Simvastatin pretreatment reduces caspase-9 and RIPK1 protein activity in rat cardiac allograft ischemia-reperfusion

Raimo Tuuminen, Emil Holmstrom, Alireza Raissadati, Pipsa Saharinen, Eeva Rouvinen, Rainer Krebs, Karl B. Lemstrom

Research output: Contribution to journal › Article › Scientific › peer-review

Original languageEnglish
JournalTransplant Immunology
Volume37
Pages (from-to)40-45
Number of pages6
ISSN0966-3274
DOIs
Publication statusPublished - Jul 2016
MoE publication typeA1 Journal article-refereed

Fields of Science

  • Cardiac transplantation
  • Ischemia-reperfusion
  • Apoptosis
  • Necroptosis
  • Simvastatin
  • RANDOMIZED-TRIAL
  • HEART-TRANSPLANTATION
  • MYOCARDIAL DAMAGE
  • INJURY
  • DONOR
  • INFLAMMATION
  • NECROPTOSIS
  • HYPERCHOLESTEROLEMIA
  • NECROSIS
  • DEATH
  • 3126 Surgery, anesthesiology, intensive care, radiology
  • 3111 Biomedicine

Cite this

Tuuminen, Raimo ; Holmstrom, Emil ; Raissadati, Alireza ; Saharinen, Pipsa ; Rouvinen, Eeva ; Krebs, Rainer ; Lemstrom, Karl B. / Simvastatin pretreatment reduces caspase-9 and RIPK1 protein activity in rat cardiac allograft ischemia-reperfusion. In: Transplant Immunology. 2016 ; Vol. 37. pp. 40-45.
@article{b2a49c82ca074940a2dd548853b14266,
title = "Simvastatin pretreatment reduces caspase-9 and RIPK1 protein activity in rat cardiac allograft ischemia-reperfusion",
keywords = "Cardiac transplantation, Ischemia-reperfusion, Apoptosis, Necroptosis, Simvastatin, RANDOMIZED-TRIAL, HEART-TRANSPLANTATION, MYOCARDIAL DAMAGE, INJURY, DONOR, INFLAMMATION, NECROPTOSIS, HYPERCHOLESTEROLEMIA, NECROSIS, DEATH, 3126 Surgery, anesthesiology, intensive care, radiology, 3111 Biomedicine",
author = "Raimo Tuuminen and Emil Holmstrom and Alireza Raissadati and Pipsa Saharinen and Eeva Rouvinen and Rainer Krebs and Lemstrom, {Karl B.}",
year = "2016",
month = "7",
doi = "10.1016/j.trim.2016.05.001",
language = "English",
volume = "37",
pages = "40--45",
journal = "Transplant Immunology",
issn = "0966-3274",
publisher = "Elsevier Scientific Publ. Co",

}

Tuuminen, R, Holmstrom, E, Raissadati, A, Saharinen, P, Rouvinen, E, Krebs, R & Lemstrom, KB 2016, 'Simvastatin pretreatment reduces caspase-9 and RIPK1 protein activity in rat cardiac allograft ischemia-reperfusion', Transplant Immunology, vol. 37, pp. 40-45. https://doi.org/10.1016/j.trim.2016.05.001

Simvastatin pretreatment reduces caspase-9 and RIPK1 protein activity in rat cardiac allograft ischemia-reperfusion. / Tuuminen, Raimo; Holmstrom, Emil; Raissadati, Alireza; Saharinen, Pipsa; Rouvinen, Eeva; Krebs, Rainer; Lemstrom, Karl B.

In: Transplant Immunology, Vol. 37, 07.2016, p. 40-45.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Simvastatin pretreatment reduces caspase-9 and RIPK1 protein activity in rat cardiac allograft ischemia-reperfusion

AU - Tuuminen, Raimo

AU - Holmstrom, Emil

AU - Raissadati, Alireza

AU - Saharinen, Pipsa

AU - Rouvinen, Eeva

AU - Krebs, Rainer

AU - Lemstrom, Karl B.

PY - 2016/7

Y1 - 2016/7

KW - Cardiac transplantation

KW - Ischemia-reperfusion

KW - Apoptosis

KW - Necroptosis

KW - Simvastatin

KW - RANDOMIZED-TRIAL

KW - HEART-TRANSPLANTATION

KW - MYOCARDIAL DAMAGE

KW - INJURY

KW - DONOR

KW - INFLAMMATION

KW - NECROPTOSIS

KW - HYPERCHOLESTEROLEMIA

KW - NECROSIS

KW - DEATH

KW - 3126 Surgery, anesthesiology, intensive care, radiology

KW - 3111 Biomedicine

U2 - 10.1016/j.trim.2016.05.001

DO - 10.1016/j.trim.2016.05.001

M3 - Article

VL - 37

SP - 40

EP - 45

JO - Transplant Immunology

JF - Transplant Immunology

SN - 0966-3274

ER -

Tuuminen R, Holmstrom E, Raissadati A, Saharinen P, Rouvinen E, Krebs R et al. Simvastatin pretreatment reduces caspase-9 and RIPK1 protein activity in rat cardiac allograft ischemia-reperfusion. Transplant Immunology. 2016 Jul;37:40-45. https://doi.org/10.1016/j.trim.2016.05.001

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