Reduced binding of apoE4 to complement factor H promotes amyloid-beta oligomerization and neuroinflammation

Larisa Chernyaeva; Giorgio Ratti; Laura Teirilä; Satoshi Fudo; Uni Rankka; Anssi Pelkonen; Paula Korhonen; Katarzyna Leskinen; Salla Keskitalo; Kari Salokas; Christina Gkolfinopoulou; Katrina E. Crompton; Matti Javanainen; Lotta Happonen; Markku Varjosalo; Tarja Malm; Ville Leinonen; Angeliki Chroni; Päivi Saavalainen; Seppo Meri; Tommi Kajander; Adam J. M. Wollman; Eija Nissilä; Karita Haapasalo

doi:10.15252/embr.202256467

Reduced binding of apoE4 to complement factor H promotes amyloid-beta oligomerization and neuroinflammation

Larisa Chernyaeva
, Giorgio Ratti
, Laura Teirilä
, Satoshi Fudo
, Uni Rankka
, Anssi Pelkonen
, Paula Korhonen
, Katarzyna Leskinen
, Salla Keskitalo
, Kari Salokas
, Christina Gkolfinopoulou
, Katrina E. Crompton
, Matti Javanainen
, Lotta Happonen
, Markku Varjosalo
, Tarja Malm
, Ville Leinonen
, Angeliki Chroni
, Päivi Saavalainen
, Seppo Meri

Tommi Kajander, Adam J. M. Wollman, Eija Nissilä, Karita Haapasalo

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Article number	e56467
Journal	EMBO Reports
Volume	24
Issue number	7
Number of pages	23
ISSN	1469-221X
DOIs	https://doi.org/10.15252/embr.202256467
Publication status	Published - 5 Jul 2023
MoE publication type	A1 Journal article-refereed

Fields of Science

apoE
Dementia
factor H
Inflammation
Neurodegeneration
1182 Biochemistry, cell and molecular biology
3112 Neurosciences

Access to Document

10.15252/embr.202256467Licence: CC BY

EMBO Reports - 2023 - Chernyaeva - Reduced binding of apoE4 to complement factor H promotes amyloid‐ oligomerization andFinal published version, 11.9 MBLicence: CC BY

Cite this

Chernyaeva, L., Ratti, G., Teirilä, L., Fudo, S., Rankka, U., Pelkonen, A., Korhonen, P., Leskinen, K., Keskitalo, S., Salokas, K., Gkolfinopoulou, C., Crompton, K. E., Javanainen, M., Happonen, L., Varjosalo, M., Malm, T., Leinonen, V., Chroni, A., Saavalainen, P., ... Haapasalo, K. (2023). Reduced binding of apoE4 to complement factor H promotes amyloid-beta oligomerization and neuroinflammation. EMBO Reports, 24(7), Article e56467. https://doi.org/10.15252/embr.202256467

@article{3b6d3a85741047e49869c421708f6499,

title = "Reduced binding of apoE4 to complement factor H promotes amyloid-beta oligomerization and neuroinflammation",

keywords = "apoE, Dementia, factor H, Inflammation, Neurodegeneration, 1182 Biochemistry, cell and molecular biology, 3112 Neurosciences",

author = "Larisa Chernyaeva and Giorgio Ratti and Laura Teiril{\"a} and Satoshi Fudo and Uni Rankka and Anssi Pelkonen and Paula Korhonen and Katarzyna Leskinen and Salla Keskitalo and Kari Salokas and Christina Gkolfinopoulou and Crompton, \{Katrina E.\} and Matti Javanainen and Lotta Happonen and Markku Varjosalo and Tarja Malm and Ville Leinonen and Angeliki Chroni and P{\"a}ivi Saavalainen and Seppo Meri and Tommi Kajander and Wollman, \{Adam J. M.\} and Eija Nissil{\"a} and Karita Haapasalo",

year = "2023",

month = jul,

day = "5",

doi = "10.15252/embr.202256467",

language = "English",

volume = "24",

journal = "EMBO Reports",

issn = "1469-221X",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "7",

}

Chernyaeva, L, Ratti, G, Teirilä, L, Fudo, S, Rankka, U, Pelkonen, A, Korhonen, P, Leskinen, K, Keskitalo, S , Salokas, K, Gkolfinopoulou, C, Crompton, KE, Javanainen, M, Happonen, L, Varjosalo, M, Malm, T, Leinonen, V, Chroni, A, Saavalainen, P , Meri, S , Kajander, T, Wollman, AJM, Nissilä, E & Haapasalo, K 2023, 'Reduced binding of apoE4 to complement factor H promotes amyloid-beta oligomerization and neuroinflammation', EMBO Reports, vol. 24, no. 7, e56467. https://doi.org/10.15252/embr.202256467

TY - JOUR

T1 - Reduced binding of apoE4 to complement factor H promotes amyloid-beta oligomerization and neuroinflammation

AU - Chernyaeva, Larisa

AU - Ratti, Giorgio

AU - Teirilä, Laura

AU - Fudo, Satoshi

AU - Rankka, Uni

AU - Pelkonen, Anssi

AU - Korhonen, Paula

AU - Leskinen, Katarzyna

AU - Keskitalo, Salla

AU - Salokas, Kari

AU - Gkolfinopoulou, Christina

AU - Crompton, Katrina E.

AU - Javanainen, Matti

AU - Happonen, Lotta

AU - Varjosalo, Markku

AU - Malm, Tarja

AU - Leinonen, Ville

AU - Chroni, Angeliki

AU - Saavalainen, Päivi

AU - Meri, Seppo

AU - Kajander, Tommi

AU - Wollman, Adam J. M.

AU - Nissilä, Eija

AU - Haapasalo, Karita

PY - 2023/7/5

Y1 - 2023/7/5

KW - apoE

KW - Dementia

KW - factor H

KW - Inflammation

KW - Neurodegeneration

KW - 1182 Biochemistry, cell and molecular biology

KW - 3112 Neurosciences

U2 - 10.15252/embr.202256467

DO - 10.15252/embr.202256467

M3 - Article

C2 - 37155564

SN - 1469-221X

VL - 24

JO - EMBO Reports

JF - EMBO Reports

IS - 7

M1 - e56467

ER -