PPARA: A Novel Genetic Determinant of CYP3A4 In Vitro and In Vivo

Kathrin Klein, Maria Thomas, Stefan Winter, Andreas K. Nussler, Mikko Niemi, Matthias Schwab, Ulrich M. Zanger

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalClinical Pharmacology and Therapeutics
Volume91
Issue number6
Pages (from-to)1044-1052
Number of pages9
ISSN0009-9236
DOIs
Publication statusPublished - 2012
MoE publication typeA1 Journal article-refereed

Fields of Science

  • RECEPTOR RESPONSE ELEMENT
  • PREGNANE-X RECEPTOR
  • HUMAN HEPATOCYTES
  • TRANSCRIPTIONAL REGULATION
  • HUMAN LIVER
  • CYTOCHROME-P450 3A4
  • ENZYME-ACTIVITY
  • EXPRESSION
  • ATORVASTATIN
  • ALPHA
  • 317 Pharmacy

Cite this

Klein, K., Thomas, M., Winter, S., Nussler, A. K., Niemi, M., Schwab, M., & Zanger, U. M. (2012). PPARA: A Novel Genetic Determinant of CYP3A4 In Vitro and In Vivo. Clinical Pharmacology and Therapeutics, 91(6), 1044-1052. https://doi.org/10.1038/clpt.2011.336
Klein, Kathrin ; Thomas, Maria ; Winter, Stefan ; Nussler, Andreas K. ; Niemi, Mikko ; Schwab, Matthias ; Zanger, Ulrich M. / PPARA: A Novel Genetic Determinant of CYP3A4 In Vitro and In Vivo. In: Clinical Pharmacology and Therapeutics. 2012 ; Vol. 91, No. 6. pp. 1044-1052.
@article{7a23d8310d7c4b0583892595920b62fb,
title = "PPARA: A Novel Genetic Determinant of CYP3A4 In Vitro and In Vivo",
keywords = "RECEPTOR RESPONSE ELEMENT, PREGNANE-X RECEPTOR, HUMAN HEPATOCYTES, TRANSCRIPTIONAL REGULATION, HUMAN LIVER, CYTOCHROME-P450 3A4, ENZYME-ACTIVITY, EXPRESSION, ATORVASTATIN, ALPHA, 317 Pharmacy",
author = "Kathrin Klein and Maria Thomas and Stefan Winter and Nussler, {Andreas K.} and Mikko Niemi and Matthias Schwab and Zanger, {Ulrich M.}",
year = "2012",
doi = "10.1038/clpt.2011.336",
language = "English",
volume = "91",
pages = "1044--1052",
journal = "Clinical Pharmacology and Therapeutics",
issn = "0009-9236",
publisher = "Wiley",
number = "6",

}

Klein, K, Thomas, M, Winter, S, Nussler, AK, Niemi, M, Schwab, M & Zanger, UM 2012, 'PPARA: A Novel Genetic Determinant of CYP3A4 In Vitro and In Vivo', Clinical Pharmacology and Therapeutics, vol. 91, no. 6, pp. 1044-1052. https://doi.org/10.1038/clpt.2011.336

PPARA: A Novel Genetic Determinant of CYP3A4 In Vitro and In Vivo. / Klein, Kathrin; Thomas, Maria; Winter, Stefan; Nussler, Andreas K.; Niemi, Mikko; Schwab, Matthias; Zanger, Ulrich M.

In: Clinical Pharmacology and Therapeutics, Vol. 91, No. 6, 2012, p. 1044-1052.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - PPARA: A Novel Genetic Determinant of CYP3A4 In Vitro and In Vivo

AU - Klein, Kathrin

AU - Thomas, Maria

AU - Winter, Stefan

AU - Nussler, Andreas K.

AU - Niemi, Mikko

AU - Schwab, Matthias

AU - Zanger, Ulrich M.

PY - 2012

Y1 - 2012

KW - RECEPTOR RESPONSE ELEMENT

KW - PREGNANE-X RECEPTOR

KW - HUMAN HEPATOCYTES

KW - TRANSCRIPTIONAL REGULATION

KW - HUMAN LIVER

KW - CYTOCHROME-P450 3A4

KW - ENZYME-ACTIVITY

KW - EXPRESSION

KW - ATORVASTATIN

KW - ALPHA

KW - 317 Pharmacy

U2 - 10.1038/clpt.2011.336

DO - 10.1038/clpt.2011.336

M3 - Article

VL - 91

SP - 1044

EP - 1052

JO - Clinical Pharmacology and Therapeutics

JF - Clinical Pharmacology and Therapeutics

SN - 0009-9236

IS - 6

ER -