Production of Pure Drug Nanocrystals and Nano Co-crystals by Confinement Methods

Research output: Contribution to journalReview ArticleScientificpeer-review

Abstract

The use of drug nanocrystals in the drug formulation is increasing due to the large number of poorly water-soluble drug compounds synthetized and due to the advantages brought by the nanonization process. The downsizing processes are done using a top-down approach (milling and homogenization currently employed at the industrial level), while the crystallization process is performed by bottom-up techniques (e.g., antisolvent precipitation to the use of supercritical fluids or spray and freeze drying). In addition, the production of nanocrystals in confined environment can be achieved within microfluidics channels. This review analyzes the processes for the preparation of nanocrystals and co-crystals, divided by top-down and bottom-up approaches, together with their combinations. The combination of both strategies merges the favorable features of each process and avoids the disadvantages of single processes. Overall, the applicability of drug nanocrystals is highlighted by the widespread research on the production processes at the engineering, pharmaceutical, and nanotechnology level.
Original languageEnglish
JournalAdvanced Drug Delivery Reviews
Volume131
Pages (from-to)3-21
Number of pages19
ISSN0169-409X
DOIs
Publication statusPublished - Jun 2018
MoE publication typeA2 Review article in a scientific journal

Fields of Science

  • 317 Pharmacy
  • Nanocrystals
  • Co-crystals
  • Drug
  • Top-down
  • Bottom-up
  • Milling
  • Homogenization
  • Microfluidics
  • Supercritical fluids
  • Spray dryer

Cite this

@article{96329711e70745bb9fad12f7547580ed,
title = "Production of Pure Drug Nanocrystals and Nano Co-crystals by Confinement Methods",
abstract = "The use of drug nanocrystals in the drug formulation is increasing due to the large number of poorly water-soluble drug compounds synthetized and due to the advantages brought by the nanonization process. The downsizing processes are done using a top-down approach (milling and homogenization currently employed at the industrial level), while the crystallization process is performed by bottom-up techniques (e.g., antisolvent precipitation to the use of supercritical fluids or spray and freeze drying). In addition, the production of nanocrystals in confined environment can be achieved within microfluidics channels. This review analyzes the processes for the preparation of nanocrystals and co-crystals, divided by top-down and bottom-up approaches, together with their combinations. The combination of both strategies merges the favorable features of each process and avoids the disadvantages of single processes. Overall, the applicability of drug nanocrystals is highlighted by the widespread research on the production processes at the engineering, pharmaceutical, and nanotechnology level.",
keywords = "317 Pharmacy, Nanocrystals, Co-crystals, Drug, Top-down, Bottom-up, Milling, Homogenization, Microfluidics, Supercritical fluids, Spray dryer",
author = "Flavia Fontana and Figueiredo, {Patricia Isabel} and Pei Zhang and Hirvonen, {Jouni Tapio} and Dongfei Liu and {Almeida Santos}, Helder",
year = "2018",
month = "6",
doi = "10.1016/j.addr.2018.05.002",
language = "English",
volume = "131",
pages = "3--21",
journal = "Advanced Drug Delivery Reviews",
issn = "0169-409X",
publisher = "Elsevier Scientific Publ. Co",

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TY - JOUR

T1 - Production of Pure Drug Nanocrystals and Nano Co-crystals by Confinement Methods

AU - Fontana, Flavia

AU - Figueiredo, Patricia Isabel

AU - Zhang, Pei

AU - Hirvonen, Jouni Tapio

AU - Liu, Dongfei

AU - Almeida Santos, Helder

PY - 2018/6

Y1 - 2018/6

N2 - The use of drug nanocrystals in the drug formulation is increasing due to the large number of poorly water-soluble drug compounds synthetized and due to the advantages brought by the nanonization process. The downsizing processes are done using a top-down approach (milling and homogenization currently employed at the industrial level), while the crystallization process is performed by bottom-up techniques (e.g., antisolvent precipitation to the use of supercritical fluids or spray and freeze drying). In addition, the production of nanocrystals in confined environment can be achieved within microfluidics channels. This review analyzes the processes for the preparation of nanocrystals and co-crystals, divided by top-down and bottom-up approaches, together with their combinations. The combination of both strategies merges the favorable features of each process and avoids the disadvantages of single processes. Overall, the applicability of drug nanocrystals is highlighted by the widespread research on the production processes at the engineering, pharmaceutical, and nanotechnology level.

AB - The use of drug nanocrystals in the drug formulation is increasing due to the large number of poorly water-soluble drug compounds synthetized and due to the advantages brought by the nanonization process. The downsizing processes are done using a top-down approach (milling and homogenization currently employed at the industrial level), while the crystallization process is performed by bottom-up techniques (e.g., antisolvent precipitation to the use of supercritical fluids or spray and freeze drying). In addition, the production of nanocrystals in confined environment can be achieved within microfluidics channels. This review analyzes the processes for the preparation of nanocrystals and co-crystals, divided by top-down and bottom-up approaches, together with their combinations. The combination of both strategies merges the favorable features of each process and avoids the disadvantages of single processes. Overall, the applicability of drug nanocrystals is highlighted by the widespread research on the production processes at the engineering, pharmaceutical, and nanotechnology level.

KW - 317 Pharmacy

KW - Nanocrystals

KW - Co-crystals

KW - Drug

KW - Top-down

KW - Bottom-up

KW - Milling

KW - Homogenization

KW - Microfluidics

KW - Supercritical fluids

KW - Spray dryer

U2 - 10.1016/j.addr.2018.05.002

DO - 10.1016/j.addr.2018.05.002

M3 - Review Article

VL - 131

SP - 3

EP - 21

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

SN - 0169-409X

ER -