Simple 3D printed stainless steel microreactors for online mass spectrometric analysis

Gianmario Scotti, Sofia M.E. Nilsson, Ville-Pekka Matilainen, Markus Haapala, Gustav Boije af Gennäs, Jari Yli-Kauhaluoma, Antti Salminen, Tapio Kotiaho

Research output: Contribution to journalArticleScientificpeer-review


A simple flow chemistry microreactor with an electrospray ionization tip for real time mass spectrometric reaction monitoring is introduced. The microreactor was fabricated by a laser-based additive manufacturing technique from acid-resistant stainless steel 316L. The functionality of the microreactor was investigated by using an inverse electron demand Diels-Alder and subsequent retro Diels-Alder reaction for testing. Challenges and problems encountered are discussed and improvements proposed. Adsorption of reagents to the rough stainless steel channel walls, short length of the reaction channel, and making a proper ESI tip present challenges, but the microreactor is potentially useful as a disposable device.
Original languageEnglish
Article number02002
Issue number7
Number of pages7
Publication statusPublished - 2 Jul 2019
MoE publication typeA1 Journal article-refereed

Fields of Science

  • 116 Chemical sciences

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