Slow endogenous activity transients and developmental expression of K+-Cl- cotransporter 2 in the immature human cortex

Research output: Contribution to journalArticleScientificpeer-review

Abstract

"Spontaneous transients of correlated activity are a characteristic feature of immature brain structures, where they are thought to be crucial for the establishment of precise neuronal connectivity. Studies on experimental animals have shown that this kind of early activity in cortical structures is composed of long-lasting, intermittent network events, which undergo a developmental decline that is closely paralleled by the maturation of GABAergic inhibition. In order to examine whether similar events occur in the immature human cortex, we performed direct current-coupled electroencephalography (EEG) recordings from sleeping preterm babies. We show now that much of the preterm EEG activity is confined to spontaneous, slow activity transients. These transients are characterized by a large voltage deflection that nests prominent oscillatory activity in several frequency bands covering the whole frequency spectrum of the preterm EEG (< 0.1-30 Hz). The slow voltage deflections had an amplitude of up to 800 mu V. Most of these 'giant' events originated in the temporo-occipital areas, with a maximum rate of about 8/min, and their occurrence as well as amplitude showed a decline by the time of normal birth. In age-matched fetal brain tissue, this decrease in the spontaneous activity transients was associated with a developmental up-regulation of the neuronal chloride extruder K+-Cl- cotransporter 2, a crucial molecule for the generation of inhibitory GABAergic Cl- currents. Our work indicates that slow endogenous activity transients in the immature human neocortex are mostly confined to the prenatal stage and appear to be terminated in parallel with the maturation of functional GABAergic inhibition."
Original languageEnglish
JournalEuropean Journal of Neuroscience
Volume22
Issue number11
Pages (from-to)2799-2804
Number of pages6
ISSN0953-816X
DOIs
Publication statusPublished - 2005
MoE publication typeA1 Journal article-refereed

Fields of Science

  • cortical development
  • DC-EEG
  • intracellular chloride
  • KCC2
  • preterm EEG
  • trace alternant
  • FULL-TERM NEWBORNS
  • NEOCORTICAL NEURONS
  • KCC2 EXPRESSION
  • PRETERM INFANTS
  • CALCIUM WAVES
  • FETAL-BRAIN
  • GABA
  • OSCILLATIONS
  • HIPPOCAMPUS
  • MATURATION
  • 118 Biological sciences
  • 311 Basic medicine

Cite this

@article{7205862685f9449e9f1371d91a9eee04,
title = "Slow endogenous activity transients and developmental expression of K+-Cl- cotransporter 2 in the immature human cortex",
abstract = "{"}Spontaneous transients of correlated activity are a characteristic feature of immature brain structures, where they are thought to be crucial for the establishment of precise neuronal connectivity. Studies on experimental animals have shown that this kind of early activity in cortical structures is composed of long-lasting, intermittent network events, which undergo a developmental decline that is closely paralleled by the maturation of GABAergic inhibition. In order to examine whether similar events occur in the immature human cortex, we performed direct current-coupled electroencephalography (EEG) recordings from sleeping preterm babies. We show now that much of the preterm EEG activity is confined to spontaneous, slow activity transients. These transients are characterized by a large voltage deflection that nests prominent oscillatory activity in several frequency bands covering the whole frequency spectrum of the preterm EEG (< 0.1-30 Hz). The slow voltage deflections had an amplitude of up to 800 mu V. Most of these 'giant' events originated in the temporo-occipital areas, with a maximum rate of about 8/min, and their occurrence as well as amplitude showed a decline by the time of normal birth. In age-matched fetal brain tissue, this decrease in the spontaneous activity transients was associated with a developmental up-regulation of the neuronal chloride extruder K+-Cl- cotransporter 2, a crucial molecule for the generation of inhibitory GABAergic Cl- currents. Our work indicates that slow endogenous activity transients in the immature human neocortex are mostly confined to the prenatal stage and appear to be terminated in parallel with the maturation of functional GABAergic inhibition.{"}",
keywords = "cortical development, DC-EEG, intracellular chloride, KCC2, preterm EEG, trace alternant, FULL-TERM NEWBORNS, NEOCORTICAL NEURONS, KCC2 EXPRESSION, PRETERM INFANTS, CALCIUM WAVES, FETAL-BRAIN, GABA, OSCILLATIONS, HIPPOCAMPUS, MATURATION, 118 Biological sciences, 311 Basic medicine",
author = "S Vanhatalo and Palva, {J. Matias} and Sture Andersson and Claudio Rivera and Juha Voipio and Kai Kaila",
year = "2005",
doi = "10.1111/j.1460-9568.2005.04459.x",
language = "English",
volume = "22",
pages = "2799--2804",
journal = "European Journal of Neuroscience",
issn = "0953-816X",
publisher = "Wiley",
number = "11",

