Abstract

Tongue squamous cell carcinoma (TSCC) has a poor prognosis due to its early metastasis via blood and lymphatic vessels. We performed a systematic review to investigate the prognostic significance of blood microvessel density (MVD) and lymphatic vessel density (LVD) in TSCC patients. We conducted a systematic search in Ovid Medline, Scopus, and Cochrane libraries. All studies that evaluated the prognostic significance of MVD/LVD markers in TSCC were systematically retrieved. Our results showed that MVD/LVD markers, CD31, CD34, CD105, factor VIII, LYVE‐1, and D2‐40 were evaluated in TSCC patients until 28 June 2018. Six out of 13 studies reported markers that were associated with poor prognosis in TSCC. Two out of three studies suggested that a high number of D2‐40+ vessels predicated low overall survival (OS); the third study reported that the ratio of D2‐40+ over factor VIII+ vessels is associated with low OS. Most of the other markers had controversial results for prognostication. We found higher expression of MVD/LVD markers were commonly, but not always, associated with shorter survival in TSCC patients. It is therefore not currently possible to recommend implementation of these markers as reliable prognosticators in clinical practice. More studies (especially for D2‐40) with larger patient cohorts are needed.
Original languageEnglish
JournalCancer Science
Volume110
Issue number11
Number of pages10
ISSN1347-9032
DOIs
Publication statusPublished - Nov 2019
MoE publication typeA2 Review article in a scientific journal

Fields of Science

  • ANGIOGENESIS
  • ASSOCIATION
  • CD105 EXPRESSION
  • DENSITY
  • HEAD
  • HEPATOCELLULAR-CARCINOMA
  • LYMPHANGIOGENESIS
  • NODE METASTASIS
  • SQUAMOUS-CELL CARCINOMA
  • VASCULAR INVASION
  • biomarker
  • blood microvessel density
  • lymphatic vessel density
  • prognosis
  • tongue squamous cell carcinoma
  • 3122 Cancers
  • 111 Mathematics

Cite this

@article{0f653b0d3bfd46d38364e59993a7078c,
title = "Prognostic value of blood and lymphatic vessel markers in tongue cancer: A Systematic Review",
abstract = "Tongue squamous cell carcinoma (TSCC) has a poor prognosis due to its early metastasis via blood and lymphatic vessels. We performed a systematic review to investigate the prognostic significance of blood microvessel density (MVD) and lymphatic vessel density (LVD) in TSCC patients. We conducted a systematic search in Ovid Medline, Scopus, and Cochrane libraries. All studies that evaluated the prognostic significance of MVD/LVD markers in TSCC were systematically retrieved. Our results showed that MVD/LVD markers, CD31, CD34, CD105, factor VIII, LYVE‐1, and D2‐40 were evaluated in TSCC patients until 28 June 2018. Six out of 13 studies reported markers that were associated with poor prognosis in TSCC. Two out of three studies suggested that a high number of D2‐40+ vessels predicated low overall survival (OS); the third study reported that the ratio of D2‐40+ over factor VIII+ vessels is associated with low OS. Most of the other markers had controversial results for prognostication. We found higher expression of MVD/LVD markers were commonly, but not always, associated with shorter survival in TSCC patients. It is therefore not currently possible to recommend implementation of these markers as reliable prognosticators in clinical practice. More studies (especially for D2‐40) with larger patient cohorts are needed.",
keywords = "ANGIOGENESIS, ASSOCIATION, CD105 EXPRESSION, DENSITY, HEAD, HEPATOCELLULAR-CARCINOMA, LYMPHANGIOGENESIS, NODE METASTASIS, SQUAMOUS-CELL CARCINOMA, VASCULAR INVASION, biomarker, blood microvessel density, lymphatic vessel density, prognosis, tongue squamous cell carcinoma, 3122 Cancers, 111 Mathematics",
author = "Rabeia Almahmoudi and Merimaija Kasanen and Meri Sievil{\"a}inen and Abdelhakim Salem and Matti Pirinen and Tuula Salo and Ahmed Al-Samadi",
year = "2019",
month = "11",
doi = "10.1111/cas.14189",
language = "English",
volume = "110",
journal = "Cancer Science",
issn = "1347-9032",
publisher = "WILEY-BLACKWELL PUBLISHING JAPAN",
number = "11",

}

Prognostic value of blood and lymphatic vessel markers in tongue cancer : A Systematic Review. / Almahmoudi, Rabeia; Kasanen, Merimaija; Sieviläinen, Meri; Salem, Abdelhakim; Pirinen, Matti; Salo, Tuula; Al-Samadi, Ahmed.

