Spray-drying is a very well established technology, used for converting emulsions, suspensions, dispersions, or liquids into fine, dispersible particles by the use of an atomizer into a hot drying gas medium. It is a reliable and reproducible technique for particle design and tailored production, suited for a variety of applications, including drug delivery. The oral route is by far the preferred route of administration and, among other advantages, has easy-to-follow therapeutic regimens, and therefore, the highest patient compliance. Considering the myriad of advantages of advanced fabrication methods like spray-drying over conventional particle fabrication methods, the spray-drying technique holds potential in the formulation of oral drug delivery systems with improved solubility and, thereby, oral bioavailability. In this chapter, we review the principles of spray-drying, the equipment configurations used, the parameters and variables affecting particle formulation, and the main considerations for a successful industrial scale-up. We also discuss the formulation of drugs/drug delivery systems for oral administration using spray-drying, providing examples of micro/nano-particles and pure drug particles that have demonstrated the potential of this technology to overcome the limited bioavailability of drug formulations produced by other fabrication methods.
Original languageEnglish
Title of host publicationNanotechnology for oral drug delivery : from concept to applications
EditorsJoão Pedro Martins, Hélder A. Santos
Number of pages32
Place of PublicationLondon
PublisherAcademic Press
Publication date27 Jul 2020
ISBN (Print)978-0-12-818038-9
ISBN (Electronic) 978-0-12-818039-6
Publication statusPublished - 27 Jul 2020
MoE publication typeB2 Book chapter

Fields of Science

  • 221 Nano-technology

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