Regulation of mammalian tooth cusp patterning by ectodin

Yoshiaki Kassai, Pauliina Munne, Yuhei Hotta, Enni Penttilä, Kathryn Kavanagh, Norihiko Ohbayashi, Shinji Takada, Irma Thesleff, Jukka Jernvall, Nobuyuki Itoh

    Research output: Contribution to journalArticleScientificpeer-review

    Abstract

    "Mammalian tooth crowns have precise functional requirements but cannot be substantially remodeled after eruption. In developing teeth, epithelial, signaling centers, the enamel knots, form at future cusp positions and are the first signs of cusp patterns that distinguish species. We report that ectodin, a secreted bone morphogenetic protein (BMP) inhibitor, is expressed as a ""negative'! image of mouse enamel knots. Furthermore, we show that ectodin-deficient mice have enlarged enamel knots, highly altered cusp patterns, and extra teeth. Unlike in normal teeth, excess BMP accelerates patterning in ectodin-deficient teeth. We propose that ectodin is critical for robust spatial delineation of enamel knots and cusps."
    Original languageEnglish
    JournalScience
    Volume309
    Pages (from-to)2067-2070
    Number of pages4
    ISSN0036-8075
    DOIs
    Publication statusPublished - 2005
    MoE publication typeA1 Journal article-refereed

    Cite this