Screening for Early Gastric Cancer Using a Noninvasive Urine Metabolomics Approach

Hyuk Nam Kwon, Hyuk Lee, Ji Won Park, Young-Ho Kim, Sunghyouk Park, Jae J. Kim

Research output: Contribution to journalArticleScientificpeer-review

Abstract

The early detection of gastric cancer (GC) could decrease its incidence and mortality. However, there are currently no accurate noninvasive markers for GC screening. Therefore, we developed a noninvasive diagnostic approach, employing urine nuclear magnetic resonance (NMR) metabolomics, to discover putative metabolic markers associated with GC. Changes in urine metabolite levels during oncogenesis were evaluated using samples from 103 patients with GC and 100 age- and sex-matched healthy controls. Approximately 70% of the patients with GC (n = 69) had stage I GC, with the majority (n = 56) having intramucosal cancer. A multivariate statistical analysis of the urine NMR data well discriminated between the patient and control groups and revealed nine metabolites, including alanine, citrate, creatine, creatinine, glycerol, hippurate, phenylalanine, taurine, and 3-hydroxybutyrate, that contributed to the difference. A diagnostic performance test with a separate validation set exhibited a sensitivity and specificity of more than 90%, even with the intramucosal cancer samples only. In conclusion, the NMR-based urine metabolomics approach may have potential as a convenient screening method for the early detection of GC and may facilitate consequent endoscopic examination through risk stratification.
Original languageEnglish
Article number2904
JournalCancers
Volume12
Issue number10
Number of pages16
ISSN2072-6694
DOIs
Publication statusPublished - 9 Oct 2020
MoE publication typeA1 Journal article-refereed

Fields of Science

  • BIOMARKERS
  • CA 72-4
  • CARCINOEMBRYONIC ANTIGEN
  • CEA
  • CREATININE
  • EARLY-DIAGNOSIS
  • ENDOSCOPY
  • EXPRESSION
  • MANAGEMENT
  • SPECTROMETRY
  • gastric cancer
  • metabolomics
  • screening
  • urine
  • 3122 Cancers
  • 3111 Biomedicine

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