Repetitive amiodarone administration causes liver damage via adipose tissue ER stress-dependent lipolysis, leading to hepatotoxic free fatty acid accumulation

Einav Hubel, Sigal Fishman, Minna Holopainen, Reijo Käkelä, Ortal Shaffer, Inbal Houri, Isabel Zvibel, Oren Shibolet

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalAmerican Journal of Physiology: Gastrointestinal and Liver Physiology
Volume321
Pages (from-to)G298-G307
Number of pages10
ISSN0193-1857
DOIs
Publication statusPublished - Sept 2021
MoE publication typeA1 Journal article-refereed

Fields of Science

  • amiodarone
  • drug-induced liver injury
  • ER stress
  • lipogenesis
  • lipolysis
  • ENDOPLASMIC-RETICULUM STRESS
  • PROTEIN
  • SUPPRESSION
  • INHIBITION
  • METABOLISM
  • ACTIVATION
  • STEATOSIS
  • 1182 Biochemistry, cell and molecular biology
  • 1184 Genetics, developmental biology, physiology

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