Potent Inhibitor of Human Trypsins from the Aeruginosin Family of Natural Products

Muhammad N. Ahmed; Matti Wahlsten; Jouni Jokela; Matthias Nees; Ulf Håkan Stenman; Danillo O. Alvarenga; Tomas Strandin; Kaarina Sivonen; Antti Poso; Perttu Permi; Mikko Metsä-Ketelä; Hannu Koistinen; David P. Fewer

doi:10.1021/acschembio.1c00611

Potent Inhibitor of Human Trypsins from the Aeruginosin Family of Natural Products

Muhammad N. Ahmed, Matti Wahlsten, Jouni Jokela, Matthias Nees, Ulf Håkan Stenman, Danillo O. Alvarenga, Tomas Strandin, Kaarina Sivonen, Antti Poso, Perttu Permi, Mikko Metsä-Ketelä, Hannu Koistinen, David P. Fewer

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	ACS Chemical Biology
Volume	16
Issue number	11
Pages (from-to)	2537-2546
Number of pages	10
ISSN	1554-8929
DOIs	https://doi.org/10.1021/acschembio.1c00611
Publication status	Published - 19 Nov 2021
MoE publication type	A1 Journal article-refereed

Bibliographical note

Funding Information:
We would like to thank A. Löfhjelm and L. Saari for excellent technical assistance. This work was supported by a Sigrid Jusélius Foundation grant to H.K. and the Academy of Finland funding (321809) to T.S. We would also like to thank the Erkko Foundation and Nordforsk Nordic center of Excellency NordAqua (project number #82845) and University of Helsinki’s Doctoral Programme in Microbiology and Biotechnology funding to M.N.A. D.O.A. was supported by a postdoctoral research fellowship from the São Paulo Research Foundation (FAPESP #2018/01563-2). We thank Biocenter Kuopio for the use of their facilities for molecular modeling and MD simulations. We thank the DNA Sequencing and Genomics laboratory, Institute of Biotechnology, University of Helsinki for assistance in sequencing, assembly, and annotation of DNA. We thank the Language Center of University of Helsinki for their help in language revisions.

Publisher Copyright:
©

Fields of Science

116 Chemical sciences

Access to Document

10.1021/acschembio.1c00611Licence: CC BY

TrypsinFinal published version, 6.22 MBLicence: CC BY

Cite this

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title = "Potent Inhibitor of Human Trypsins from the Aeruginosin Family of Natural Products",

keywords = "116 Chemical sciences",

author = "Ahmed, {Muhammad N.} and Matti Wahlsten and Jouni Jokela and Matthias Nees and Stenman, {Ulf H{\aa}kan} and Alvarenga, {Danillo O.} and Tomas Strandin and Kaarina Sivonen and Antti Poso and Perttu Permi and Mikko Mets{\"a}-Ketel{\"a} and Hannu Koistinen and Fewer, {David P.}",

note = "Funding Information: We would like to thank A. L{\"o}fhjelm and L. Saari for excellent technical assistance. This work was supported by a Sigrid Jus{\'e}lius Foundation grant to H.K. and the Academy of Finland funding (321809) to T.S. We would also like to thank the Erkko Foundation and Nordforsk Nordic center of Excellency NordAqua (project number #82845) and University of Helsinki{\textquoteright}s Doctoral Programme in Microbiology and Biotechnology funding to M.N.A. D.O.A. was supported by a postdoctoral research fellowship from the S{\~a}o Paulo Research Foundation (FAPESP #2018/01563-2). We thank Biocenter Kuopio for the use of their facilities for molecular modeling and MD simulations. We thank the DNA Sequencing and Genomics laboratory, Institute of Biotechnology, University of Helsinki for assistance in sequencing, assembly, and annotation of DNA. We thank the Language Center of University of Helsinki for their help in language revisions. Publisher Copyright: {\textcopyright} ",

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doi = "10.1021/acschembio.1c00611",

language = "English",

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T1 - Potent Inhibitor of Human Trypsins from the Aeruginosin Family of Natural Products

AU - Ahmed, Muhammad N.

AU - Wahlsten, Matti

AU - Jokela, Jouni

AU - Nees, Matthias

AU - Stenman, Ulf Håkan

AU - Alvarenga, Danillo O.

AU - Strandin, Tomas

AU - Sivonen, Kaarina

AU - Poso, Antti

AU - Permi, Perttu

AU - Metsä-Ketelä, Mikko

AU - Koistinen, Hannu

AU - Fewer, David P.

N1 - Funding Information: We would like to thank A. Löfhjelm and L. Saari for excellent technical assistance. This work was supported by a Sigrid Jusélius Foundation grant to H.K. and the Academy of Finland funding (321809) to T.S. We would also like to thank the Erkko Foundation and Nordforsk Nordic center of Excellency NordAqua (project number #82845) and University of Helsinki’s Doctoral Programme in Microbiology and Biotechnology funding to M.N.A. D.O.A. was supported by a postdoctoral research fellowship from the São Paulo Research Foundation (FAPESP #2018/01563-2). We thank Biocenter Kuopio for the use of their facilities for molecular modeling and MD simulations. We thank the DNA Sequencing and Genomics laboratory, Institute of Biotechnology, University of Helsinki for assistance in sequencing, assembly, and annotation of DNA. We thank the Language Center of University of Helsinki for their help in language revisions. Publisher Copyright: ©

PY - 2021/11/19

Y1 - 2021/11/19

KW - 116 Chemical sciences

U2 - 10.1021/acschembio.1c00611

DO - 10.1021/acschembio.1c00611

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SP - 2537

EP - 2546

JO - ACS Chemical Biology

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