S-ketamine in patient-controlled analgesia reduces opioid consumption in a dose-dependent manner after major lumbar fusion surgery: A randomized, double-blind, placebo-controlled clinical trial

Elina C. V. Brinck; Taru Virtanen; Sanna Mäkelä; Venla Soini; Ville-Veikko Hynninen; Jukka Mulo; Urmas Savolainen; Juho Rantakokko; Kreu Maisniemi; Antti Liukas; Klaus T. Olkkola; Vesa Kontinen; Pekka Tarkkila; Marko Peltoniemi; Teijo I. Saari

doi:10.1371/journal.pone.0252626

S-ketamine in patient-controlled analgesia reduces opioid consumption in a dose-dependent manner after major lumbar fusion surgery: A randomized, double-blind, placebo-controlled clinical trial

Elina C. V. Brinck, Taru Virtanen, Sanna Mäkelä, Venla Soini, Ville-Veikko Hynninen, Jukka Mulo, Urmas Savolainen, Juho Rantakokko, Kreu Maisniemi, Antti Liukas, Klaus T. Olkkola, Vesa Kontinen, Pekka Tarkkila, Marko Peltoniemi, Teijo I. Saari

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Article number	0252626
Journal	PLoS One
Volume	16
Issue number	6
Number of pages	16
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0252626
Publication status	Published - 7 Jun 2021
MoE publication type	A1 Journal article-refereed

Fields of Science

ACUTE POSTOPERATIVE PAIN
ADDING KETAMINE
MORPHINE
PHARMACODYNAMICS
PHARMACOKINETICS
COMBINATION
RISK
AGE
3126 Surgery, anesthesiology, intensive care, radiology

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journal.pone.0252626Final published version, 1.45 MBLicence: CC BY

Cite this

Brinck, E. C. V., Virtanen, T., Mäkelä, S., Soini, V., Hynninen, V.-V., Mulo, J., Savolainen, U., Rantakokko, J., Maisniemi, K., Liukas, A., Olkkola, K. T., Kontinen, V., Tarkkila, P., Peltoniemi, M., & Saari, T. I. (2021). S-ketamine in patient-controlled analgesia reduces opioid consumption in a dose-dependent manner after major lumbar fusion surgery: A randomized, double-blind, placebo-controlled clinical trial. PLoS One, 16(6), Article 0252626. https://doi.org/10.1371/journal.pone.0252626

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title = "S-ketamine in patient-controlled analgesia reduces opioid consumption in a dose-dependent manner after major lumbar fusion surgery: A randomized, double-blind, placebo-controlled clinical trial",

keywords = "ACUTE POSTOPERATIVE PAIN, ADDING KETAMINE, MORPHINE, PHARMACODYNAMICS, PHARMACOKINETICS, COMBINATION, RISK, AGE, 3126 Surgery, anesthesiology, intensive care, radiology",

author = "Brinck, {Elina C. V.} and Taru Virtanen and Sanna M{\"a}kel{\"a} and Venla Soini and Ville-Veikko Hynninen and Jukka Mulo and Urmas Savolainen and Juho Rantakokko and Kreu Maisniemi and Antti Liukas and Olkkola, {Klaus T.} and Vesa Kontinen and Pekka Tarkkila and Marko Peltoniemi and Saari, {Teijo I.}",

year = "2021",

month = jun,

day = "7",

doi = "10.1371/journal.pone.0252626",

language = "English",

volume = "16",

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Brinck, ECV, Virtanen, T, Mäkelä, S, Soini, V, Hynninen, V-V, Mulo, J, Savolainen, U, Rantakokko, J, Maisniemi, K, Liukas, A, Olkkola, KT, Kontinen, V, Tarkkila, P, Peltoniemi, M & Saari, TI 2021, 'S-ketamine in patient-controlled analgesia reduces opioid consumption in a dose-dependent manner after major lumbar fusion surgery: A randomized, double-blind, placebo-controlled clinical trial', PLoS One, vol. 16, no. 6, 0252626. https://doi.org/10.1371/journal.pone.0252626

S-ketamine in patient-controlled analgesia reduces opioid consumption in a dose-dependent manner after major lumbar fusion surgery: A randomized, double-blind, placebo-controlled clinical trial. / Brinck, Elina C. V.; Virtanen, Taru; Mäkelä, Sanna et al.
In: PLoS One, Vol. 16, No. 6, 0252626, 07.06.2021.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - S-ketamine in patient-controlled analgesia reduces opioid consumption in a dose-dependent manner after major lumbar fusion surgery

T2 - A randomized, double-blind, placebo-controlled clinical trial

AU - Brinck, Elina C. V.

AU - Virtanen, Taru

AU - Mäkelä, Sanna

AU - Soini, Venla

AU - Hynninen, Ville-Veikko

AU - Mulo, Jukka

AU - Savolainen, Urmas

AU - Rantakokko, Juho

AU - Maisniemi, Kreu

AU - Liukas, Antti

AU - Olkkola, Klaus T.

AU - Kontinen, Vesa

AU - Tarkkila, Pekka

AU - Peltoniemi, Marko

AU - Saari, Teijo I.

PY - 2021/6/7

Y1 - 2021/6/7

KW - ACUTE POSTOPERATIVE PAIN

KW - ADDING KETAMINE

KW - MORPHINE

KW - PHARMACODYNAMICS

KW - PHARMACOKINETICS

KW - COMBINATION

KW - RISK

KW - AGE

KW - 3126 Surgery, anesthesiology, intensive care, radiology

U2 - 10.1371/journal.pone.0252626

DO - 10.1371/journal.pone.0252626

M3 - Article

SN - 1932-6203

VL - 16

JO - PLoS One

JF - PLoS One

IS - 6

M1 - 0252626

ER -