Abstract
Tongue squamous cell carcinoma (TSCC) has a poor prognosis due to its early metastasis via blood and lymphatic vessels. We performed a systematic review to investigate the prognostic significance of blood microvessel density (MVD) and lymphatic vessel density (LVD) in TSCC patients. We conducted a systematic search in Ovid Medline, Scopus, and Cochrane libraries. All studies that evaluated the prognostic significance of MVD/LVD markers in TSCC were systematically retrieved. Our results showed that MVD/LVD markers, CD31, CD34, CD105, factor VIII, LYVE‐1, and D2‐40 were evaluated in TSCC patients until 28 June 2018. Six out of 13 studies reported markers that were associated with poor prognosis in TSCC. Two out of three studies suggested that a high number of D2‐40+ vessels predicated low overall survival (OS); the third study reported that the ratio of D2‐40+ over factor VIII+ vessels is associated with low OS. Most of the other markers had controversial results for prognostication. We found higher expression of MVD/LVD markers were commonly, but not always, associated with shorter survival in TSCC patients. It is therefore not currently possible to recommend implementation of these markers as reliable prognosticators in clinical practice. More studies (especially for D2‐40) with larger patient cohorts are needed.
Original language | English |
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Journal | Cancer Science |
Volume | 110 |
Issue number | 11 |
Pages (from-to) | 3424-3433 |
Number of pages | 10 |
ISSN | 1347-9032 |
DOIs | |
Publication status | Published - Nov 2019 |
MoE publication type | A2 Review article in a scientific journal |
Fields of Science
- ANGIOGENESIS
- ASSOCIATION
- CD105 EXPRESSION
- DENSITY
- HEAD
- HEPATOCELLULAR-CARCINOMA
- LYMPHANGIOGENESIS
- NODE METASTASIS
- SQUAMOUS-CELL CARCINOMA
- VASCULAR INVASION
- biomarker
- blood microvessel density
- lymphatic vessel density
- prognosis
- tongue squamous cell carcinoma
- 3122 Cancers
- 111 Mathematics