SARS-CoV-2 Infection of Human Neurons Is TMPRSS2 Independent, Requires Endosomal Cell Entry, and Can Be Blocked by Inhibitors of Host Phosphoinositol-5 Kinase

Pinja Kettunen; Angelina Lesnikova; Noora Räsänen; Ravi Ojha; Leena Palmunen; Markku Laakso; Sarka Lehtonen; Johanna Kuusisto; Olli Pietiläinen; Saber H. Saber; Merja Joensuu; Olli P. Vapalahti; Jari Koistinaho; Taisia Rolova; Giuseppe Balistreri

doi:10.1128/jvi.00144-23

SARS-CoV-2 Infection of Human Neurons Is TMPRSS2 Independent, Requires Endosomal Cell Entry, and Can Be Blocked by Inhibitors of Host Phosphoinositol-5 Kinase

Pinja Kettunen, Angelina Lesnikova, Noora Räsänen, Ravi Ojha, Leena Palmunen, Markku Laakso, Sarka Lehtonen, Johanna Kuusisto, Olli Pietiläinen, Saber H. Saber, Merja Joensuu, Olli P. Vapalahti, Jari Koistinaho, Taisia Rolova, Giuseppe Balistreri

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Article number	e0014423
Journal	Journal of Virology
Volume	97
Issue number	4
Number of pages	16
ISSN	0022-538X
DOIs	https://doi.org/10.1128/jvi.00144-23
Publication status	Published - 27 Apr 2023
MoE publication type	A1 Journal article-refereed

Fields of Science

11832 Microbiology and virology

Access to Document

10.1128/jvi.00144-23

jvi.00144-23Final published version, 4.2 MBLicence: CC BY

Cite this

Kettunen, P., Lesnikova, A., Räsänen, N., Ojha, R., Palmunen, L., Laakso, M., Lehtonen, S., Kuusisto, J., Pietiläinen, O., Saber, S. H., Joensuu, M., Vapalahti, O. P., Koistinaho, J., Rolova, T., & Balistreri, G. (2023). SARS-CoV-2 Infection of Human Neurons Is TMPRSS2 Independent, Requires Endosomal Cell Entry, and Can Be Blocked by Inhibitors of Host Phosphoinositol-5 Kinase. Journal of Virology, 97(4), Article e0014423. https://doi.org/10.1128/jvi.00144-23

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title = "SARS-CoV-2 Infection of Human Neurons Is TMPRSS2 Independent, Requires Endosomal Cell Entry, and Can Be Blocked by Inhibitors of Host Phosphoinositol-5 Kinase",

keywords = "Covid-19, Pik5, SARS-CoV-2, Apilimod, Astrocyte, Brain, Central nervous system infections, iPSC, long COVID, Neuron, 11832 Microbiology and virology",

author = "Pinja Kettunen and Angelina Lesnikova and Noora R{\"a}s{\"a}nen and Ravi Ojha and Leena Palmunen and Markku Laakso and Sarka Lehtonen and Johanna Kuusisto and Olli Pietil{\"a}inen and Saber, {Saber H.} and Merja Joensuu and Vapalahti, {Olli P.} and Jari Koistinaho and Taisia Rolova and Giuseppe Balistreri",

year = "2023",

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Kettunen, P, Lesnikova, A, Räsänen, N , Ojha, R, Palmunen, L, Laakso, M, Lehtonen, S, Kuusisto, J, Pietiläinen, O, Saber, SH, Joensuu, M, Vapalahti, OP , Koistinaho, J , Rolova, T & Balistreri, G 2023, 'SARS-CoV-2 Infection of Human Neurons Is TMPRSS2 Independent, Requires Endosomal Cell Entry, and Can Be Blocked by Inhibitors of Host Phosphoinositol-5 Kinase', Journal of Virology, vol. 97, no. 4, e0014423. https://doi.org/10.1128/jvi.00144-23

TY - JOUR

T1 - SARS-CoV-2 Infection of Human Neurons Is TMPRSS2 Independent, Requires Endosomal Cell Entry, and Can Be Blocked by Inhibitors of Host Phosphoinositol-5 Kinase

AU - Kettunen, Pinja

AU - Lesnikova, Angelina

AU - Räsänen, Noora

AU - Ojha, Ravi

AU - Palmunen, Leena

AU - Laakso, Markku

AU - Lehtonen, Sarka

AU - Kuusisto, Johanna

AU - Pietiläinen, Olli

AU - Saber, Saber H.

AU - Joensuu, Merja

AU - Vapalahti, Olli P.

AU - Koistinaho, Jari

AU - Rolova, Taisia

AU - Balistreri, Giuseppe

PY - 2023/4/27

Y1 - 2023/4/27

KW - Covid-19

KW - Pik5

KW - SARS-CoV-2

KW - Apilimod

KW - Astrocyte

KW - Brain

KW - Central nervous system infections

KW - iPSC

KW - long COVID

KW - Neuron

KW - 11832 Microbiology and virology

U2 - 10.1128/jvi.00144-23

DO - 10.1128/jvi.00144-23

M3 - Article

C2 - 37039676

SN - 0022-538X

VL - 97

JO - Journal of Virology

JF - Journal of Virology

IS - 4

M1 - e0014423

ER -