Production, applications and in vivo fate of drug nanocrystals

Research output: Contribution to journalReview ArticleScientificpeer-review

Abstract

Today, drug nanocrystals are frequently used as a formulation strategy for improving the solubility and dissolution of poorly soluble drug materials. It is well known that when drug particles are in the nanometer size range their dissolution rate and saturated solubility can both be substantially increased. However, turning the superior dissolution in vitro into bioavailability benefits in vivo, can be problematic. Various in vivo conditions, such as changes in pH in the GI tract, as well as rapid transit through the GI tract may cause problems for permeability. Accordingly, after successful nanocrystallization, it is of the utmost importance to perform the formulation studies carefully. In this review, the production of nanocrystals and their most commonly studied delivery routes are discussed, while keeping in mind in vitro in vivo correlation.
Original languageEnglish
JournalJournal of Drug Delivery Science and Technology
Volume34
Pages (from-to)21-31
Number of pages11
ISSN1773-2247
DOIs
Publication statusPublished - 2016
MoE publication typeA2 Review article in a scientific journal

Fields of Science

  • 317 Pharmacy

Cite this

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title = "Production, applications and in vivo fate of drug nanocrystals",
abstract = "Today, drug nanocrystals are frequently used as a formulation strategy for improving the solubility and dissolution of poorly soluble drug materials. It is well known that when drug particles are in the nanometer size range their dissolution rate and saturated solubility can both be substantially increased. However, turning the superior dissolution in vitro into bioavailability benefits in vivo, can be problematic. Various in vivo conditions, such as changes in pH in the GI tract, as well as rapid transit through the GI tract may cause problems for permeability. Accordingly, after successful nanocrystallization, it is of the utmost importance to perform the formulation studies carefully. In this review, the production of nanocrystals and their most commonly studied delivery routes are discussed, while keeping in mind in vitro in vivo correlation.",
keywords = "317 Pharmacy",
author = "Tuomela, {Annika Laura} and Saarinen, {Jukka Kalle Samuel} and Strachan, {Clare Joanna} and Hirvonen, {Jouni Tapio} and Peltonen, {Leena Johanna}",
year = "2016",
doi = "10.1016/j.jddst.2016.02.006",
language = "English",
volume = "34",
pages = "21--31",
journal = "Journal of Drug Delivery Science and Technology",
issn = "1773-2247",
publisher = "Elsevier Scientific Publ. Co",

}

Production, applications and in vivo fate of drug nanocrystals. / Tuomela, Annika Laura; Saarinen, Jukka Kalle Samuel; Strachan, Clare Joanna; Hirvonen, Jouni Tapio; Peltonen, Leena Johanna.

In: Journal of Drug Delivery Science and Technology, Vol. 34, 2016, p. 21-31.

Research output: Contribution to journalReview ArticleScientificpeer-review

TY - JOUR

T1 - Production, applications and in vivo fate of drug nanocrystals

AU - Tuomela, Annika Laura

AU - Saarinen, Jukka Kalle Samuel

AU - Strachan, Clare Joanna

AU - Hirvonen, Jouni Tapio

AU - Peltonen, Leena Johanna

PY - 2016

Y1 - 2016

N2 - Today, drug nanocrystals are frequently used as a formulation strategy for improving the solubility and dissolution of poorly soluble drug materials. It is well known that when drug particles are in the nanometer size range their dissolution rate and saturated solubility can both be substantially increased. However, turning the superior dissolution in vitro into bioavailability benefits in vivo, can be problematic. Various in vivo conditions, such as changes in pH in the GI tract, as well as rapid transit through the GI tract may cause problems for permeability. Accordingly, after successful nanocrystallization, it is of the utmost importance to perform the formulation studies carefully. In this review, the production of nanocrystals and their most commonly studied delivery routes are discussed, while keeping in mind in vitro in vivo correlation.

AB - Today, drug nanocrystals are frequently used as a formulation strategy for improving the solubility and dissolution of poorly soluble drug materials. It is well known that when drug particles are in the nanometer size range their dissolution rate and saturated solubility can both be substantially increased. However, turning the superior dissolution in vitro into bioavailability benefits in vivo, can be problematic. Various in vivo conditions, such as changes in pH in the GI tract, as well as rapid transit through the GI tract may cause problems for permeability. Accordingly, after successful nanocrystallization, it is of the utmost importance to perform the formulation studies carefully. In this review, the production of nanocrystals and their most commonly studied delivery routes are discussed, while keeping in mind in vitro in vivo correlation.

KW - 317 Pharmacy

U2 - 10.1016/j.jddst.2016.02.006

DO - 10.1016/j.jddst.2016.02.006

M3 - Review Article

VL - 34

SP - 21

EP - 31

JO - Journal of Drug Delivery Science and Technology

JF - Journal of Drug Delivery Science and Technology

SN - 1773-2247

ER -