Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways

Max Lam, W. David Hill, Joey W. Trampush, Jin Yu, Emma Knowles, Gail Davies, Eli Stahl, Laura Huckins, David C. Liewald, Srdjan Djurovic, Ingrid Melle, Kjetil Sundet, Andrea Christoforou, Ivar Reinvang, Pamela DeRosse, Astri J. Lundervold, Vidar M. Steen, Thomas Espeseth, Katri Räikkönen, Elisabeth WidenAarno Palotie, Johan G. Eriksson, Ina Giegling, Bettina Konte, Annette M. Hartmann, Panos Roussos, Stella Giakoumaki, Katherine E. Burdick, Antony Payton, William Ollier, Ornit Chiba-Falek, Deborah K. Attix, Anna C. Need, Elizabeth T. Cirulli, Aristotle N. Voineskos, Nikos C. Stefanis, Dimitrios Avramopoulos, Alex Hatzimanolis, Dan E. Arking, Nikolaos Smyrnis, Robert M. Bilder, Nelson A. Freimer, Tyrone D. Cannon, Edythe London, Russell A. Poldrack, Fred W. Sabb, Eliza Congdon, Emily Drabant Conley, Matthew A. Scult, Dwight Dickinson, Richard E. Straub, Gary Donohoe, Derek Morris, Aiden Corvin, Michael Gill, Ahmad R. Hariri, Daniel R. Weinberger, Neil Pendleton, Panos Bitsios, Dan Rujescu, Jari Lahti, Stephanie Le Hellard, Matthew C. Keller, Ole A. Andreassen, Ian J. Deary, David C. Glahn, Anil K. Malhotra, Todd Lencz

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalAmerican Journal of Human Genetics
Volume105
Issue number2
Pages (from-to)334-350
Number of pages17
ISSN0002-9297
DOIs
Publication statusPublished - Aug 2019
MoE publication typeA1 Journal article-refereed

Fields of Science

  • GENOME-WIDE ASSOCIATION
  • DE-NOVO MUTATIONS
  • DNA-DAMAGE
  • 1ST-EPISODE SCHIZOPHRENIA
  • BIPOLAR DISORDER
  • GENE-EXPRESSION
  • POLYGENIC RISK
  • CHD8
  • AUTISM
  • LOCI
  • 3111 Biomedicine
  • 1184 Genetics, developmental biology, physiology

