Postoperative CEA is a better prognostic marker than CA19-9, hCGβ or TATI after resection of colorectal liver metastases

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Liver metastases of colorectal cancer can be operated with a curative intent in selected cases. However, more than half of the patients have a recurrence. The aim of this study was to evaluate the prognostic and predictive value of carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), human chorionic gonadotropin ? (hCG?) and tumour-associated trypsin-inhibitor (TATI) in colorectal cancer patients before and 3?months after resection of liver metastases. Marker concentrations were determined in blood samples from 168 colorectal cancer patients, who underwent liver resection between the years 1998 and 2007 at Helsinki University Hospital, Finland. The samples were taken before and 3?months after curative resection. Increased concentrations of CEA (>5?µg/L) and hCG? (>1?pmol/L) 3?months after liver resection correlated with recurrence and impaired overall survival and increased CA19-9 (>26?kU/L) with impaired overall survival, but postoperative TATI was not prognostic. Preoperatively elevated CEA and CA19-9 correlated with impaired overall survival, but not with recurrence. Neither preoperative hCG? nor TATI was prognostic. In conclusion, CEA is a useful prognostic marker, when measured 3?months after resection of colorectal liver metastases. CA19-9 also has prognostic significance and may have additional value.
Original languageEnglish
Article number1010428317752944
JournalTumor Biology
Volume40
Issue number1
Number of pages9
ISSN1010-4283
DOIs
Publication statusPublished - 1 Jan 2018
MoE publication typeA1 Journal article-refereed

Fields of Science

  • 3126 Surgery, anesthesiology, intensive care, radiology

Cite this

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title = "Postoperative CEA is a better prognostic marker than CA19-9, hCGβ or TATI after resection of colorectal liver metastases",
abstract = "Liver metastases of colorectal cancer can be operated with a curative intent in selected cases. However, more than half of the patients have a recurrence. The aim of this study was to evaluate the prognostic and predictive value of carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), human chorionic gonadotropin ? (hCG?) and tumour-associated trypsin-inhibitor (TATI) in colorectal cancer patients before and 3?months after resection of liver metastases. Marker concentrations were determined in blood samples from 168 colorectal cancer patients, who underwent liver resection between the years 1998 and 2007 at Helsinki University Hospital, Finland. The samples were taken before and 3?months after curative resection. Increased concentrations of CEA (>5?µg/L) and hCG? (>1?pmol/L) 3?months after liver resection correlated with recurrence and impaired overall survival and increased CA19-9 (>26?kU/L) with impaired overall survival, but postoperative TATI was not prognostic. Preoperatively elevated CEA and CA19-9 correlated with impaired overall survival, but not with recurrence. Neither preoperative hCG? nor TATI was prognostic. In conclusion, CEA is a useful prognostic marker, when measured 3?months after resection of colorectal liver metastases. CA19-9 also has prognostic significance and may have additional value.",
keywords = "3126 Surgery, anesthesiology, intensive care, radiology",
author = "Reetta Peltonen and Pia {\"O}sterlund and Marko Lempinen and Arno Nordin and Ulf-H{\aa}kan Stenman and Helena Isoniemi",
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Postoperative CEA is a better prognostic marker than CA19-9, hCGβ or TATI after resection of colorectal liver metastases. / Peltonen, Reetta; Österlund, Pia; Lempinen, Marko; Nordin, Arno; Stenman, Ulf-Håkan; Isoniemi, Helena.

In: Tumor Biology, Vol. 40, No. 1, 1010428317752944, 01.01.2018.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Postoperative CEA is a better prognostic marker than CA19-9, hCGβ or TATI after resection of colorectal liver metastases

AU - Peltonen, Reetta

AU - Österlund, Pia

AU - Lempinen, Marko

AU - Nordin, Arno

AU - Stenman, Ulf-Håkan

AU - Isoniemi, Helena

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Liver metastases of colorectal cancer can be operated with a curative intent in selected cases. However, more than half of the patients have a recurrence. The aim of this study was to evaluate the prognostic and predictive value of carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), human chorionic gonadotropin ? (hCG?) and tumour-associated trypsin-inhibitor (TATI) in colorectal cancer patients before and 3?months after resection of liver metastases. Marker concentrations were determined in blood samples from 168 colorectal cancer patients, who underwent liver resection between the years 1998 and 2007 at Helsinki University Hospital, Finland. The samples were taken before and 3?months after curative resection. Increased concentrations of CEA (>5?µg/L) and hCG? (>1?pmol/L) 3?months after liver resection correlated with recurrence and impaired overall survival and increased CA19-9 (>26?kU/L) with impaired overall survival, but postoperative TATI was not prognostic. Preoperatively elevated CEA and CA19-9 correlated with impaired overall survival, but not with recurrence. Neither preoperative hCG? nor TATI was prognostic. In conclusion, CEA is a useful prognostic marker, when measured 3?months after resection of colorectal liver metastases. CA19-9 also has prognostic significance and may have additional value.

AB - Liver metastases of colorectal cancer can be operated with a curative intent in selected cases. However, more than half of the patients have a recurrence. The aim of this study was to evaluate the prognostic and predictive value of carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), human chorionic gonadotropin ? (hCG?) and tumour-associated trypsin-inhibitor (TATI) in colorectal cancer patients before and 3?months after resection of liver metastases. Marker concentrations were determined in blood samples from 168 colorectal cancer patients, who underwent liver resection between the years 1998 and 2007 at Helsinki University Hospital, Finland. The samples were taken before and 3?months after curative resection. Increased concentrations of CEA (>5?µg/L) and hCG? (>1?pmol/L) 3?months after liver resection correlated with recurrence and impaired overall survival and increased CA19-9 (>26?kU/L) with impaired overall survival, but postoperative TATI was not prognostic. Preoperatively elevated CEA and CA19-9 correlated with impaired overall survival, but not with recurrence. Neither preoperative hCG? nor TATI was prognostic. In conclusion, CEA is a useful prognostic marker, when measured 3?months after resection of colorectal liver metastases. CA19-9 also has prognostic significance and may have additional value.

KW - 3126 Surgery, anesthesiology, intensive care, radiology

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