RhoG deficiency abrogates cytotoxicity of human lymphocytes and causes hemophagocytic lymphohistiocytosis

A Kalinichenko; GP Casoni; L Dupre; L Trotta; J Huemer; D Galgano; Y German; B Haladik; J Pazmandi; M Thian; OY Petronczki; SC Chiang; M Taskinen; A Hekkala; S Kauppila; O Lindgren; T Tapiainen; MJ Kraakman; K Vettenranta; AJ Lomakin; J Saarela; MRJ Seppanen; YT Bryceson; K Boztug

doi:10.1182/blood.2020008738

RhoG deficiency abrogates cytotoxicity of human lymphocytes and causes hemophagocytic lymphohistiocytosis

A Kalinichenko, GP Casoni, L Dupre, L Trotta, J Huemer, D Galgano, Y German, B Haladik, J Pazmandi, M Thian, OY Petronczki, SC Chiang, M Taskinen, A Hekkala, S Kauppila, O Lindgren, T Tapiainen, MJ Kraakman, K Vettenranta, AJ LomakinJ Saarela, MRJ Seppanen, YT Bryceson, K Boztug

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Blood
Volume	137
Issue number	15
Pages (from-to)	2033-2045
Number of pages	13
ISSN	0006-4971
DOIs	https://doi.org/10.1182/blood.2020008738
Publication status	Published - 15 Apr 2021
MoE publication type	A1 Journal article-refereed

Fields of Science

3121 General medicine, internal medicine and other clinical medicine
3123 Gynaecology and paediatrics
ACTIN CYTOSKELETON
EXOCYTOSIS
IDENTIFICATION
MUTATIONS
IMMUNOPATHOLOGY
CONTRIBUTES
ACTIVATION
BINDING
SYNAPSE
FUSION

Access to Document

10.1182/blood.2020008738

RhoG deficiency abrogates cytotoxicity of human lymphocytes and causes hemophagocytic lymphohistiocytosisFinal published version, 2.41 MBLicence: CC BY

Cite this

Kalinichenko, A., Casoni, GP., Dupre, L., Trotta, L., Huemer, J., Galgano, D., German, Y., Haladik, B., Pazmandi, J., Thian, M., Petronczki, OY., Chiang, SC., Taskinen, M., Hekkala, A., Kauppila, S., Lindgren, O., Tapiainen, T., Kraakman, MJ., Vettenranta, K., ... Boztug, K. (2021). RhoG deficiency abrogates cytotoxicity of human lymphocytes and causes hemophagocytic lymphohistiocytosis. Blood, 137(15), 2033-2045. https://doi.org/10.1182/blood.2020008738

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title = "RhoG deficiency abrogates cytotoxicity of human lymphocytes and causes hemophagocytic lymphohistiocytosis",

keywords = "3121 General medicine, internal medicine and other clinical medicine, 3123 Gynaecology and paediatrics, ACTIN CYTOSKELETON, EXOCYTOSIS, IDENTIFICATION, MUTATIONS, IMMUNOPATHOLOGY, CONTRIBUTES, ACTIVATION, BINDING, SYNAPSE, FUSION",

author = "A Kalinichenko and GP Casoni and L Dupre and L Trotta and J Huemer and D Galgano and Y German and B Haladik and J Pazmandi and M Thian and OY Petronczki and SC Chiang and M Taskinen and A Hekkala and S Kauppila and O Lindgren and T Tapiainen and MJ Kraakman and K Vettenranta and AJ Lomakin and J Saarela and MRJ Seppanen and YT Bryceson and K Boztug",

year = "2021",

month = apr,

day = "15",

doi = "10.1182/blood.2020008738",

language = "English",

volume = "137",

pages = "2033--2045",

journal = "Blood",

issn = "0006-4971",

publisher = "American Society of Hematology",

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Kalinichenko, A, Casoni, GP, Dupre, L, Trotta, L, Huemer, J, Galgano, D, German, Y, Haladik, B, Pazmandi, J, Thian, M, Petronczki, OY, Chiang, SC, Taskinen, M, Hekkala, A, Kauppila, S, Lindgren, O, Tapiainen, T, Kraakman, MJ, Vettenranta, K, Lomakin, AJ, Saarela, J , Seppanen, MRJ, Bryceson, YT & Boztug, K 2021, 'RhoG deficiency abrogates cytotoxicity of human lymphocytes and causes hemophagocytic lymphohistiocytosis', Blood, vol. 137, no. 15, pp. 2033-2045. https://doi.org/10.1182/blood.2020008738

TY - JOUR

T1 - RhoG deficiency abrogates cytotoxicity of human lymphocytes and causes hemophagocytic lymphohistiocytosis

AU - Kalinichenko, A

AU - Casoni, GP

AU - Dupre, L

AU - Trotta, L

AU - Huemer, J

AU - Galgano, D

AU - German, Y

AU - Haladik, B

AU - Pazmandi, J

AU - Thian, M

AU - Petronczki, OY

AU - Chiang, SC

AU - Taskinen, M

AU - Hekkala, A

AU - Kauppila, S

AU - Lindgren, O

AU - Tapiainen, T

AU - Kraakman, MJ

AU - Vettenranta, K

AU - Lomakin, AJ

AU - Saarela, J

AU - Seppanen, MRJ

AU - Bryceson, YT

AU - Boztug, K

PY - 2021/4/15

Y1 - 2021/4/15

KW - 3121 General medicine, internal medicine and other clinical medicine

KW - 3123 Gynaecology and paediatrics

KW - ACTIN CYTOSKELETON

KW - EXOCYTOSIS

KW - IDENTIFICATION

KW - MUTATIONS

KW - IMMUNOPATHOLOGY

KW - CONTRIBUTES

KW - ACTIVATION

KW - BINDING

KW - SYNAPSE

KW - FUSION

U2 - 10.1182/blood.2020008738

DO - 10.1182/blood.2020008738

M3 - Article

SN - 0006-4971

VL - 137

SP - 2033

EP - 2045

JO - Blood

JF - Blood

IS - 15

ER -