Simultaneous p53 and p16 Immunostaining for Molecular Subclassification of Head and Neck Squamous Cell Carcinomas

Pihla Pakkanen; Antti Silvoniemi; Katri Aro; Leif Bäck; Heikki Irjala; Leena-Maija Aaltonen; Jaana Hagström; Caj Haglund; Jukka Laine; Heikki Minn; Jutta Huvila

doi:10.1007/s12105-024-01680-z

Simultaneous p53 and p16 Immunostaining for Molecular Subclassification of Head and Neck Squamous Cell Carcinomas

Pihla Pakkanen, Antti Silvoniemi, Katri Aro, Leif Bäck, Heikki Irjala, Leena-Maija Aaltonen, Jaana Hagström, Caj Haglund, Jukka Laine, Heikki Minn, Jutta Huvila

Research output: Contribution to journal › Article › Scientific › peer-review

Abstract

Purpose: Our aim was to assess the ability of simultaneous immunohistochemical staining (IHC) for p16 and p53 to accurately subclassify head and neck squamous cell carcinomas (HNSCC) as HPV-associated (HPV-A) versus HPV-independent (HPV-I) and compare p53 IHC staining patterns to TP53 mutation status, p16 IHC positivity and HPV status.

Original language	English
Article number	73
Journal	Head and neck pathology
Volume	18
Issue number	1
Number of pages	10
ISSN	1936-055X
DOIs	https://doi.org/10.1007/s12105-024-01680-z
Publication status	Published - 2024
MoE publication type	A1 Journal article-refereed

Bibliographical note

Publisher Copyright:
© The Author(s) 2024.

Fields of Science

Head and neck SCC
HPV-associated
HPV-independent
p16
p53
3125 Otorhinolaryngology, ophthalmology

Access to Document

10.1007/s12105-024-01680-z

s12105-024-01680-z (1)Final published version, 3.47 MBLicence: CC BY

Cite this

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abstract = "Purpose: Our aim was to assess the ability of simultaneous immunohistochemical staining (IHC) for p16 and p53 to accurately subclassify head and neck squamous cell carcinomas (HNSCC) as HPV-associated (HPV-A) versus HPV-independent (HPV-I) and compare p53 IHC staining patterns to TP53 mutation status, p16 IHC positivity and HPV status.",

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doi = "10.1007/s12105-024-01680-z",

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T1 - Simultaneous p53 and p16 Immunostaining for Molecular Subclassification of Head and Neck Squamous Cell Carcinomas

AU - Pakkanen, Pihla

AU - Silvoniemi, Antti

AU - Aro, Katri

AU - Bäck, Leif

AU - Irjala, Heikki

AU - Aaltonen, Leena-Maija

AU - Hagström, Jaana

AU - Haglund, Caj

AU - Laine, Jukka

AU - Minn, Heikki

AU - Huvila, Jutta

N1 - Publisher Copyright: © The Author(s) 2024.

PY - 2024

Y1 - 2024

N2 - Purpose: Our aim was to assess the ability of simultaneous immunohistochemical staining (IHC) for p16 and p53 to accurately subclassify head and neck squamous cell carcinomas (HNSCC) as HPV-associated (HPV-A) versus HPV-independent (HPV-I) and compare p53 IHC staining patterns to TP53 mutation status, p16 IHC positivity and HPV status.

AB - Purpose: Our aim was to assess the ability of simultaneous immunohistochemical staining (IHC) for p16 and p53 to accurately subclassify head and neck squamous cell carcinomas (HNSCC) as HPV-associated (HPV-A) versus HPV-independent (HPV-I) and compare p53 IHC staining patterns to TP53 mutation status, p16 IHC positivity and HPV status.

KW - Head and neck SCC

KW - HPV-associated

KW - HPV-independent

KW - p16

KW - p53

KW - 3125 Otorhinolaryngology, ophthalmology

U2 - 10.1007/s12105-024-01680-z

DO - 10.1007/s12105-024-01680-z

M3 - Article

C2 - 39110300

AN - SCOPUS:85200674141

SN - 1936-055X

VL - 18

JO - Head and neck pathology

JF - Head and neck pathology

IS - 1

M1 - 73

ER -