Spatio-Design of Multi-Dimensional Prickly Zn-Doped CuO Nanoparticle for Efficient Bacterial Killing

Runrun Wu, Hongbo Zhang, Jianming Pan, Hengjia Zhu, Yue Ma, Wenguo Cui, Helder Almeida Santos, Guoqing Pan

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Zinc-doped copper oxide (Zn-CuO) is a promising material for the development of antimicrobial materials due to its safety, stability, and the high effective antibacterial activities against multidrug-resistant bacteria. The intracellular reactive oxygen species produced by Zn-CuO nanomaterials play important role in bacterial killing; however, the relationship between nanostructure and antibacterial activity has yet to be elucidated. In this study, we prepared, for the first time, Zn-CuO nanoparticles with prickly nanostructures via a green sonochemical method. The resultant prickly Zn-CuO nanoparticles exhibited strong antibacterial activity that killed 99% of bacteria within 10 min and significantly hamper bacterial growth. Prickly Zn-CuO nanoparticles showed a nano-piercing process and subsequently in situ formation of nanopores on the bacterial cell wall. The effect of nano-piercing on cell wall damage and bacterial killing was demonstrated by employing Zn-CuO nanorods with only two-sharp tips for comparison. Due to the change of the nano-piercing process from multi-dimensional (prickly) to one-dimension (rod-like), the Zn-CuO nanorods exhibited distinctly lower antibacterial activity compared to the prickly nanoparticles. This indicates the importance of nanostructures on the antibacterial activity of Zn-CuO nanoparticles, i.e., the architecture-enhanced nano-piercing for bacterial killing. Thus, prickly Zn-CuO nanoparticles are promising architecture-enhanced bacterial killing in clinical and environmental applications.
Original languageEnglish
Article number1600472
JournalAdvanced Materials Interfaces
Volume3
Issue number18
Number of pages11
ISSN2196-7350
DOIs
Publication statusPublished - 20 Sep 2016
MoE publication typeA1 Journal article-refereed

Fields of Science

  • 116 Chemical sciences
  • 317 Pharmacy
  • ENHANCED ANTIBACTERIAL ACTIVITY
  • GRAPHENE OXIDE
  • ANTIMICROBIAL ACTIVITY
  • SILVER NANOPARTICLES
  • GOLD NANOPARTICLES
  • RESISTANT BACTERIA
  • CARBON NANOTUBES
  • OXIDATIVE STRESS
  • MECHANISM
  • TOXICITY

Cite this

Wu, Runrun ; Zhang, Hongbo ; Pan, Jianming ; Zhu, Hengjia ; Ma, Yue ; Cui, Wenguo ; Almeida Santos, Helder ; Pan, Guoqing . / Spatio-Design of Multi-Dimensional Prickly Zn-Doped CuO Nanoparticle for Efficient Bacterial Killing. In: Advanced Materials Interfaces . 2016 ; Vol. 3, No. 18.
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title = "Spatio-Design of Multi-Dimensional Prickly Zn-Doped CuO Nanoparticle for Efficient Bacterial Killing",
abstract = "Zinc-doped copper oxide (Zn-CuO) is a promising material for the development of antimicrobial materials due to its safety, stability, and the high effective antibacterial activities against multidrug-resistant bacteria. The intracellular reactive oxygen species produced by Zn-CuO nanomaterials play important role in bacterial killing; however, the relationship between nanostructure and antibacterial activity has yet to be elucidated. In this study, we prepared, for the first time, Zn-CuO nanoparticles with prickly nanostructures via a green sonochemical method. The resultant prickly Zn-CuO nanoparticles exhibited strong antibacterial activity that killed 99{\%} of bacteria within 10 min and significantly hamper bacterial growth. Prickly Zn-CuO nanoparticles showed a nano-piercing process and subsequently in situ formation of nanopores on the bacterial cell wall. The effect of nano-piercing on cell wall damage and bacterial killing was demonstrated by employing Zn-CuO nanorods with only two-sharp tips for comparison. Due to the change of the nano-piercing process from multi-dimensional (prickly) to one-dimension (rod-like), the Zn-CuO nanorods exhibited distinctly lower antibacterial activity compared to the prickly nanoparticles. This indicates the importance of nanostructures on the antibacterial activity of Zn-CuO nanoparticles, i.e., the architecture-enhanced nano-piercing for bacterial killing. Thus, prickly Zn-CuO nanoparticles are promising architecture-enhanced bacterial killing in clinical and environmental applications.",
keywords = "116 Chemical sciences, 317 Pharmacy, ENHANCED ANTIBACTERIAL ACTIVITY , GRAPHENE OXIDE , ANTIMICROBIAL ACTIVITY , SILVER NANOPARTICLES , GOLD NANOPARTICLES , RESISTANT BACTERIA , CARBON NANOTUBES , OXIDATIVE STRESS , MECHANISM , TOXICITY",
author = "Runrun Wu and Hongbo Zhang and Jianming Pan and Hengjia Zhu and Yue Ma and Wenguo Cui and {Almeida Santos}, Helder and Guoqing Pan",
year = "2016",
month = "9",
day = "20",
doi = "10.1002/admi.201600472",
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Spatio-Design of Multi-Dimensional Prickly Zn-Doped CuO Nanoparticle for Efficient Bacterial Killing. / Wu, Runrun ; Zhang, Hongbo; Pan, Jianming ; Zhu, Hengjia ; Ma, Yue ; Cui, Wenguo ; Almeida Santos, Helder; Pan, Guoqing .

