Simvastatin profoundly impairs energy metabolism in primary human muscle cells

Selina Mäkinen; Neeta Datta; Yen H. Nguyen; Petro Kyrylenko; Markku Laakso; Heikki A. Koistinen

doi:10.1530/EC-20-0444

Simvastatin profoundly impairs energy metabolism in primary human muscle cells

Selina Mäkinen, Neeta Datta, Yen H. Nguyen, Petro Kyrylenko, Markku Laakso, Heikki A. Koistinen

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Endocrine Connections
Volume	9
Issue number	11
Pages (from-to)	1103-1113
Number of pages	11
ISSN	2049-3614
DOIs	https://doi.org/10.1530/EC-20-0444
Publication status	Published - Nov 2020
MoE publication type	A1 Journal article-refereed

Bibliographical note

Correction: Volume11, Issue: 7
Article Number: x200444
DOI: 10.1530/EC-20-0444e
Published: JUL 2022

Fields of Science

ATP production
glucose uptake
glycogen synthesis
glycolysis
HMG-CoA reductase inhibitor
insulin resistance
mitochondrial respiration
simvastatin
skeletal muscle
PROTEIN-KINASE-C
SKELETAL-MUSCLE
GLUCOSE-UPTAKE
CARDIOVASCULAR-DISEASE
STATINS
GLUT4
ACID
PHOSPHORYLATION
RESPIRATION
EXPRESSION
3121 General medicine, internal medicine and other clinical medicine

Access to Document

10.1530/EC-20-0444

[20493614 - Endocrine Connections] Simvastatin profoundly impairs energy metabolism in primary human muscle cellsFinal published version, 1.98 MBLicence: CC BY-NC-ND
Correction 2049-3614-EC-20-0444eFinal published version, 142 KBLicence: CC BY-NC-ND

Cite this

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title = "Simvastatin profoundly impairs energy metabolism in primary human muscle cells",

keywords = "ATP production, glucose uptake, glycogen synthesis, glycolysis, HMG-CoA reductase inhibitor, insulin resistance, mitochondrial respiration, simvastatin, skeletal muscle, PROTEIN-KINASE-C, SKELETAL-MUSCLE, GLUCOSE-UPTAKE, CARDIOVASCULAR-DISEASE, STATINS, GLUT4, ACID, PHOSPHORYLATION, RESPIRATION, EXPRESSION, 3121 General medicine, internal medicine and other clinical medicine",

author = "Selina M{\"a}kinen and Neeta Datta and Nguyen, {Yen H.} and Petro Kyrylenko and Markku Laakso and Koistinen, {Heikki A.}",

note = "Correction: Volume11, Issue: 7 Article Number: x200444 DOI: 10.1530/EC-20-0444e Published: JUL 2022",

year = "2020",

month = nov,

doi = "10.1530/EC-20-0444",

language = "English",

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TY - JOUR

T1 - Simvastatin profoundly impairs energy metabolism in primary human muscle cells

AU - Mäkinen, Selina

AU - Datta, Neeta

AU - Nguyen, Yen H.

AU - Kyrylenko, Petro

AU - Laakso, Markku

AU - Koistinen, Heikki A.

N1 - Correction: Volume11, Issue: 7 Article Number: x200444 DOI: 10.1530/EC-20-0444e Published: JUL 2022

PY - 2020/11

Y1 - 2020/11

KW - ATP production

KW - glucose uptake

KW - glycogen synthesis

KW - glycolysis

KW - HMG-CoA reductase inhibitor

KW - insulin resistance

KW - mitochondrial respiration

KW - simvastatin

KW - skeletal muscle

KW - PROTEIN-KINASE-C

KW - SKELETAL-MUSCLE

KW - GLUCOSE-UPTAKE

KW - CARDIOVASCULAR-DISEASE

KW - STATINS

KW - GLUT4

KW - ACID

KW - PHOSPHORYLATION

KW - RESPIRATION

KW - EXPRESSION

KW - 3121 General medicine, internal medicine and other clinical medicine

U2 - 10.1530/EC-20-0444

DO - 10.1530/EC-20-0444

M3 - Article

SN - 2049-3614

VL - 9

SP - 1103

EP - 1113

JO - Endocrine Connections

JF - Endocrine Connections

IS - 11

ER -