Psychedelics promote plasticity by directly binding to BDNF receptor TrkB

Rafael Moliner; Mykhailo Girych; Cecilia A. Brunello; Vera Kovaleva; Caroline Biojone; Giray Enkavi; Lina Antenucci; Erik F. Kot; Sergey A. Goncharuk; Katja Kaurinkoski; Mirjami Kuutti; Senem M. Fred; Lauri Elsilä; Sven Sakson; Cecilia Cannarozzo; Cassiano R. A. F. Diniz; Nina Seiffert; Anna Rubiolo; Hele Haapaniemi; Elsa Meshi; Elina Nagaeva; Tiina Öhman; Tomasz Rog; Esko Kankuri; Marçal Vilar; Markku Varjosalo; Esa R. Korpi; Perttu Permi; Konstantin S. Mineev; Mart Saarma; Ilpo Vattulainen; Plinio C. Casarotto; Eero Castren

doi:10.1038/s41593-023-01316-5

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB

Rafael Moliner, Mykhailo Girych, Cecilia A. Brunello, Vera Kovaleva, Caroline Biojone, Giray Enkavi, Lina Antenucci, Erik F. Kot, Sergey A. Goncharuk, Katja Kaurinkoski, Mirjami Kuutti, Senem M. Fred, Lauri Elsilä, Sven Sakson, Cecilia Cannarozzo, Cassiano R. A. F. Diniz, Nina Seiffert, Anna Rubiolo, Hele Haapaniemi, Elsa MeshiElina Nagaeva, Tiina Öhman, Tomasz Rog, Esko Kankuri, Marçal Vilar, Markku Varjosalo, Esa R. Korpi, Perttu Permi, Konstantin S. Mineev, Mart Saarma, Ilpo Vattulainen, Plinio C. Casarotto, Eero Castren

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Nature Neuroscience
Volume	26
Issue number	6
Pages (from-to)	1032–1041
Number of pages	31
ISSN	1097-6256
DOIs	https://doi.org/10.1038/s41593-023-01316-5
Publication status	Published - Jun 2023
MoE publication type	A1 Journal article-refereed

Fields of Science

Neurotrophic factor
Antidepressant drugs
Plasma-membrane
Force-field
Cortical plasticity
Surface expression
Chemical-shift
Growth
Activation
Psilocybin
3112 Neurosciences
3111 Biomedicine
1182 Biochemistry, cell and molecular biology
114 Physical sciences

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s41593-023-01316-5Final published version, 12.9 MBLicence: CC BY

Cite this

Moliner, R., Girych, M., Brunello, C. A., Kovaleva, V., Biojone, C., Enkavi, G., Antenucci, L., Kot, E. F., Goncharuk, S. A., Kaurinkoski, K., Kuutti, M., Fred, S. M., Elsilä, L., Sakson, S., Cannarozzo, C., Diniz, C. R. A. F., Seiffert, N., Rubiolo, A., Haapaniemi, H., ... Castren, E. (2023). Psychedelics promote plasticity by directly binding to BDNF receptor TrkB. Nature Neuroscience, 26(6), 1032–1041. https://doi.org/10.1038/s41593-023-01316-5

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title = "Psychedelics promote plasticity by directly binding to BDNF receptor TrkB",

keywords = "Neurotrophic factor, Antidepressant drugs, Plasma-membrane, Force-field, Cortical plasticity, Surface expression, Chemical-shift, Growth, Activation, Psilocybin, 3112 Neurosciences, 3111 Biomedicine, 1182 Biochemistry, cell and molecular biology, 114 Physical sciences",

author = "Rafael Moliner and Mykhailo Girych and Brunello, {Cecilia A.} and Vera Kovaleva and Caroline Biojone and Giray Enkavi and Lina Antenucci and Kot, {Erik F.} and Goncharuk, {Sergey A.} and Katja Kaurinkoski and Mirjami Kuutti and Fred, {Senem M.} and Lauri Elsil{\"a} and Sven Sakson and Cecilia Cannarozzo and Diniz, {Cassiano R. A. F.} and Nina Seiffert and Anna Rubiolo and Hele Haapaniemi and Elsa Meshi and Elina Nagaeva and Tiina {\"O}hman and Tomasz Rog and Esko Kankuri and Mar{\c c}al Vilar and Markku Varjosalo and Korpi, {Esa R.} and Perttu Permi and Mineev, {Konstantin S.} and Mart Saarma and Ilpo Vattulainen and Casarotto, {Plinio C.} and Eero Castren",

year = "2023",

month = jun,

doi = "10.1038/s41593-023-01316-5",

language = "English",

volume = "26",

pages = "1032–1041",

journal = "Nature Neuroscience",

issn = "1097-6256",

publisher = "Nature publishing group",

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Moliner, R , Girych, M , Brunello, CA , Kovaleva, V, Biojone, C, Enkavi, G, Antenucci, L, Kot, EF, Goncharuk, SA, Kaurinkoski, K, Kuutti, M, Fred, SM , Elsilä, L , Sakson, S , Cannarozzo, C, Diniz, CRAF, Seiffert, N, Rubiolo, A, Haapaniemi, H, Meshi, E, Nagaeva, E, Öhman, T, Rog, T, Kankuri, E, Vilar, M, Varjosalo, M , Korpi, ER , Permi, P, Mineev, KS, Saarma, M , Vattulainen, I, Casarotto, PC & Castren, E 2023, 'Psychedelics promote plasticity by directly binding to BDNF receptor TrkB', Nature Neuroscience, vol. 26, no. 6, pp. 1032–1041. https://doi.org/10.1038/s41593-023-01316-5

TY - JOUR

T1 - Psychedelics promote plasticity by directly binding to BDNF receptor TrkB

AU - Moliner, Rafael

AU - Girych, Mykhailo

AU - Brunello, Cecilia A.

AU - Kovaleva, Vera

AU - Biojone, Caroline

AU - Enkavi, Giray

AU - Antenucci, Lina

AU - Kot, Erik F.

AU - Goncharuk, Sergey A.

AU - Kaurinkoski, Katja

AU - Kuutti, Mirjami

AU - Fred, Senem M.

AU - Elsilä, Lauri

AU - Sakson, Sven

AU - Cannarozzo, Cecilia

AU - Diniz, Cassiano R. A. F.

AU - Seiffert, Nina

AU - Rubiolo, Anna

AU - Haapaniemi, Hele

AU - Meshi, Elsa

AU - Nagaeva, Elina

AU - Öhman, Tiina

AU - Rog, Tomasz

AU - Kankuri, Esko

AU - Vilar, Marçal

AU - Varjosalo, Markku

AU - Korpi, Esa R.

AU - Permi, Perttu

AU - Mineev, Konstantin S.

AU - Saarma, Mart

AU - Vattulainen, Ilpo

AU - Casarotto, Plinio C.

AU - Castren, Eero

PY - 2023/6

Y1 - 2023/6

KW - Neurotrophic factor

KW - Antidepressant drugs

KW - Plasma-membrane

KW - Force-field

KW - Cortical plasticity

KW - Surface expression

KW - Chemical-shift

KW - Growth

KW - Activation

KW - Psilocybin

KW - 3112 Neurosciences

KW - 3111 Biomedicine

KW - 1182 Biochemistry, cell and molecular biology

KW - 114 Physical sciences

U2 - 10.1038/s41593-023-01316-5

DO - 10.1038/s41593-023-01316-5

M3 - Article

C2 - 37280397

SN - 1097-6256

VL - 26

SP - 1032

EP - 1041

JO - Nature Neuroscience

JF - Nature Neuroscience

IS - 6

ER -