Single-cell tumor-immune microenvironment of BRCA1/2 mutated high-grade serous ovarian cancer

I-M Launonen; N. Lyytikäinen; J. Casado; E. A. Anttila; A. Szabo; U-M Haltia; C. A. Jacobson; J. R. Lin; Z. Maliga; B. E. Howitt; K. C. Strickland; S. Santagata; K. Elias; A. D. D'Andrea; P. A. Konstantinopoulos; P. K. Sorger; A. Färkkilä

doi:10.21203/rs.3.rs-257705/v2

Single-cell tumor-immune microenvironment of BRCA1/2 mutated high-grade serous ovarian cancer

I-M Launonen, N. Lyytikäinen, J. Casado, E. A. Anttila, A. Szabo, U-M Haltia, C. A. Jacobson, J. R. Lin, Z. Maliga, B. E. Howitt, K. C. Strickland, S. Santagata, K. Elias, A. D. D'Andrea, P. A. Konstantinopoulos, P. K. Sorger, A. Färkkilä

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Article number	835
Journal	Nature Communications
Volume	13
Issue number	1
Number of pages	14
ISSN	2041-1723
DOIs	https://doi.org/10.21203/rs.3.rs-257705/v2 https://doi.org/10.1038/s41467-022-28389-3
Publication status	Published - Dec 2022
MoE publication type	A1 Journal article-refereed

Fields of Science

T-CELLS
CHEMORESISTANCE
PROLIFERATION
CARCINOMA
COHORT
STROMA
3123 Gynaecology and paediatrics
3122 Cancers

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s41467-022-28389-3Final published version, 5.47 MBLicence: CC BY

Discovery and therapeutic exploitation of immunological vulnerabilities in ovarian cancer
Färkkilä, A., Casado, J., Perez Villatoro, F. R., Pietilä, E., Nagaraj, A. & Launonen, I. P.
SUOMEN AKATEMIA
01/01/2021 → 31/12/2024
Project: University of Helsinki Three-Year Research Project

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Launonen, I-M., Lyytikäinen, N., Casado, J., Anttila, E. A., Szabo, A., Haltia, U-M., Jacobson, C. A., Lin, J. R., Maliga, Z., Howitt, B. E., Strickland, K. C., Santagata, S., Elias, K., D'Andrea, A. D., Konstantinopoulos, P. A., Sorger, P. K., & Färkkilä, A. (2022). Single-cell tumor-immune microenvironment of BRCA1/2 mutated high-grade serous ovarian cancer. Nature Communications, 13(1), [835]. https://doi.org/10.21203/rs.3.rs-257705/v2, https://doi.org/10.1038/s41467-022-28389-3

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title = "Single-cell tumor-immune microenvironment of BRCA1/2 mutated high-grade serous ovarian cancer",

keywords = "T-CELLS, CHEMORESISTANCE, PROLIFERATION, CARCINOMA, COHORT, STROMA, 3123 Gynaecology and paediatrics, 3122 Cancers",

author = "I-M Launonen and N. Lyytik{\"a}inen and J. Casado and Anttila, {E. A.} and A. Szabo and U-M Haltia and Jacobson, {C. A.} and Lin, {J. R.} and Z. Maliga and Howitt, {B. E.} and Strickland, {K. C.} and S. Santagata and K. Elias and D'Andrea, {A. D.} and Konstantinopoulos, {P. A.} and Sorger, {P. K.} and A. F{\"a}rkkil{\"a}",

year = "2022",

month = dec,

doi = "10.21203/rs.3.rs-257705/v2",

language = "English",

volume = "13",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Publishing Group",

number = "1",

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Launonen, I-M, Lyytikäinen, N, Casado, J, Anttila, EA, Szabo, A, Haltia, U-M, Jacobson, CA, Lin, JR, Maliga, Z, Howitt, BE, Strickland, KC, Santagata, S, Elias, K, D'Andrea, AD, Konstantinopoulos, PA, Sorger, PK & Färkkilä, A 2022, 'Single-cell tumor-immune microenvironment of BRCA1/2 mutated high-grade serous ovarian cancer', Nature Communications, vol. 13, no. 1, 835. https://doi.org/10.21203/rs.3.rs-257705/v2, https://doi.org/10.1038/s41467-022-28389-3

TY - JOUR

T1 - Single-cell tumor-immune microenvironment of BRCA1/2 mutated high-grade serous ovarian cancer

AU - Launonen, I-M

AU - Lyytikäinen, N.

AU - Casado, J.

AU - Anttila, E. A.

AU - Szabo, A.

AU - Haltia, U-M

AU - Jacobson, C. A.

AU - Lin, J. R.

AU - Maliga, Z.

AU - Howitt, B. E.

AU - Strickland, K. C.

AU - Santagata, S.

AU - Elias, K.

AU - D'Andrea, A. D.

AU - Konstantinopoulos, P. A.

AU - Sorger, P. K.

AU - Färkkilä, A.

PY - 2022/12

Y1 - 2022/12

KW - T-CELLS

KW - CHEMORESISTANCE

KW - PROLIFERATION

KW - CARCINOMA

KW - COHORT

KW - STROMA

KW - 3123 Gynaecology and paediatrics

KW - 3122 Cancers

U2 - 10.21203/rs.3.rs-257705/v2

DO - 10.21203/rs.3.rs-257705/v2

M3 - Article

VL - 13

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 835

ER -

Single-cell tumor-immune microenvironment of BRCA1/2 mutated high-grade serous ovarian cancer

Fields of Science

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Projects

Discovery and therapeutic exploitation of immunological vulnerabilities in ovarian cancer

Cite this