Short‐term direct contact with soil and plant materials leads to an immediate increase in diversity of skin microbiota

Mira Grönroos, Anirudra Parajuli, Olli H. Laitinen, Marja Irmeli Roslund, Heli Kristiina Vari, Heikki Hyöty, Riikka Puhakka, Aki Tapio Sinkkonen

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Immune-mediated diseases have increased during the last decades in urban environments. The hygiene hypothesis suggests that increased hygiene level and reduced contacts with natural biodiversity are related to the increase in immune-mediated diseases. We tested whether short-time contact with microbiologically diverse nature-based materials immediately change bacterial diversity on human skin. We tested direct skin contact, as two volunteers rubbed their hands with sixteen soil and plant based materials, and an exposure via fabric packets filled with moss material. Skin swabs were taken before and after both exposures. Next-generation sequencing showed that exposures increased, at least temporarily, the total diversity of skin microbiota and the diversity of Acidobacteria, Actinobacteria, Bacteroidetes, Proteobacteria and Alpha-, Beta- and Gammaproteobacteria suggesting that contact with nature-based materials modify skin microbiome and increase skin microbial diversity. Until now, approaches to cure or prevent immune system disorders using microbe-based treatments have been limited to use of a few microbial species. We propose that nature-based materials with high natural diversity, such as the materials tested here, might be more effective in modifying human skin microbiome, and eventually, in reducing immune system disorders. Future studies should investigate how long-term changes in skin microbiota are achieved and if the exposure induces beneficial changes in the immune system markers.

Original languageEnglish
Article number645
JournalMicrobiologyOpen
Volume8
Issue number3
Number of pages13
ISSN2045-8827
DOIs
Publication statusPublished - Mar 2019
MoE publication typeA1 Journal article-refereed

Fields of Science

  • 1183 Plant biology, microbiology, virology
  • biodiversity hypothesis
  • human health
  • hygiene hypothesis
  • nature-based materials
  • GUT MICROBIOTA
  • RIBOSOMAL-RNA
  • HYGIENE HYPOTHESIS
  • ALLERGIC DISEASES
  • ATOPIC-DERMATITIS
  • SEQUENCE DATA
  • AUTOIMMUNE
  • PROBIOTICS
  • HEALTH
  • COMMUNITIES

Cite this

@article{ceee4eb2b807428d8aeebc9691622c13,
title = "Short‐term direct contact with soil and plant materials leads to an immediate increase in diversity of skin microbiota",
abstract = "Immune-mediated diseases have increased during the last decades in urban environments. The hygiene hypothesis suggests that increased hygiene level and reduced contacts with natural biodiversity are related to the increase in immune-mediated diseases. We tested whether short-time contact with microbiologically diverse nature-based materials immediately change bacterial diversity on human skin. We tested direct skin contact, as two volunteers rubbed their hands with sixteen soil and plant based materials, and an exposure via fabric packets filled with moss material. Skin swabs were taken before and after both exposures. Next-generation sequencing showed that exposures increased, at least temporarily, the total diversity of skin microbiota and the diversity of Acidobacteria, Actinobacteria, Bacteroidetes, Proteobacteria and Alpha-, Beta- and Gammaproteobacteria suggesting that contact with nature-based materials modify skin microbiome and increase skin microbial diversity. Until now, approaches to cure or prevent immune system disorders using microbe-based treatments have been limited to use of a few microbial species. We propose that nature-based materials with high natural diversity, such as the materials tested here, might be more effective in modifying human skin microbiome, and eventually, in reducing immune system disorders. Future studies should investigate how long-term changes in skin microbiota are achieved and if the exposure induces beneficial changes in the immune system markers.",
keywords = "1183 Plant biology, microbiology, virology, biodiversity hypothesis, human health, hygiene hypothesis, nature-based materials, GUT MICROBIOTA, RIBOSOMAL-RNA, HYGIENE HYPOTHESIS, ALLERGIC DISEASES, ATOPIC-DERMATITIS, SEQUENCE DATA, AUTOIMMUNE, PROBIOTICS, HEALTH, COMMUNITIES",
author = "Mira Gr{\"o}nroos and Anirudra Parajuli and Laitinen, {Olli H.} and Roslund, {Marja Irmeli} and Vari, {Heli Kristiina} and Heikki Hy{\"o}ty and Riikka Puhakka and Sinkkonen, {Aki Tapio}",
year = "2019",
month = "3",
doi = "10.1002/mbo3.645",
language = "English",
volume = "8",
journal = "MicrobiologyOpen",
issn = "2045-8827",
publisher = "Wiley Blackwell",
number = "3",

}

Short‐term direct contact with soil and plant materials leads to an immediate increase in diversity of skin microbiota. / Grönroos, Mira ; Parajuli, Anirudra; Laitinen, Olli H.; Roslund, Marja Irmeli; Vari, Heli Kristiina; Hyöty, Heikki; Puhakka, Riikka ; Sinkkonen, Aki Tapio.