Cite this

Lam, Max ; Hill, W. David ; Trampush, Joey W. ; Yu, Jin ; Knowles, Emma ; Davies, Gail ; Stahl, Eli ; Huckins, Laura ; Liewald, David C. ; Djurovic, Srdjan ; Melle, Ingrid ; Sundet, Kjetil ; Christoforou, Andrea ; Reinvang, Ivar ; DeRosse, Pamela ; Lundervold, Astri J. ; Steen, Vidar M. ; Espeseth, Thomas ; Räikkönen, Katri ; Widen, Elisabeth ; Palotie, Aarno ; Eriksson, Johan G. ; Giegling, Ina ; Konte, Bettina ; Hartmann, Annette M. ; Roussos, Panos ; Giakoumaki, Stella ; Burdick, Katherine E. ; Payton, Antony ; Ollier, William ; Chiba-Falek, Ornit ; Attix, Deborah K. ; Need, Anna C. ; Cirulli, Elizabeth T. ; Voineskos, Aristotle N. ; Stefanis, Nikos C. ; Avramopoulos, Dimitrios ; Hatzimanolis, Alex ; Arking, Dan E. ; Smyrnis, Nikolaos ; Bilder, Robert M. ; Freimer, Nelson A. ; Cannon, Tyrone D. ; London, Edythe ; Poldrack, Russell A. ; Sabb, Fred W. ; Congdon, Eliza ; Conley, Emily Drabant ; Scult, Matthew A. ; Dickinson, Dwight ; Straub, Richard E. ; Donohoe, Gary ; Morris, Derek ; Corvin, Aiden ; Gill, Michael ; Hariri, Ahmad R. ; Weinberger, Daniel R. ; Pendleton, Neil ; Bitsios, Panos ; Rujescu, Dan ; Lahti, Jari ; Le Hellard, Stephanie ; Keller, Matthew C. ; Andreassen, Ole A. ; Deary, Ian J. ; Glahn, David C. ; Malhotra, Anil K. ; Lencz, Todd. / Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways. In: American Journal of Human Genetics. 2019 ; Vol. 105, No. 2. pp. 334-350.
@article{934ebdf4889c441b8964ec26f06b636e,
title = "Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways",
keywords = "GENOME-WIDE ASSOCIATION, DE-NOVO MUTATIONS, DNA-DAMAGE, 1ST-EPISODE SCHIZOPHRENIA, BIPOLAR DISORDER, GENE-EXPRESSION, POLYGENIC RISK, CHD8, AUTISM, LOCI, 3111 Biomedicine, 1184 Genetics, developmental biology, physiology",
author = "Max Lam and Hill, {W. David} and Trampush, {Joey W.} and Jin Yu and Emma Knowles and Gail Davies and Eli Stahl and Laura Huckins and Liewald, {David C.} and Srdjan Djurovic and Ingrid Melle and Kjetil Sundet and Andrea Christoforou and Ivar Reinvang and Pamela DeRosse and Lundervold, {Astri J.} and Steen, {Vidar M.} and Thomas Espeseth and Katri R{\"a}ikk{\"o}nen and Elisabeth Widen and Aarno Palotie and Eriksson, {Johan G.} and Ina Giegling and Bettina Konte and Hartmann, {Annette M.} and Panos Roussos and Stella Giakoumaki and Burdick, {Katherine E.} and Antony Payton and William Ollier and Ornit Chiba-Falek and Attix, {Deborah K.} and Need, {Anna C.} and Cirulli, {Elizabeth T.} and Voineskos, {Aristotle N.} and Stefanis, {Nikos C.} and Dimitrios Avramopoulos and Alex Hatzimanolis and Arking, {Dan E.} and Nikolaos Smyrnis and Bilder, {Robert M.} and Freimer, {Nelson A.} and Cannon, {Tyrone D.} and Edythe London and Poldrack, {Russell A.} and Sabb, {Fred W.} and Eliza Congdon and Conley, {Emily Drabant} and Scult, {Matthew A.} and Dwight Dickinson and Straub, {Richard E.} and Gary Donohoe and Derek Morris and Aiden Corvin and Michael Gill and Hariri, {Ahmad R.} and Weinberger, {Daniel R.} and Neil Pendleton and Panos Bitsios and Dan Rujescu and Jari Lahti and {Le Hellard}, Stephanie and Keller, {Matthew C.} and Andreassen, {Ole A.} and Deary, {Ian J.} and Glahn, {David C.} and Malhotra, {Anil K.} and Todd Lencz",
year = "2019",
month = "8",
doi = "10.1016/j.ajhg.2019.06.012",
language = "English",
volume = "105",
pages = "334--350",
journal = "American Journal of Human Genetics",
issn = "0002-9297",
publisher = "Cell Press",
number = "2",

}

Lam, M, Hill, WD, Trampush, JW, Yu, J, Knowles, E, Davies, G, Stahl, E, Huckins, L, Liewald, DC, Djurovic, S, Melle, I, Sundet, K, Christoforou, A, Reinvang, I, DeRosse, P, Lundervold, AJ, Steen, VM, Espeseth, T, Räikkönen, K, Widen, E, Palotie, A, Eriksson, JG, Giegling, I, Konte, B, Hartmann, AM, Roussos, P, Giakoumaki, S, Burdick, KE, Payton, A, Ollier, W, Chiba-Falek, O, Attix, DK, Need, AC, Cirulli, ET, Voineskos, AN, Stefanis, NC, Avramopoulos, D, Hatzimanolis, A, Arking, DE, Smyrnis, N, Bilder, RM, Freimer, NA, Cannon, TD, London, E, Poldrack, RA, Sabb, FW, Congdon, E, Conley, ED, Scult, MA, Dickinson, D, Straub, RE, Donohoe, G, Morris, D, Corvin, A, Gill, M, Hariri, AR, Weinberger, DR, Pendleton, N, Bitsios, P, Rujescu, D, Lahti, J, Le Hellard, S, Keller, MC, Andreassen, OA, Deary, IJ, Glahn, DC, Malhotra, AK & Lencz, T 2019, 'Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways', American Journal of Human Genetics, vol. 105, no. 2, pp. 334-350. https://doi.org/10.1016/j.ajhg.2019.06.012

Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways. / Lam, Max; Hill, W. David; Trampush, Joey W.; Yu, Jin; Knowles, Emma; Davies, Gail; Stahl, Eli; Huckins, Laura; Liewald, David C.; Djurovic, Srdjan; Melle, Ingrid; Sundet, Kjetil; Christoforou, Andrea; Reinvang, Ivar; DeRosse, Pamela; Lundervold, Astri J.; Steen, Vidar M.; Espeseth, Thomas; Räikkönen, Katri; Widen, Elisabeth; Palotie, Aarno; Eriksson, Johan G.; Giegling, Ina; Konte, Bettina; Hartmann, Annette M.; Roussos, Panos; Giakoumaki, Stella; Burdick, Katherine E.; Payton, Antony; Ollier, William; Chiba-Falek, Ornit; Attix, Deborah K.; Need, Anna C.; Cirulli, Elizabeth T.; Voineskos, Aristotle N.; Stefanis, Nikos C.; Avramopoulos, Dimitrios; Hatzimanolis, Alex; Arking, Dan E.; Smyrnis, Nikolaos; Bilder, Robert M.; Freimer, Nelson A.; Cannon, Tyrone D.; London, Edythe; Poldrack, Russell A.; Sabb, Fred W.; Congdon, Eliza; Conley, Emily Drabant; Scult, Matthew A.; Dickinson, Dwight; Straub, Richard E.; Donohoe, Gary; Morris, Derek; Corvin, Aiden; Gill, Michael; Hariri, Ahmad R.; Weinberger, Daniel R.; Pendleton, Neil; Bitsios, Panos; Rujescu, Dan; Lahti, Jari; Le Hellard, Stephanie; Keller, Matthew C.; Andreassen, Ole A.; Deary, Ian J.; Glahn, David C.; Malhotra, Anil K.; Lencz, Todd.

In: American Journal of Human Genetics, Vol. 105, No. 2, 08.2019, p. 334-350.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways

AU - Lam, Max

AU - Hill, W. David

AU - Trampush, Joey W.

AU - Yu, Jin

AU - Knowles, Emma

AU - Davies, Gail

AU - Stahl, Eli

AU - Huckins, Laura

AU - Liewald, David C.

AU - Djurovic, Srdjan

AU - Melle, Ingrid

AU - Sundet, Kjetil

AU - Christoforou, Andrea

AU - Reinvang, Ivar

AU - DeRosse, Pamela

AU - Lundervold, Astri J.

AU - Steen, Vidar M.

AU - Espeseth, Thomas

AU - Räikkönen, Katri

AU - Widen, Elisabeth

AU - Palotie, Aarno

AU - Eriksson, Johan G.

AU - Giegling, Ina

AU - Konte, Bettina

AU - Hartmann, Annette M.

AU - Roussos, Panos

AU - Giakoumaki, Stella

AU - Burdick, Katherine E.

AU - Payton, Antony

AU - Ollier, William

AU - Chiba-Falek, Ornit

AU - Attix, Deborah K.

AU - Need, Anna C.

AU - Cirulli, Elizabeth T.

AU - Voineskos, Aristotle N.

AU - Stefanis, Nikos C.

AU - Avramopoulos, Dimitrios

AU - Hatzimanolis, Alex

AU - Arking, Dan E.

AU - Smyrnis, Nikolaos

AU - Bilder, Robert M.

AU - Freimer, Nelson A.

AU - Cannon, Tyrone D.

AU - London, Edythe

AU - Poldrack, Russell A.

AU - Sabb, Fred W.

AU - Congdon, Eliza

AU - Conley, Emily Drabant

AU - Scult, Matthew A.

AU - Dickinson, Dwight

AU - Straub, Richard E.

AU - Donohoe, Gary

AU - Morris, Derek

AU - Corvin, Aiden

AU - Gill, Michael

AU - Hariri, Ahmad R.

AU - Weinberger, Daniel R.

AU - Pendleton, Neil

AU - Bitsios, Panos

AU - Rujescu, Dan

AU - Lahti, Jari

AU - Le Hellard, Stephanie

AU - Keller, Matthew C.

AU - Andreassen, Ole A.

AU - Deary, Ian J.

AU - Glahn, David C.

AU - Malhotra, Anil K.

AU - Lencz, Todd

PY - 2019/8

Y1 - 2019/8

KW - GENOME-WIDE ASSOCIATION

KW - DE-NOVO MUTATIONS

KW - DNA-DAMAGE

KW - 1ST-EPISODE SCHIZOPHRENIA

KW - BIPOLAR DISORDER

KW - GENE-EXPRESSION

KW - POLYGENIC RISK

KW - CHD8

KW - AUTISM

KW - LOCI

KW - 3111 Biomedicine

KW - 1184 Genetics, developmental biology, physiology

U2 - 10.1016/j.ajhg.2019.06.012

DO - 10.1016/j.ajhg.2019.06.012

M3 - Article

VL - 105

SP - 334

EP - 350

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

SN - 0002-9297

IS - 2

ER -