Porous silicon nanoparticles for nanomedicine: preparation and biomedical applications

Research output: Contribution to journalReview ArticleScientificpeer-review

Abstract

The research on porous silicon (PSi) materials for biomedical applications has expanded greatly since the early studies of Leigh Canham more than 25 years ago. Currently, PSi nanoparticles are receiving growing attention from the scientific biomedical community. These nanostructured materials have emerged as promising multifunctional and versatile platforms for nanomedicine in drug delivery, diagnostics and therapy. The outstanding properties of PSi, including excellent in vivo biocompatibility and biodegradability, have led to many applications of PSi for delivery of therapeutic agents. In this review, we highlight current advances and recent efforts on PSi nanoparticles regarding the production properties, efficient drug delivery, multidrug delivery, permeation across biological barriers, biosafety and in vivo tracking for biomedical applications. The constant boost on successful preclinical in vivo data reported so far makes this the ‘golden age’ for PSi, which is expected to finally be translated into the clinic in the near future.
Original languageEnglish
JournalNanomedicine
Volume9
Issue number4
Pages (from-to)535-554
Number of pages20
ISSN1743-5889
DOIs
Publication statusPublished - 2014
MoE publication typeA2 Review article in a scientific journal

Fields of Science

  • 317 Pharmacy
  • mesoporous silicon nanoparticles

Cite this

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title = "Porous silicon nanoparticles for nanomedicine: preparation and biomedical applications",
abstract = "The research on porous silicon (PSi) materials for biomedical applications has expanded greatly since the early studies of Leigh Canham more than 25 years ago. Currently, PSi nanoparticles are receiving growing attention from the scientific biomedical community. These nanostructured materials have emerged as promising multifunctional and versatile platforms for nanomedicine in drug delivery, diagnostics and therapy. The outstanding properties of PSi, including excellent in vivo biocompatibility and biodegradability, have led to many applications of PSi for delivery of therapeutic agents. In this review, we highlight current advances and recent efforts on PSi nanoparticles regarding the production properties, efficient drug delivery, multidrug delivery, permeation across biological barriers, biosafety and in vivo tracking for biomedical applications. The constant boost on successful preclinical in vivo data reported so far makes this the ‘golden age’ for PSi, which is expected to finally be translated into the clinic in the near future.",
keywords = "317 Pharmacy, mesoporous silicon nanoparticles",
author = "Santos, {H{\'e}lder A.} and Ermei M{\"a}kil{\"a} and Anu Airaksinen and Bimbo, {Luis Maria} and Jouni Hirvonen",
year = "2014",
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language = "English",
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journal = "Nanomedicine",
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Porous silicon nanoparticles for nanomedicine : preparation and biomedical applications. / Santos, Hélder A.; Mäkilä, Ermei; Airaksinen, Anu; Bimbo, Luis Maria; Hirvonen, Jouni .

In: Nanomedicine, Vol. 9, No. 4, 2014, p. 535-554.

Research output: Contribution to journalReview ArticleScientificpeer-review

TY - JOUR

T1 - Porous silicon nanoparticles for nanomedicine

T2 - preparation and biomedical applications

AU - Santos, Hélder A.

AU - Mäkilä, Ermei

AU - Airaksinen, Anu

AU - Bimbo, Luis Maria

AU - Hirvonen, Jouni

PY - 2014

Y1 - 2014

N2 - The research on porous silicon (PSi) materials for biomedical applications has expanded greatly since the early studies of Leigh Canham more than 25 years ago. Currently, PSi nanoparticles are receiving growing attention from the scientific biomedical community. These nanostructured materials have emerged as promising multifunctional and versatile platforms for nanomedicine in drug delivery, diagnostics and therapy. The outstanding properties of PSi, including excellent in vivo biocompatibility and biodegradability, have led to many applications of PSi for delivery of therapeutic agents. In this review, we highlight current advances and recent efforts on PSi nanoparticles regarding the production properties, efficient drug delivery, multidrug delivery, permeation across biological barriers, biosafety and in vivo tracking for biomedical applications. The constant boost on successful preclinical in vivo data reported so far makes this the ‘golden age’ for PSi, which is expected to finally be translated into the clinic in the near future.

AB - The research on porous silicon (PSi) materials for biomedical applications has expanded greatly since the early studies of Leigh Canham more than 25 years ago. Currently, PSi nanoparticles are receiving growing attention from the scientific biomedical community. These nanostructured materials have emerged as promising multifunctional and versatile platforms for nanomedicine in drug delivery, diagnostics and therapy. The outstanding properties of PSi, including excellent in vivo biocompatibility and biodegradability, have led to many applications of PSi for delivery of therapeutic agents. In this review, we highlight current advances and recent efforts on PSi nanoparticles regarding the production properties, efficient drug delivery, multidrug delivery, permeation across biological barriers, biosafety and in vivo tracking for biomedical applications. The constant boost on successful preclinical in vivo data reported so far makes this the ‘golden age’ for PSi, which is expected to finally be translated into the clinic in the near future.

KW - 317 Pharmacy

KW - mesoporous silicon nanoparticles

U2 - 10.2217/nnm.13.223

DO - 10.2217/nnm.13.223

M3 - Review Article

VL - 9

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JF - Nanomedicine

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