Recent progress and challenges in screening and characterization of UGT1A1 inhibitors

Xia Lv, Yangliu Xia, Moshe Finel, Jingjing Wu, Guangbo Ge, Ling Yang

Research output: Contribution to journalReview ArticleScientificpeer-review

Original languageEnglish
JournalActa pharmaceutica sinica b
Volume9
Issue number2
Pages (from-to)258-278
Number of pages21
ISSN2211-3835
DOIs
Publication statusPublished - Mar 2019
MoE publication typeA2 Review article in a scientific journal

Fields of Science

  • UGT1A1 inhibitors
  • Drug/herbdrug interactions
  • Probe substrates
  • High-throughput screening
  • UDP-GLUCURONOSYLTRANSFERASE 1A1
  • HUMAN LIVER-MICROSOMES
  • RATIOMETRIC FLUORESCENT-PROBE
  • PRIMARY HUMAN HEPATOCYTES
  • HUMAN CARBOXYLESTERASE 2
  • IN-VITRO INHIBITION
  • BILIRUBIN GLUCURONIDATION
  • GENETIC-POLYMORPHISM
  • DRUG-INTERACTIONS
  • ENZYME-ACTIVITIES
  • 116 Chemical sciences
  • 317 Pharmacy

Cite this

Lv, Xia ; Xia, Yangliu ; Finel, Moshe ; Wu, Jingjing ; Ge, Guangbo ; Yang, Ling. / Recent progress and challenges in screening and characterization of UGT1A1 inhibitors. In: Acta pharmaceutica sinica b. 2019 ; Vol. 9, No. 2. pp. 258-278.
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title = "Recent progress and challenges in screening and characterization of UGT1A1 inhibitors",
keywords = "UGT1A1 inhibitors, Drug/herbdrug interactions, Probe substrates, High-throughput screening, UDP-GLUCURONOSYLTRANSFERASE 1A1, HUMAN LIVER-MICROSOMES, RATIOMETRIC FLUORESCENT-PROBE, PRIMARY HUMAN HEPATOCYTES, HUMAN CARBOXYLESTERASE 2, IN-VITRO INHIBITION, BILIRUBIN GLUCURONIDATION, GENETIC-POLYMORPHISM, DRUG-INTERACTIONS, ENZYME-ACTIVITIES, 116 Chemical sciences, 317 Pharmacy",
author = "Xia Lv and Yangliu Xia and Moshe Finel and Jingjing Wu and Guangbo Ge and Ling Yang",
year = "2019",
month = "3",
doi = "10.1016/j.apsb.2018.09.005",
language = "English",
volume = "9",
pages = "258--278",
journal = "Acta pharmaceutica sinica b",
issn = "2211-3835",
publisher = "Elsevier",
number = "2",

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Recent progress and challenges in screening and characterization of UGT1A1 inhibitors. / Lv, Xia; Xia, Yangliu; Finel, Moshe; Wu, Jingjing; Ge, Guangbo; Yang, Ling.

In: Acta pharmaceutica sinica b, Vol. 9, No. 2, 03.2019, p. 258-278.

Research output: Contribution to journalReview ArticleScientificpeer-review

TY - JOUR

T1 - Recent progress and challenges in screening and characterization of UGT1A1 inhibitors

AU - Lv, Xia

AU - Xia, Yangliu

AU - Finel, Moshe

AU - Wu, Jingjing

AU - Ge, Guangbo

AU - Yang, Ling

PY - 2019/3

Y1 - 2019/3

KW - UGT1A1 inhibitors

KW - Drug/herbdrug interactions

KW - Probe substrates

KW - High-throughput screening

KW - UDP-GLUCURONOSYLTRANSFERASE 1A1

KW - HUMAN LIVER-MICROSOMES

KW - RATIOMETRIC FLUORESCENT-PROBE

KW - PRIMARY HUMAN HEPATOCYTES

KW - HUMAN CARBOXYLESTERASE 2

KW - IN-VITRO INHIBITION

KW - BILIRUBIN GLUCURONIDATION

KW - GENETIC-POLYMORPHISM

KW - DRUG-INTERACTIONS

KW - ENZYME-ACTIVITIES

KW - 116 Chemical sciences

KW - 317 Pharmacy

U2 - 10.1016/j.apsb.2018.09.005

DO - 10.1016/j.apsb.2018.09.005

M3 - Review Article

VL - 9

SP - 258

EP - 278

JO - Acta pharmaceutica sinica b

JF - Acta pharmaceutica sinica b

SN - 2211-3835

IS - 2

ER -