Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies

Mashaal Sohail, Robert M. Maier, Andrea Ganna, Alex Bloemendal, Alicia R. Martin, Michael C. Turchin, Charleston W. K. Chiang, Joel Hirschhorn, Mark J. Daly, Nick Patterson, Benjamin Neale, Iain Mathieson, David Reich, Shamil R. Sunyaev

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
Article number39702
JournaleLife
Volume8
Number of pages17
ISSN2050-084X
DOIs
Publication statusPublished - 21 Mar 2019
MoE publication typeA1 Journal article-refereed

Fields of Science

  • GENETIC RISK
  • POPULATION-STRUCTURE
  • SELECTION
  • DISEASE
  • PREDICTION
  • HISTORY
  • 3111 Biomedicine
  • 1184 Genetics, developmental biology, physiology

Cite this

Sohail, M., Maier, R. M., Ganna, A., Bloemendal, A., Martin, A. R., Turchin, M. C., ... Sunyaev, S. R. (2019). Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies. eLife, 8, [39702]. https://doi.org/10.7554/eLife.39702
Sohail, Mashaal ; Maier, Robert M. ; Ganna, Andrea ; Bloemendal, Alex ; Martin, Alicia R. ; Turchin, Michael C. ; Chiang, Charleston W. K. ; Hirschhorn, Joel ; Daly, Mark J. ; Patterson, Nick ; Neale, Benjamin ; Mathieson, Iain ; Reich, David ; Sunyaev, Shamil R. / Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies. In: eLife. 2019 ; Vol. 8.
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title = "Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies",
keywords = "GENETIC RISK, POPULATION-STRUCTURE, SELECTION, DISEASE, PREDICTION, HISTORY, 3111 Biomedicine, 1184 Genetics, developmental biology, physiology",
author = "Mashaal Sohail and Maier, {Robert M.} and Andrea Ganna and Alex Bloemendal and Martin, {Alicia R.} and Turchin, {Michael C.} and Chiang, {Charleston W. K.} and Joel Hirschhorn and Daly, {Mark J.} and Nick Patterson and Benjamin Neale and Iain Mathieson and David Reich and Sunyaev, {Shamil R.}",
year = "2019",
month = "3",
day = "21",
doi = "10.7554/eLife.39702",
language = "English",
volume = "8",
journal = "eLife",
issn = "2050-084X",
publisher = "ELIFE SCIENCES PUBLICATIONS LTD",

}

Sohail, M, Maier, RM, Ganna, A, Bloemendal, A, Martin, AR, Turchin, MC, Chiang, CWK, Hirschhorn, J, Daly, MJ, Patterson, N, Neale, B, Mathieson, I, Reich, D & Sunyaev, SR 2019, 'Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies', eLife, vol. 8, 39702. https://doi.org/10.7554/eLife.39702

Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies. / Sohail, Mashaal; Maier, Robert M.; Ganna, Andrea; Bloemendal, Alex; Martin, Alicia R.; Turchin, Michael C.; Chiang, Charleston W. K.; Hirschhorn, Joel; Daly, Mark J.; Patterson, Nick; Neale, Benjamin; Mathieson, Iain; Reich, David; Sunyaev, Shamil R.

In: eLife, Vol. 8, 39702, 21.03.2019.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies

AU - Sohail, Mashaal

AU - Maier, Robert M.

AU - Ganna, Andrea

AU - Bloemendal, Alex

AU - Martin, Alicia R.

AU - Turchin, Michael C.

AU - Chiang, Charleston W. K.

AU - Hirschhorn, Joel

AU - Daly, Mark J.

AU - Patterson, Nick

AU - Neale, Benjamin

AU - Mathieson, Iain

AU - Reich, David

AU - Sunyaev, Shamil R.

PY - 2019/3/21

Y1 - 2019/3/21

KW - GENETIC RISK

KW - POPULATION-STRUCTURE

KW - SELECTION

KW - DISEASE

KW - PREDICTION

KW - HISTORY

KW - 3111 Biomedicine

KW - 1184 Genetics, developmental biology, physiology

U2 - 10.7554/eLife.39702

DO - 10.7554/eLife.39702

M3 - Article

VL - 8

JO - eLife

JF - eLife

SN - 2050-084X

M1 - 39702

ER -