Selectivity in the efflux of glucuronides by human transporters: MRP4 is highly active toward 4-methylumbelliferone and 1-naphthol glucuronides, while MRP3 exhibits stereoselective propranolol glucuronide transport

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalMolecular Pharmaceutics
Volume14
Issue number10
Pages (from-to)3299-3311
Number of pages13
ISSN1543-8384
DOIs
Publication statusPublished - Oct 2017
MoE publication typeA1 Journal article-refereed

Fields of Science

  • hydroxypyrene
  • 1-naphthol
  • MRP2/ABCC2
  • ABCG2/BCRP
  • MRP3/ABCC3
  • MRP4/ABCC4
  • HUMAN UDP-GLUCURONOSYLTRANSFERASES
  • CANCER RESISTANCE PROTEIN
  • BASOLATERAL EFFLUX
  • DRUG DEVELOPMENT
  • SMALL-INTESTINE
  • METABOLISM
  • RAT
  • PHARMACOKINETICS
  • 1-HYDROXYPYRENE
  • EXCRETION
  • 317 Pharmacy

Cite this

@article{b23243597c5b4e289d615337e726aa6f,
title = "Selectivity in the efflux of glucuronides by human transporters: MRP4 is highly active toward 4-methylumbelliferone and 1-naphthol glucuronides, while MRP3 exhibits stereoselective propranolol glucuronide transport",
keywords = "hydroxypyrene, 1-naphthol, MRP2/ABCC2, ABCG2/BCRP, MRP3/ABCC3, MRP4/ABCC4, HUMAN UDP-GLUCURONOSYLTRANSFERASES, CANCER RESISTANCE PROTEIN, BASOLATERAL EFFLUX, DRUG DEVELOPMENT, SMALL-INTESTINE, METABOLISM, RAT, PHARMACOKINETICS, 1-HYDROXYPYRENE, EXCRETION, 317 Pharmacy",
author = "Erkka J{\"a}rvinen and Johanna Troberg and Heidi Kidron and Moshe Finel",
year = "2017",
month = "10",
doi = "10.1021/acs.molpharmaceut.7b00366",
language = "English",
volume = "14",
pages = "3299--3311",
journal = "Molecular Pharmaceutics",
issn = "1543-8384",
publisher = "American Chemical Society",
number = "10",

}

TY - JOUR

T1 - Selectivity in the efflux of glucuronides by human transporters

T2 - MRP4 is highly active toward 4-methylumbelliferone and 1-naphthol glucuronides, while MRP3 exhibits stereoselective propranolol glucuronide transport

AU - Järvinen, Erkka

AU - Troberg, Johanna

AU - Kidron, Heidi

AU - Finel, Moshe

PY - 2017/10

Y1 - 2017/10

KW - hydroxypyrene

KW - 1-naphthol

KW - MRP2/ABCC2

KW - ABCG2/BCRP

KW - MRP3/ABCC3

KW - MRP4/ABCC4

KW - HUMAN UDP-GLUCURONOSYLTRANSFERASES

KW - CANCER RESISTANCE PROTEIN

KW - BASOLATERAL EFFLUX

KW - DRUG DEVELOPMENT

KW - SMALL-INTESTINE

KW - METABOLISM

KW - RAT

KW - PHARMACOKINETICS

KW - 1-HYDROXYPYRENE

KW - EXCRETION

KW - 317 Pharmacy

U2 - 10.1021/acs.molpharmaceut.7b00366

DO - 10.1021/acs.molpharmaceut.7b00366

M3 - Article

VL - 14

SP - 3299

EP - 3311

JO - Molecular Pharmaceutics

JF - Molecular Pharmaceutics

SN - 1543-8384

IS - 10

ER -