Serology assessment of antibody response to SARS-CoV-2 in patients with COVID-19 by rapid IgM/IgG antibody test

Yang De Marinis, Torgny Sunnerhagen, Pradeep Bompada, Anna Bläckberg, Runtao Yang, Joel Svensson, Ola Ekström, Karl-Fredrik Eriksson, Ola Hansson, Leif Groop, Isabel Gonçalves, Magnus Rasmussen

Research output: Contribution to journalArticleScientificpeer-review


The coronavirus disease 2019 (COVID-19) pandemic has created a global health- and economic crisis. Detection of antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes COVID-19 by serological methods is important to diagnose a current or resolved infection. In this study, we applied a rapid COVID-19 IgM/IgG antibody test and performed serology assessment of antibody response to SARS-CoV-2. In PCR-confirmed COVID-19 patients (n = 45), the total antibody detection rate is 92% in hospitalized patients and 79% in non-hospitalized patients. The total IgM and IgG detection is 63% in patients with 2 weeks disease duration; and 91% in hospitalized patients with >2 weeks disease duration. We also compared different blood sample types and suggest a higher sensitivity by serum/plasma over whole blood. Test specificity was determined to be 97% on 69 sera/plasma samples collected between 2016-2018. Our study provides a comprehensive validation of the rapid COVID-19 IgM/IgG serology test, and mapped antibody detection patterns in association with disease progress and hospitalization. Our results support that the rapid COVID-19 IgM/IgG test may be applied to assess the COVID-19 status both at the individual and at a population level. © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Original languageEnglish
Article number1821513
JournalInfection ecology & epidemiology
Issue number1
Number of pages8
Publication statusPublished - 2020
MoE publication typeA1 Journal article-refereed

Fields of Science

  • antibody test
  • COVID-19
  • disease severity and duration
  • IgM and IgG
  • SARS-CoV-2
  • serology assessment
  • immunoglobulin G antibody
  • immunoglobulin M antibody
  • aged
  • antibody response
  • Article
  • clinical article
  • cohort analysis
  • controlled study
  • coronavirus disease 2019
  • disease course
  • disease duration
  • female
  • hospitalization
  • human
  • immunoassay
  • male
  • nonhuman
  • population research
  • prospective study
  • real time polymerase chain reaction
  • sensitivity and specificity
  • Severe acute respiratory syndrome coronavirus 2
  • validation study
  • 3111 Biomedicine

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