In: Cancer Science, Vol. 110, No. 11, 11.2019.

Research output: Contribution to journalReview ArticleScientificpeer-review

TY - JOUR

T1 - Prognostic value of blood and lymphatic vessel markers in tongue cancer

T2 - A Systematic Review

AU - Almahmoudi, Rabeia

AU - Kasanen, Merimaija

AU - Sieviläinen, Meri

AU - Salem, Abdelhakim

AU - Pirinen, Matti

AU - Salo, Tuula

AU - Al-Samadi, Ahmed

PY - 2019/11

Y1 - 2019/11

N2 - Tongue squamous cell carcinoma (TSCC) has a poor prognosis due to its early metastasis via blood and lymphatic vessels. We performed a systematic review to investigate the prognostic significance of blood microvessel density (MVD) and lymphatic vessel density (LVD) in TSCC patients. We conducted a systematic search in Ovid Medline, Scopus, and Cochrane libraries. All studies that evaluated the prognostic significance of MVD/LVD markers in TSCC were systematically retrieved. Our results showed that MVD/LVD markers, CD31, CD34, CD105, factor VIII, LYVE‐1, and D2‐40 were evaluated in TSCC patients until 28 June 2018. Six out of 13 studies reported markers that were associated with poor prognosis in TSCC. Two out of three studies suggested that a high number of D2‐40+ vessels predicated low overall survival (OS); the third study reported that the ratio of D2‐40+ over factor VIII+ vessels is associated with low OS. Most of the other markers had controversial results for prognostication. We found higher expression of MVD/LVD markers were commonly, but not always, associated with shorter survival in TSCC patients. It is therefore not currently possible to recommend implementation of these markers as reliable prognosticators in clinical practice. More studies (especially for D2‐40) with larger patient cohorts are needed.

AB - Tongue squamous cell carcinoma (TSCC) has a poor prognosis due to its early metastasis via blood and lymphatic vessels. We performed a systematic review to investigate the prognostic significance of blood microvessel density (MVD) and lymphatic vessel density (LVD) in TSCC patients. We conducted a systematic search in Ovid Medline, Scopus, and Cochrane libraries. All studies that evaluated the prognostic significance of MVD/LVD markers in TSCC were systematically retrieved. Our results showed that MVD/LVD markers, CD31, CD34, CD105, factor VIII, LYVE‐1, and D2‐40 were evaluated in TSCC patients until 28 June 2018. Six out of 13 studies reported markers that were associated with poor prognosis in TSCC. Two out of three studies suggested that a high number of D2‐40+ vessels predicated low overall survival (OS); the third study reported that the ratio of D2‐40+ over factor VIII+ vessels is associated with low OS. Most of the other markers had controversial results for prognostication. We found higher expression of MVD/LVD markers were commonly, but not always, associated with shorter survival in TSCC patients. It is therefore not currently possible to recommend implementation of these markers as reliable prognosticators in clinical practice. More studies (especially for D2‐40) with larger patient cohorts are needed.

KW - ANGIOGENESIS

KW - ASSOCIATION

KW - CD105 EXPRESSION

KW - DENSITY

KW - HEAD

KW - HEPATOCELLULAR-CARCINOMA

KW - LYMPHANGIOGENESIS

KW - NODE METASTASIS

KW - SQUAMOUS-CELL CARCINOMA

KW - VASCULAR INVASION

KW - biomarker

KW - blood microvessel density

KW - lymphatic vessel density

KW - prognosis

KW - tongue squamous cell carcinoma

KW - 3122 Cancers

KW - 111 Mathematics

U2 - 10.1111/cas.14189

DO - 10.1111/cas.14189

M3 - Review Article

VL - 110

JO - Cancer Science

JF - Cancer Science

SN - 1347-9032

IS - 11

ER -