Repetitive amiodarone administration causes liver damage via adipose tissue ER stress-dependent lipolysis, leading to hepatotoxic free fatty acid accumulation

Einav Hubel; Sigal Fishman; Minna Holopainen; Reijo Käkelä; Ortal Shaffer; Inbal Houri; Isabel Zvibel; Oren Shibolet

doi:10.1152/ajpgi.00458.2020

Repetitive amiodarone administration causes liver damage via adipose tissue ER stress-dependent lipolysis, leading to hepatotoxic free fatty acid accumulation

Einav Hubel, Sigal Fishman, Minna Holopainen, Reijo Käkelä, Ortal Shaffer, Inbal Houri, Isabel Zvibel, Oren Shibolet

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	American Journal of Physiology: Gastrointestinal and Liver Physiology
Volume	321
Pages (from-to)	G298-G307
Number of pages	10
ISSN	0193-1857
DOIs	https://doi.org/10.1152/ajpgi.00458.2020
Publication status	Published - Sep 2021
MoE publication type	A1 Journal article-refereed

Fields of Science

amiodarone
drug-induced liver injury
ER stress
lipogenesis
lipolysis
ENDOPLASMIC-RETICULUM STRESS
PROTEIN
SUPPRESSION
INHIBITION
METABOLISM
ACTIVATION
STEATOSIS
1182 Biochemistry, cell and molecular biology
1184 Genetics, developmental biology, physiology

Access to Document

10.1152/ajpgi.00458.2020

Art 68 20 07 21Accepted author manuscript, 630 KBLicence: Unspecified

Cite this

Hubel, E., Fishman, S., Holopainen, M., Käkelä, R., Shaffer, O., Houri, I., Zvibel, I., & Shibolet, O. (2021). Repetitive amiodarone administration causes liver damage via adipose tissue ER stress-dependent lipolysis, leading to hepatotoxic free fatty acid accumulation. American Journal of Physiology: Gastrointestinal and Liver Physiology, 321, G298-G307. https://doi.org/10.1152/ajpgi.00458.2020

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title = "Repetitive amiodarone administration causes liver damage via adipose tissue ER stress-dependent lipolysis, leading to hepatotoxic free fatty acid accumulation",

keywords = "amiodarone, drug-induced liver injury, ER stress, lipogenesis, lipolysis, ENDOPLASMIC-RETICULUM STRESS, PROTEIN, SUPPRESSION, INHIBITION, METABOLISM, ACTIVATION, STEATOSIS, 1182 Biochemistry, cell and molecular biology, 1184 Genetics, developmental biology, physiology",

author = "Einav Hubel and Sigal Fishman and Minna Holopainen and Reijo K{\"a}kel{\"a} and Ortal Shaffer and Inbal Houri and Isabel Zvibel and Oren Shibolet",

year = "2021",

month = sep,

doi = "10.1152/ajpgi.00458.2020",

language = "English",

volume = "321",

pages = "G298--G307",

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Hubel, E, Fishman, S, Holopainen, M , Käkelä, R, Shaffer, O, Houri, I, Zvibel, I & Shibolet, O 2021, 'Repetitive amiodarone administration causes liver damage via adipose tissue ER stress-dependent lipolysis, leading to hepatotoxic free fatty acid accumulation', American Journal of Physiology: Gastrointestinal and Liver Physiology, vol. 321, pp. G298-G307. https://doi.org/10.1152/ajpgi.00458.2020

Repetitive amiodarone administration causes liver damage via adipose tissue ER stress-dependent lipolysis, leading to hepatotoxic free fatty acid accumulation. / Hubel, Einav; Fishman, Sigal; Holopainen, Minna et al.

In: American Journal of Physiology: Gastrointestinal and Liver Physiology, Vol. 321, 09.2021, p. G298-G307.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Repetitive amiodarone administration causes liver damage via adipose tissue ER stress-dependent lipolysis, leading to hepatotoxic free fatty acid accumulation

AU - Hubel, Einav

AU - Fishman, Sigal

AU - Holopainen, Minna

AU - Käkelä, Reijo

AU - Shaffer, Ortal

AU - Houri, Inbal

AU - Zvibel, Isabel

AU - Shibolet, Oren

PY - 2021/9

Y1 - 2021/9

KW - amiodarone

KW - drug-induced liver injury

KW - ER stress

KW - lipogenesis

KW - lipolysis

KW - ENDOPLASMIC-RETICULUM STRESS

KW - PROTEIN

KW - SUPPRESSION

KW - INHIBITION

KW - METABOLISM

KW - ACTIVATION

KW - STEATOSIS

KW - 1182 Biochemistry, cell and molecular biology

KW - 1184 Genetics, developmental biology, physiology

U2 - 10.1152/ajpgi.00458.2020

DO - 10.1152/ajpgi.00458.2020

M3 - Article

VL - 321

SP - G298-G307

JO - American Journal of Physiology: Gastrointestinal and Liver Physiology

JF - American Journal of Physiology: Gastrointestinal and Liver Physiology

SN - 0193-1857

ER -