine pesticides and of 16 POPs. The odds ratio (OR) for the upper quartile of trans-nonachlor was 1.55 (95\textbackslash{}.06-2.26; P for trend = 0.025). Associations were stronger in the groups predefined as most valid (participants having fasted \textbackslash{}gt;6 h, with microscopic diagnostic confirmation, normal weight, and never smokers), and as most relevant (follow-up ≥10 years). Among participants having fasted \textbackslash{}gt;6 h, the ORs were relevant for 10 of 11 exposures. Higher ORs were also observed among cases with microscopic confirmation than in cases with a clinical diagnosis, and among normal-weight participants than in the rest of participants. Among participants with a follow-up ≥10 years, estimates were higher than in participants with a shorter follow-up (for trans-nonachlor: OR = 2.14, 1.01 to 4.53, P for trend = 0.035). Overall, trans-nonachlor, three PCBs and the two sums of POPs were the exposures most clearly associated with pancreatic cancer risk.Individually or in combination, most of the 22 POPs analysed did not or only moderately increased the risk of pancreatic cancer.",

keywords = "3121 General medicine, internal medicine and other clinical medicine",

author = "Miquel Porta and Magda Gasull and Jos{\'e} Pumarega and Hannu Kiviranta and Panu Rantakokko and Ole Raaschou-Nielsen and Bergdahl, \{Ingvar A\} and Sandanger, \{Torkjel Manning\} and Antoni Agudo and Charlotta Rylander and N{\o}st, \{Therese Haugdahl\} and Carolina Donat-Vargas and Dagfinn Aune and Heath, \{Alicia K\} and Llu{\'i}s Cirera and Fernando Go{\~n}i-Irigoyen and Juan Alguacil and {\`A}lex Gim{\'e}nez-Robert and Anne Tj{\o}nneland and Malin Sund and Kim Overvad and Mancini, \{Francesca Romana\} and Vinciane Rebours and Marie-Christine Boutron-Ruault and Rudolf Kaaks and Schulze, \{Matthias B\} and Antonia Trichopoulou and Domenico Palli and Sara Grioni and Rosario Tumino and Alessio Naccarati and Salvatore Panico and Roel Vermeulen and Quir{\'o}s, \{J Ram{\'o}n\} and Miguel Rodr{\'i}guez-Barranco and Colorado-Yohar, \{Sandra M\} and Mar{\'i}a-Dolores Chirlaque and Eva Ardanaz and Nick Wareham and Tim Key and Mattias Johansson and Neil Murphy and Pietro Ferrari and Inge Huybrechts and Veronique Chajes and Gonzalez, \{Carlos Alberto\} and de-Mesquita, \{Bas Bueno-\} and Marc Gunter and Elisabete Weiderpass and Elio Riboli and Duell, \{Eric J\} and Verena Katzke and Paolo Vineis",

note = "dyab115",

year = "2022",

month = apr,

doi = "10.1093/ije/dyab115",

language = "English",

volume = "51",

pages = "479–490",

journal = "International Journal of Epidemiology",

issn = "0300-5771",

publisher = "Oxford University Press",

number = "2",

}

Porta, M, Gasull, M, Pumarega, J, Kiviranta, H, Rantakokko, P, Raaschou-Nielsen, O, Bergdahl, IA, Sandanger, TM, Agudo, A, Rylander, C, Nøst, TH, Donat-Vargas, C, Aune, D, Heath, AK, Cirera, L, Goñi-Irigoyen, F, Alguacil, J, Giménez-Robert, À, Tjønneland, A, Sund, M, Overvad, K, Mancini, FR, Rebours, V, Boutron-Ruault, M-C, Kaaks, R, Schulze, MB, Trichopoulou, A, Palli, D, Grioni, S, Tumino, R, Naccarati, A, Panico, S, Vermeulen, R, Quirós, JR, Rodríguez-Barranco, M, Colorado-Yohar, SM, Chirlaque, M-D, Ardanaz, E, Wareham, N, Key, T, Johansson, M, Murphy, N, Ferrari, P, Huybrechts, I, Chajes, V, Gonzalez, CA, de-Mesquita, BB, Gunter, M, Weiderpass, E, Riboli, E, Duell, EJ, Katzke, V & Vineis, P 2022, 'Plasma concentrations of persistent organic pollutants and pancreatic cancer risk', International Journal of Epidemiology, vol. 51, no. 2, pp. 479–490. https://doi.org/10.1093/ije/dyab115

TY - JOUR

T1 - Plasma concentrations of persistent organic pollutants and pancreatic cancer risk

