Recent progress and challenges in screening and characterization of UGT1A1 inhibitors

Xia Lv, Yangliu Xia, Moshe Finel, Jingjing Wu, Guangbo Ge, Ling Yang

Research output: Contribution to journalReview ArticleScientificpeer-review

Original languageEnglish
JournalActa pharmaceutica sinica b
Volume9
Issue number2
Pages (from-to)258-278
Number of pages21
ISSN2211-3835
DOIs
Publication statusPublished - Mar 2019
MoE publication typeA2 Review article in a scientific journal

Fields of Science

  • UGT1A1 inhibitors
  • Drug/herbdrug interactions
  • Probe substrates
  • High-throughput screening
  • UDP-GLUCURONOSYLTRANSFERASE 1A1
  • HUMAN LIVER-MICROSOMES
  • RATIOMETRIC FLUORESCENT-PROBE
  • PRIMARY HUMAN HEPATOCYTES
  • HUMAN CARBOXYLESTERASE 2
  • IN-VITRO INHIBITION
  • BILIRUBIN GLUCURONIDATION
  • GENETIC-POLYMORPHISM
  • DRUG-INTERACTIONS
  • ENZYME-ACTIVITIES
  • 116 Chemical sciences
  • 317 Pharmacy

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