Sigma-1 receptor agonist PRE084 is protective against mutant huntingtin-induced cell degeneration: involvement of calpastatin and the NF-kappa B pathway

A. Hyrskyluoto, I. Pulli, K. Tornqvist, T. Huu Ho, L. Korhonen, D. Lindholm

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalCell Death and Disease
Volume4
Issue numberArticle Number: e646
Number of pages9
ISSN2041-4889
DOIs
Publication statusPublished - May 2013
MoE publication typeA1 Journal article-refereed

Fields of Science

  • Sigma-1 receptor
  • NF-kappa B
  • calpastatin
  • oxidative stress
  • HD
  • X-LINKED INHIBITOR
  • APOPTOSIS PROTEIN
  • PARKINSONS-DISEASE
  • LOW-DENSITY
  • RAT-BRAIN
  • ACTIVATION
  • DEATH
  • NEURODEGENERATION
  • MECHANISMS
  • EXPRESSION
  • 3111 Biomedicine

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