AU - Porta, Miquel

AU - Gasull, Magda

AU - Pumarega, José

AU - Kiviranta, Hannu

AU - Rantakokko, Panu

AU - Raaschou-Nielsen, Ole

AU - Bergdahl, Ingvar A

AU - Sandanger, Torkjel Manning

AU - Agudo, Antoni

AU - Rylander, Charlotta

AU - Nøst, Therese Haugdahl

AU - Donat-Vargas, Carolina

AU - Aune, Dagfinn

AU - Heath, Alicia K

AU - Cirera, Lluís

AU - Goñi-Irigoyen, Fernando

AU - Alguacil, Juan

AU - Giménez-Robert, Àlex

AU - Tjønneland, Anne

AU - Sund, Malin

AU - Overvad, Kim

AU - Mancini, Francesca Romana

AU - Rebours, Vinciane

AU - Boutron-Ruault, Marie-Christine

AU - Kaaks, Rudolf

AU - Schulze, Matthias B

AU - Trichopoulou, Antonia

AU - Palli, Domenico

AU - Grioni, Sara

AU - Tumino, Rosario

AU - Naccarati, Alessio

AU - Panico, Salvatore

AU - Vermeulen, Roel

AU - Quirós, J Ramón

AU - Rodríguez-Barranco, Miguel

AU - Colorado-Yohar, Sandra M

AU - Chirlaque, María-Dolores

AU - Ardanaz, Eva

AU - Wareham, Nick

AU - Key, Tim

AU - Johansson, Mattias

AU - Murphy, Neil

AU - Ferrari, Pietro

AU - Huybrechts, Inge

AU - Chajes, Veronique

AU - Gonzalez, Carlos Alberto

AU - de-Mesquita, Bas Bueno-

AU - Gunter, Marc

AU - Weiderpass, Elisabete

AU - Riboli, Elio

AU - Duell, Eric J

AU - Katzke, Verena

AU - Vineis, Paolo

N1 - dyab115

PY - 2022/4

Y1 - 2022/4

N2 - Findings and limitations of previous studies on persistent organic pollutants (POPs) and pancreatic cancer risk support conducting further research in prospective cohorts.We conducted a prospective case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Participants were 513 pancreatic cancer cases and 1020 matched controls. Concentrations of 22 POPs were measured in plasma collected at baseline.Some associations were observed at higher concentrations of p, p’-DDT, trans-nonachlor, β-hexachlorocyclohexane and the sum of six organochlorine pesticides and of 16 POPs. The odds ratio (OR) for the upper quartile of trans-nonachlor was 1.55 (95\.06-2.26; P for trend = 0.025). Associations were stronger in the groups predefined as most valid (participants having fasted \gt;6 h, with microscopic diagnostic confirmation, normal weight, and never smokers), and as most relevant (follow-up ≥10 years). Among participants having fasted \gt;6 h, the ORs were relevant for 10 of 11 exposures. Higher ORs were also observed among cases with microscopic confirmation than in cases with a clinical diagnosis, and among normal-weight participants than in the rest of participants. Among participants with a follow-up ≥10 years, estimates were higher than in participants with a shorter follow-up (for trans-nonachlor: OR = 2.14, 1.01 to 4.53, P for trend = 0.035). Overall, trans-nonachlor, three PCBs and the two sums of POPs were the exposures most clearly associated with pancreatic cancer risk.Individually or in combination, most of the 22 POPs analysed did not or only moderately increased the risk of pancreatic cancer.

AB - Findings and limitations of previous studies on persistent organic pollutants (POPs) and pancreatic cancer risk support conducting further research in prospective cohorts.We conducted a prospective case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Participants were 513 pancreatic cancer cases and 1020 matched controls. Concentrations of 22 POPs were measured in plasma collected at baseline.Some associations were observed at higher concentrations of p, p’-DDT, trans-nonachlor, β-hexachlorocyclohexane and the sum of six organochlorine pesticides and of 16 POPs. The odds ratio (OR) for the upper quartile of trans-nonachlor was 1.55 (95\.06-2.26; P for trend = 0.025). Associations were stronger in the groups predefined as most valid (participants having fasted \gt;6 h, with microscopic diagnostic confirmation, normal weight, and never smokers), and as most relevant (follow-up ≥10 years). Among participants having fasted \gt;6 h, the ORs were relevant for 10 of 11 exposures. Higher ORs were also observed among cases with microscopic confirmation than in cases with a clinical diagnosis, and among normal-weight participants than in the rest of participants. Among participants with a follow-up ≥10 years, estimates were higher than in participants with a shorter follow-up (for trans-nonachlor: OR = 2.14, 1.01 to 4.53, P for trend = 0.035). Overall, trans-nonachlor, three PCBs and the two sums of POPs were the exposures most clearly associated with pancreatic cancer risk.Individually or in combination, most of the 22 POPs analysed did not or only moderately increased the risk of pancreatic cancer.

KW - 3121 General medicine, internal medicine and other clinical medicine

U2 - 10.1093/ije/dyab115

DO - 10.1093/ije/dyab115

M3 - Article

SN - 0300-5771

VL - 51

SP - 479

EP - 490

JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

IS - 2

ER -