Plasma levels of haemostatic factors in patients with pulmonary embolism on admission and seven months later

Markus Sane, Marit Graner, Jari A. Laukkanen, Veli-Pekka Harjola, Pekka Mustonen

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Introduction: With the exception of D-dimer, not much is known about the plasma levels of haemostatic factors during acute venous thromboembolism (VTE) compared to their basic levels in a stable phase. The goal of this study was to examine how plasma levels of factor V, VIII, XIIIa, von Willebrand factor antigen (vWF:Ag), fibrinogen, thrombomodulin evolve from the point of diagnosis of acute VTE to the end of standard treatment period.

Methods: Sixty-three consecutive patients (mean 57, range 18-86 years, 33 females) with acute pulmonary embolism (PE) were included. Laboratory samples were collected upon arrival (acute phase) and seven months later (stable phase). Fifteen similar aged individuals served as controls.

Results: Plasma levels of factor XIIIa (87.5% vs 117.7%, P

Conclusion: This study confirms the concept of FXIIIa consumption during acute phase of VTE by showing its intraindividual normalization during the follow-up. vWF:Ag, known to be associated with the risk of VTE, was constantly elevated in the majority of the patients. Soluble thrombomodulin levels were lower in acute phase compared to stable phase, a finding which significance needs to be evaluated in the future.

Original languageEnglish
JournalInternational Journal of Laboratory Hematology (Print Edition)
Volume40
Issue number1
Pages (from-to)66-71
Number of pages6
ISSN1751-5521
DOIs
Publication statusPublished - Feb 2018
MoE publication typeA1 Journal article-refereed

Fields of Science

  • 3121 General medicine, internal medicine and other clinical medicine

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