Progress in human picornavirus research

New findings from the AIROPico consortium

Katja C. Wolthers, Petri Susi, Dirk Jochmans, Janne Koskinen, Olfert Landt, Neus Sanchez, Kaia Palm, Johan Neyts, Sarah J. Butcher

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Several research groups in Europe are active on different aspects of human picornavirus research. The AIROPico (Academia-Industry R&D Opportunities for Picornaviruses) consortium combined the disciplines of pathogenesis, diagnostics and therapy development in order to fill the gaps in our understanding of how picornaviruses cause human disease and how to combat them. AIROPico was the first EU consortium dedicated to human picornavirus research and development, and has largely accelerated and improved R&D on picornavirus biology, diagnostics and therapy. In this article, we present the progress on pathogenesis, diagnostics and treatment strategy developments for human picornaviruses resulting from the structured, translational research approach of the AIROPico consortium. We here summarize new insights in protection against infection by maternal or cross-protective antibodies, the visualisation of interactions between virus and neutralizing antibodies by cryoEM structural imaging, and the outcomes from a picornavirus-infected human 3D organoid. Progress in molecular detection and a fast typing assay for rhinovirus species are presented, as well as the identification of new compounds potentially interesting as therapeutic compounds.
Original languageEnglish
JournalAntiviral Research
Volume161
Pages (from-to)100-107
Number of pages8
ISSN0166-3542
DOIs
Publication statusPublished - Jan 2019
MoE publication typeA1 Journal article-refereed

Fields of Science

  • Picomavirus
  • Enterovirus
  • Point of care (POC) diagnostics
  • Pathogenesis
  • Antiviral therapy
  • RESPIRATORY VIRAL-INFECTIONS
  • DISEASE
  • NEUTRALIZATION
  • REPLICATION
  • ASSOCIATION
  • PERFORMANCE
  • INHIBITORS
  • INFLUENZA
  • OUTBREAK
  • VIRUSES
  • 1183 Plant biology, microbiology, virology

Cite this

Wolthers, Katja C. ; Susi, Petri ; Jochmans, Dirk ; Koskinen, Janne ; Landt, Olfert ; Sanchez, Neus ; Palm, Kaia ; Neyts, Johan ; Butcher, Sarah J. / Progress in human picornavirus research : New findings from the AIROPico consortium. In: Antiviral Research. 2019 ; Vol. 161. pp. 100-107.
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abstract = "Several research groups in Europe are active on different aspects of human picornavirus research. The AIROPico (Academia-Industry R&D Opportunities for Picornaviruses) consortium combined the disciplines of pathogenesis, diagnostics and therapy development in order to fill the gaps in our understanding of how picornaviruses cause human disease and how to combat them. AIROPico was the first EU consortium dedicated to human picornavirus research and development, and has largely accelerated and improved R&D on picornavirus biology, diagnostics and therapy. In this article, we present the progress on pathogenesis, diagnostics and treatment strategy developments for human picornaviruses resulting from the structured, translational research approach of the AIROPico consortium. We here summarize new insights in protection against infection by maternal or cross-protective antibodies, the visualisation of interactions between virus and neutralizing antibodies by cryoEM structural imaging, and the outcomes from a picornavirus-infected human 3D organoid. Progress in molecular detection and a fast typing assay for rhinovirus species are presented, as well as the identification of new compounds potentially interesting as therapeutic compounds.",
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author = "Wolthers, {Katja C.} and Petri Susi and Dirk Jochmans and Janne Koskinen and Olfert Landt and Neus Sanchez and Kaia Palm and Johan Neyts and Butcher, {Sarah J.}",
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Wolthers, KC, Susi, P, Jochmans, D, Koskinen, J, Landt, O, Sanchez, N, Palm, K, Neyts, J & Butcher, SJ 2019, 'Progress in human picornavirus research: New findings from the AIROPico consortium', Antiviral Research, vol. 161, pp. 100-107. https://doi.org/10.1016/j.antiviral.2018.11.010

Progress in human picornavirus research : New findings from the AIROPico consortium. / Wolthers, Katja C.; Susi, Petri; Jochmans, Dirk; Koskinen, Janne; Landt, Olfert; Sanchez, Neus; Palm, Kaia; Neyts, Johan; Butcher, Sarah J.

In: Antiviral Research, Vol. 161, 01.2019, p. 100-107.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Progress in human picornavirus research

T2 - New findings from the AIROPico consortium

AU - Wolthers, Katja C.

AU - Susi, Petri

AU - Jochmans, Dirk

AU - Koskinen, Janne

AU - Landt, Olfert

AU - Sanchez, Neus

AU - Palm, Kaia

AU - Neyts, Johan

AU - Butcher, Sarah J.

PY - 2019/1

Y1 - 2019/1

N2 - Several research groups in Europe are active on different aspects of human picornavirus research. The AIROPico (Academia-Industry R&D Opportunities for Picornaviruses) consortium combined the disciplines of pathogenesis, diagnostics and therapy development in order to fill the gaps in our understanding of how picornaviruses cause human disease and how to combat them. AIROPico was the first EU consortium dedicated to human picornavirus research and development, and has largely accelerated and improved R&D on picornavirus biology, diagnostics and therapy. In this article, we present the progress on pathogenesis, diagnostics and treatment strategy developments for human picornaviruses resulting from the structured, translational research approach of the AIROPico consortium. We here summarize new insights in protection against infection by maternal or cross-protective antibodies, the visualisation of interactions between virus and neutralizing antibodies by cryoEM structural imaging, and the outcomes from a picornavirus-infected human 3D organoid. Progress in molecular detection and a fast typing assay for rhinovirus species are presented, as well as the identification of new compounds potentially interesting as therapeutic compounds.

AB - Several research groups in Europe are active on different aspects of human picornavirus research. The AIROPico (Academia-Industry R&D Opportunities for Picornaviruses) consortium combined the disciplines of pathogenesis, diagnostics and therapy development in order to fill the gaps in our understanding of how picornaviruses cause human disease and how to combat them. AIROPico was the first EU consortium dedicated to human picornavirus research and development, and has largely accelerated and improved R&D on picornavirus biology, diagnostics and therapy. In this article, we present the progress on pathogenesis, diagnostics and treatment strategy developments for human picornaviruses resulting from the structured, translational research approach of the AIROPico consortium. We here summarize new insights in protection against infection by maternal or cross-protective antibodies, the visualisation of interactions between virus and neutralizing antibodies by cryoEM structural imaging, and the outcomes from a picornavirus-infected human 3D organoid. Progress in molecular detection and a fast typing assay for rhinovirus species are presented, as well as the identification of new compounds potentially interesting as therapeutic compounds.

KW - Picomavirus

KW - Enterovirus

KW - Point of care (POC) diagnostics

KW - Pathogenesis

KW - Antiviral therapy

KW - RESPIRATORY VIRAL-INFECTIONS

KW - DISEASE

KW - NEUTRALIZATION

KW - REPLICATION

KW - ASSOCIATION

KW - PERFORMANCE

KW - INHIBITORS

KW - INFLUENZA

KW - OUTBREAK

KW - VIRUSES

KW - 1183 Plant biology, microbiology, virology

U2 - 10.1016/j.antiviral.2018.11.010

DO - 10.1016/j.antiviral.2018.11.010

M3 - Article

VL - 161

SP - 100

EP - 107

JO - Antiviral Research

JF - Antiviral Research

SN - 0166-3542

ER -