PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia

Henna Konttinen; Mauricio e Castro Cabral-da-Silva; Sohvi Ohtonen; Sara Wojciechowski; Anastasia Shakirzyanova; Simone Caligola; Rosalba Giugno; Yevheniia Ishchenko; Damián Hernández; Mohammad Feroze Fazaludeen; Shaila Eamen; Mireia Gómez Budia; Ilkka Fagerlund; Flavia Scoyni; Paula Korhonen; Nadine Huber; Annakaisa Haapasalo; Alex W. Hewitt; James Vickers; Grady C. Smith; Minna Oksanen; Caroline Graff; Katja M. Kanninen; Sarka Lehtonen; Nicholas Propson; Michael P. Schwartz; Alice Pébay; Jari Koistinaho; Lezanne Ooi; Tarja Malm

doi:10.1016/j.stemcr.2019.08.004

PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia

Henna Konttinen, Mauricio e Castro Cabral-da-Silva, Sohvi Ohtonen, Sara Wojciechowski, Anastasia Shakirzyanova, Simone Caligola, Rosalba Giugno, Yevheniia Ishchenko, Damián Hernández, Mohammad Feroze Fazaludeen, Shaila Eamen, Mireia Gómez Budia, Ilkka Fagerlund, Flavia Scoyni, Paula Korhonen, Nadine Huber, Annakaisa Haapasalo, Alex W. Hewitt, James Vickers, Grady C. SmithMinna Oksanen, Caroline Graff, Katja M. Kanninen, Sarka Lehtonen, Nicholas Propson, Michael P. Schwartz, Alice Pébay, Jari Koistinaho, Lezanne Ooi, Tarja Malm

Neuroscience Center

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Stem cell reports
Volume	13
Issue number	4
Pages (from-to)	669-683
Number of pages	15
ISSN	2213-6711
DOIs	https://doi.org/10.1016/j.stemcr.2019.08.004
Publication status	Published - 8 Oct 2019
MoE publication type	A1 Journal article-refereed

Fields of Science

Alzheimer disease
iPSC
microglia
phagocytosis
mitochondria
metabolism
PLURIPOTENT STEM-CELLS
ALZHEIMERS-DISEASE
PRECURSOR PROTEIN
BETA
DIFFERENTIATION
MODEL
HEMATOPOIESIS
PRESENILIN-1
MACROPHAGES
ACTIVATION
1182 Biochemistry, cell and molecular biology
3111 Biomedicine

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Cite this

Konttinen, H., Cabral-da-Silva, M. E. C., Ohtonen, S., Wojciechowski, S., Shakirzyanova, A., Caligola, S., Giugno, R., Ishchenko, Y., Hernández, D., Fazaludeen, M. F., Eamen, S., Budia, M. G., Fagerlund, I., Scoyni, F., Korhonen, P., Huber, N., Haapasalo, A., Hewitt, A. W., Vickers, J., ... Malm, T. (2019). PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia. Stem cell reports, 13(4), 669-683. https://doi.org/10.1016/j.stemcr.2019.08.004

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title = "PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia",

keywords = "Alzheimer disease, iPSC, microglia, phagocytosis, mitochondria, metabolism, PLURIPOTENT STEM-CELLS, ALZHEIMERS-DISEASE, PRECURSOR PROTEIN, BETA, DIFFERENTIATION, MODEL, HEMATOPOIESIS, PRESENILIN-1, MACROPHAGES, ACTIVATION, 1182 Biochemistry, cell and molecular biology, 3111 Biomedicine",

author = "Henna Konttinen and Cabral-da-Silva, {Mauricio e Castro} and Sohvi Ohtonen and Sara Wojciechowski and Anastasia Shakirzyanova and Simone Caligola and Rosalba Giugno and Yevheniia Ishchenko and Dami{\'a}n Hern{\'a}ndez and Fazaludeen, {Mohammad Feroze} and Shaila Eamen and Budia, {Mireia G{\'o}mez} and Ilkka Fagerlund and Flavia Scoyni and Paula Korhonen and Nadine Huber and Annakaisa Haapasalo and Hewitt, {Alex W.} and James Vickers and Smith, {Grady C.} and Minna Oksanen and Caroline Graff and Kanninen, {Katja M.} and Sarka Lehtonen and Nicholas Propson and Schwartz, {Michael P.} and Alice P{\'e}bay and Jari Koistinaho and Lezanne Ooi and Tarja Malm",

year = "2019",

month = oct,

day = "8",

doi = "10.1016/j.stemcr.2019.08.004",

language = "English",

volume = "13",

pages = "669--683",

journal = "Stem cell reports",

issn = "2213-6711",

publisher = "Cell Press",

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Konttinen, H, Cabral-da-Silva, MEC, Ohtonen, S, Wojciechowski, S, Shakirzyanova, A, Caligola, S, Giugno, R, Ishchenko, Y, Hernández, D, Fazaludeen, MF, Eamen, S, Budia, MG, Fagerlund, I, Scoyni, F, Korhonen, P, Huber, N, Haapasalo, A, Hewitt, AW, Vickers, J, Smith, GC, Oksanen, M, Graff, C, Kanninen, KM, Lehtonen, S, Propson, N, Schwartz, MP, Pébay, A, Koistinaho, J, Ooi, L & Malm, T 2019, 'PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia', Stem cell reports, vol. 13, no. 4, pp. 669-683. https://doi.org/10.1016/j.stemcr.2019.08.004

TY - JOUR

T1 - PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia

AU - Konttinen, Henna

AU - Cabral-da-Silva, Mauricio e Castro

AU - Ohtonen, Sohvi

AU - Wojciechowski, Sara

AU - Shakirzyanova, Anastasia

AU - Caligola, Simone

AU - Giugno, Rosalba

AU - Ishchenko, Yevheniia

AU - Hernández, Damián

AU - Fazaludeen, Mohammad Feroze

AU - Eamen, Shaila

AU - Budia, Mireia Gómez

AU - Fagerlund, Ilkka

AU - Scoyni, Flavia

AU - Korhonen, Paula

AU - Huber, Nadine

AU - Haapasalo, Annakaisa

AU - Hewitt, Alex W.

AU - Vickers, James

AU - Smith, Grady C.

AU - Oksanen, Minna

AU - Graff, Caroline

AU - Kanninen, Katja M.

AU - Lehtonen, Sarka

AU - Propson, Nicholas

AU - Schwartz, Michael P.

AU - Pébay, Alice

AU - Koistinaho, Jari

AU - Ooi, Lezanne

AU - Malm, Tarja

PY - 2019/10/8

Y1 - 2019/10/8

KW - Alzheimer disease

KW - iPSC

KW - microglia

KW - phagocytosis

KW - mitochondria

KW - metabolism

KW - PLURIPOTENT STEM-CELLS

KW - ALZHEIMERS-DISEASE

KW - PRECURSOR PROTEIN

KW - BETA

KW - DIFFERENTIATION

KW - MODEL

KW - HEMATOPOIESIS

KW - PRESENILIN-1

KW - MACROPHAGES

KW - ACTIVATION

KW - 1182 Biochemistry, cell and molecular biology

KW - 3111 Biomedicine

U2 - 10.1016/j.stemcr.2019.08.004

DO - 10.1016/j.stemcr.2019.08.004

M3 - Article

VL - 13

SP - 669

EP - 683

JO - Stem cell reports

JF - Stem cell reports

SN - 2213-6711

IS - 4

ER -