Role of the microRNA-29 family in fibrotic skin diseases

Duygu Harmanci, Erdogan Pekcan Erkan, Ayse Kocak, Gul Akdogan

Research output: Contribution to journalReview ArticleScientificpeer-review

Abstract

Fibrotic skin diseases are characterized by the accumulation of collagen. The hallmarks of fibrotic skin diseases are unbalanced fibroblast proliferation and differentiation, extracellular matrix production and transforming growth factor‑β signalling. Numerous studies have investigated the possibility that microRNAs (miRNAs or miRs) are involved in the pathogenesis of certain fibrotic diseases, including skin, heart, lung and liver diseases. miRNAs are a class of small non‑coding RNAs, which modify gene expression by binding to target messenger RNA (mRNA) and blocking the translation or inducing the degradation of target mRNA. The biological relevance of miRNAs has been investigated in physiological and pathological conditions, and there is increasing evidence that the miR‑29 family is associated with fibrotic diseases. The aim of the present review is to provide an up‑to‑date summary of current knowledge on the latest developments associated with the miR‑29 family and fibrotic skin diseases.
Original languageEnglish
JournalBiomedical Reports
Volume6
Issue number6
Pages (from-to)599-604
ISSN2049-9434
DOIs
Publication statusPublished - Jun 2017
MoE publication typeA2 Review article in a scientific journal

Fields of Science

  • 3111 Biomedicine

Cite this

Harmanci, Duygu ; Erkan, Erdogan Pekcan ; Kocak, Ayse ; Akdogan, Gul. / Role of the microRNA-29 family in fibrotic skin diseases. In: Biomedical Reports. 2017 ; Vol. 6, No. 6. pp. 599-604.
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Role of the microRNA-29 family in fibrotic skin diseases. / Harmanci, Duygu; Erkan, Erdogan Pekcan; Kocak, Ayse; Akdogan, Gul.

In: Biomedical Reports, Vol. 6, No. 6, 06.2017, p. 599-604.

Research output: Contribution to journalReview ArticleScientificpeer-review

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AU - Erkan, Erdogan Pekcan

AU - Kocak, Ayse

AU - Akdogan, Gul

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N2 - Fibrotic skin diseases are characterized by the accumulation of collagen. The hallmarks of fibrotic skin diseases are unbalanced fibroblast proliferation and differentiation, extracellular matrix production and transforming growth factor‑β signalling. Numerous studies have investigated the possibility that microRNAs (miRNAs or miRs) are involved in the pathogenesis of certain fibrotic diseases, including skin, heart, lung and liver diseases. miRNAs are a class of small non‑coding RNAs, which modify gene expression by binding to target messenger RNA (mRNA) and blocking the translation or inducing the degradation of target mRNA. The biological relevance of miRNAs has been investigated in physiological and pathological conditions, and there is increasing evidence that the miR‑29 family is associated with fibrotic diseases. The aim of the present review is to provide an up‑to‑date summary of current knowledge on the latest developments associated with the miR‑29 family and fibrotic skin diseases.

AB - Fibrotic skin diseases are characterized by the accumulation of collagen. The hallmarks of fibrotic skin diseases are unbalanced fibroblast proliferation and differentiation, extracellular matrix production and transforming growth factor‑β signalling. Numerous studies have investigated the possibility that microRNAs (miRNAs or miRs) are involved in the pathogenesis of certain fibrotic diseases, including skin, heart, lung and liver diseases. miRNAs are a class of small non‑coding RNAs, which modify gene expression by binding to target messenger RNA (mRNA) and blocking the translation or inducing the degradation of target mRNA. The biological relevance of miRNAs has been investigated in physiological and pathological conditions, and there is increasing evidence that the miR‑29 family is associated with fibrotic diseases. The aim of the present review is to provide an up‑to‑date summary of current knowledge on the latest developments associated with the miR‑29 family and fibrotic skin diseases.

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