In: Advanced Materials Interfaces , Vol. 3, No. 18, 1600472, 20.09.2016.

Research output: Contribution to journalArticleScientificpeer-review

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T1 - Spatio-Design of Multi-Dimensional Prickly Zn-Doped CuO Nanoparticle for Efficient Bacterial Killing

AU - Wu, Runrun

AU - Zhang, Hongbo

AU - Pan, Jianming

AU - Zhu, Hengjia

AU - Ma, Yue

AU - Cui, Wenguo

AU - Almeida Santos, Helder

AU - Pan, Guoqing

PY - 2016/9/20

Y1 - 2016/9/20

N2 - Zinc-doped copper oxide (Zn-CuO) is a promising material for the development of antimicrobial materials due to its safety, stability, and the high effective antibacterial activities against multidrug-resistant bacteria. The intracellular reactive oxygen species produced by Zn-CuO nanomaterials play important role in bacterial killing; however, the relationship between nanostructure and antibacterial activity has yet to be elucidated. In this study, we prepared, for the first time, Zn-CuO nanoparticles with prickly nanostructures via a green sonochemical method. The resultant prickly Zn-CuO nanoparticles exhibited strong antibacterial activity that killed 99% of bacteria within 10 min and significantly hamper bacterial growth. Prickly Zn-CuO nanoparticles showed a nano-piercing process and subsequently in situ formation of nanopores on the bacterial cell wall. The effect of nano-piercing on cell wall damage and bacterial killing was demonstrated by employing Zn-CuO nanorods with only two-sharp tips for comparison. Due to the change of the nano-piercing process from multi-dimensional (prickly) to one-dimension (rod-like), the Zn-CuO nanorods exhibited distinctly lower antibacterial activity compared to the prickly nanoparticles. This indicates the importance of nanostructures on the antibacterial activity of Zn-CuO nanoparticles, i.e., the architecture-enhanced nano-piercing for bacterial killing. Thus, prickly Zn-CuO nanoparticles are promising architecture-enhanced bacterial killing in clinical and environmental applications.

AB - Zinc-doped copper oxide (Zn-CuO) is a promising material for the development of antimicrobial materials due to its safety, stability, and the high effective antibacterial activities against multidrug-resistant bacteria. The intracellular reactive oxygen species produced by Zn-CuO nanomaterials play important role in bacterial killing; however, the relationship between nanostructure and antibacterial activity has yet to be elucidated. In this study, we prepared, for the first time, Zn-CuO nanoparticles with prickly nanostructures via a green sonochemical method. The resultant prickly Zn-CuO nanoparticles exhibited strong antibacterial activity that killed 99% of bacteria within 10 min and significantly hamper bacterial growth. Prickly Zn-CuO nanoparticles showed a nano-piercing process and subsequently in situ formation of nanopores on the bacterial cell wall. The effect of nano-piercing on cell wall damage and bacterial killing was demonstrated by employing Zn-CuO nanorods with only two-sharp tips for comparison. Due to the change of the nano-piercing process from multi-dimensional (prickly) to one-dimension (rod-like), the Zn-CuO nanorods exhibited distinctly lower antibacterial activity compared to the prickly nanoparticles. This indicates the importance of nanostructures on the antibacterial activity of Zn-CuO nanoparticles, i.e., the architecture-enhanced nano-piercing for bacterial killing. Thus, prickly Zn-CuO nanoparticles are promising architecture-enhanced bacterial killing in clinical and environmental applications.

KW - 116 Chemical sciences

KW - 317 Pharmacy

KW - ENHANCED ANTIBACTERIAL ACTIVITY

KW - GRAPHENE OXIDE

KW - ANTIMICROBIAL ACTIVITY

KW - SILVER NANOPARTICLES

KW - GOLD NANOPARTICLES

KW - RESISTANT BACTERIA

KW - CARBON NANOTUBES

KW - OXIDATIVE STRESS

KW - MECHANISM

KW - TOXICITY

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U2 - 10.1002/admi.201600472

DO - 10.1002/admi.201600472

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JF - Advanced Materials Interfaces

SN - 2196-7350

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