In: MicrobiologyOpen, Vol. 8, No. 3, 645, 03.2019.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Short‐term direct contact with soil and plant materials leads to an immediate increase in diversity of skin microbiota

AU - Grönroos, Mira

AU - Parajuli, Anirudra

AU - Laitinen, Olli H.

AU - Roslund, Marja Irmeli

AU - Vari, Heli Kristiina

AU - Hyöty, Heikki

AU - Puhakka, Riikka

AU - Sinkkonen, Aki Tapio

PY - 2019/3

Y1 - 2019/3

N2 - Immune-mediated diseases have increased during the last decades in urban environments. The hygiene hypothesis suggests that increased hygiene level and reduced contacts with natural biodiversity are related to the increase in immune-mediated diseases. We tested whether short-time contact with microbiologically diverse nature-based materials immediately change bacterial diversity on human skin. We tested direct skin contact, as two volunteers rubbed their hands with sixteen soil and plant based materials, and an exposure via fabric packets filled with moss material. Skin swabs were taken before and after both exposures. Next-generation sequencing showed that exposures increased, at least temporarily, the total diversity of skin microbiota and the diversity of Acidobacteria, Actinobacteria, Bacteroidetes, Proteobacteria and Alpha-, Beta- and Gammaproteobacteria suggesting that contact with nature-based materials modify skin microbiome and increase skin microbial diversity. Until now, approaches to cure or prevent immune system disorders using microbe-based treatments have been limited to use of a few microbial species. We propose that nature-based materials with high natural diversity, such as the materials tested here, might be more effective in modifying human skin microbiome, and eventually, in reducing immune system disorders. Future studies should investigate how long-term changes in skin microbiota are achieved and if the exposure induces beneficial changes in the immune system markers.

AB - Immune-mediated diseases have increased during the last decades in urban environments. The hygiene hypothesis suggests that increased hygiene level and reduced contacts with natural biodiversity are related to the increase in immune-mediated diseases. We tested whether short-time contact with microbiologically diverse nature-based materials immediately change bacterial diversity on human skin. We tested direct skin contact, as two volunteers rubbed their hands with sixteen soil and plant based materials, and an exposure via fabric packets filled with moss material. Skin swabs were taken before and after both exposures. Next-generation sequencing showed that exposures increased, at least temporarily, the total diversity of skin microbiota and the diversity of Acidobacteria, Actinobacteria, Bacteroidetes, Proteobacteria and Alpha-, Beta- and Gammaproteobacteria suggesting that contact with nature-based materials modify skin microbiome and increase skin microbial diversity. Until now, approaches to cure or prevent immune system disorders using microbe-based treatments have been limited to use of a few microbial species. We propose that nature-based materials with high natural diversity, such as the materials tested here, might be more effective in modifying human skin microbiome, and eventually, in reducing immune system disorders. Future studies should investigate how long-term changes in skin microbiota are achieved and if the exposure induces beneficial changes in the immune system markers.

KW - 1183 Plant biology, microbiology, virology

KW - biodiversity hypothesis

KW - human health

KW - hygiene hypothesis

KW - nature-based materials

KW - GUT MICROBIOTA

KW - RIBOSOMAL-RNA

KW - HYGIENE HYPOTHESIS

KW - ALLERGIC DISEASES

KW - ATOPIC-DERMATITIS

KW - SEQUENCE DATA

KW - AUTOIMMUNE

KW - PROBIOTICS

KW - HEALTH

KW - COMMUNITIES

U2 - 10.1002/mbo3.645

DO - 10.1002/mbo3.645

M3 - Article

VL - 8

JO - MicrobiologyOpen

JF - MicrobiologyOpen

SN - 2045-8827

IS - 3

M1 - 645

ER -