}

TY - JOUR

T1 - Slow endogenous activity transients and developmental expression of K+-Cl- cotransporter 2 in the immature human cortex

AU - Vanhatalo, S

AU - Palva, J. Matias

AU - Andersson, Sture

AU - Rivera, Claudio

AU - Voipio, Juha

AU - Kaila, Kai

PY - 2005

Y1 - 2005

N2 - "Spontaneous transients of correlated activity are a characteristic feature of immature brain structures, where they are thought to be crucial for the establishment of precise neuronal connectivity. Studies on experimental animals have shown that this kind of early activity in cortical structures is composed of long-lasting, intermittent network events, which undergo a developmental decline that is closely paralleled by the maturation of GABAergic inhibition. In order to examine whether similar events occur in the immature human cortex, we performed direct current-coupled electroencephalography (EEG) recordings from sleeping preterm babies. We show now that much of the preterm EEG activity is confined to spontaneous, slow activity transients. These transients are characterized by a large voltage deflection that nests prominent oscillatory activity in several frequency bands covering the whole frequency spectrum of the preterm EEG (< 0.1-30 Hz). The slow voltage deflections had an amplitude of up to 800 mu V. Most of these 'giant' events originated in the temporo-occipital areas, with a maximum rate of about 8/min, and their occurrence as well as amplitude showed a decline by the time of normal birth. In age-matched fetal brain tissue, this decrease in the spontaneous activity transients was associated with a developmental up-regulation of the neuronal chloride extruder K+-Cl- cotransporter 2, a crucial molecule for the generation of inhibitory GABAergic Cl- currents. Our work indicates that slow endogenous activity transients in the immature human neocortex are mostly confined to the prenatal stage and appear to be terminated in parallel with the maturation of functional GABAergic inhibition."

AB - "Spontaneous transients of correlated activity are a characteristic feature of immature brain structures, where they are thought to be crucial for the establishment of precise neuronal connectivity. Studies on experimental animals have shown that this kind of early activity in cortical structures is composed of long-lasting, intermittent network events, which undergo a developmental decline that is closely paralleled by the maturation of GABAergic inhibition. In order to examine whether similar events occur in the immature human cortex, we performed direct current-coupled electroencephalography (EEG) recordings from sleeping preterm babies. We show now that much of the preterm EEG activity is confined to spontaneous, slow activity transients. These transients are characterized by a large voltage deflection that nests prominent oscillatory activity in several frequency bands covering the whole frequency spectrum of the preterm EEG (< 0.1-30 Hz). The slow voltage deflections had an amplitude of up to 800 mu V. Most of these 'giant' events originated in the temporo-occipital areas, with a maximum rate of about 8/min, and their occurrence as well as amplitude showed a decline by the time of normal birth. In age-matched fetal brain tissue, this decrease in the spontaneous activity transients was associated with a developmental up-regulation of the neuronal chloride extruder K+-Cl- cotransporter 2, a crucial molecule for the generation of inhibitory GABAergic Cl- currents. Our work indicates that slow endogenous activity transients in the immature human neocortex are mostly confined to the prenatal stage and appear to be terminated in parallel with the maturation of functional GABAergic inhibition."

KW - cortical development

KW - DC-EEG

KW - intracellular chloride

KW - KCC2

KW - preterm EEG

KW - trace alternant

KW - FULL-TERM NEWBORNS

KW - NEOCORTICAL NEURONS

KW - KCC2 EXPRESSION

KW - PRETERM INFANTS

KW - CALCIUM WAVES

KW - FETAL-BRAIN

KW - GABA

KW - OSCILLATIONS

KW - HIPPOCAMPUS

KW - MATURATION

KW - 118 Biological sciences

KW - 311 Basic medicine

U2 - 10.1111/j.1460-9568.2005.04459.x

DO - 10.1111/j.1460-9568.2005.04459.x

M3 - Article

VL - 22

SP - 2799

EP - 2804

JO - European Journal of Neuroscience

JF - European Journal of Neuroscience

SN - 0953-816X

IS - 11

ER -