Stanniocalcin Protein Expression in Female Reproductive Organs: Literature Review and Public Cancer Database Analysis

Masuma Khatun, Vijayachitra Modhukur, Terhi T. Piltonen, Juha S. Tapanainen, Andres Salumets

Research output: Contribution to journalReview Articlepeer-review

Abstract

Stanniocalcin (STC) 1 and 2 serve as antihyperglycemic polypeptide hormones with critical roles in regulating calcium and phosphate homeostasis. They additionally function as paracrine and/or autocrine factors involved in numerous physiological processes, including female reproduction. STC1 and STC2 contribute to the pathophysiology of several diseases, including female infertility- and pregnancy-associated conditions, and even tumorigenesis of reproductive organs. This comprehensive review highlights the dynamic expression patterns and potential dysregulation of STC1 and STC2, restricted to female fertility, and infertility- and pregnancy-associated diseases and conditions, such as endometriosis, polycystic ovary syndrome (PCOS), abnormal uterine bleeding, uterine polyps, and pregnancy complications, like impaired decidualization, preeclampsia, and preterm labor. Furthermore, the review elucidates the role of dysregulated STC in the progression of cancers of the reproductive system, including endometrial, cervical, and ovarian cancers. Additionally, the review evaluates the expression patterns and prognostic significance of STC in gynecological cancers by utilizing existing public datasets from The Cancer Genome Atlas to help decipher the multifaceted roles of these pleiotropic hormones in disease progression. Understanding the intricate mechanisms by which STC proteins influence all these reviewed conditions could lead to the development of targeted diagnostic and therapeutic strategies in the context of female reproductive health and oncology.

Original languageEnglish
Article numberbqae110
JournalEndocrinology (United States)
Volume165
Issue number10
Number of pages14
ISSN0013-7227
DOIs
Publication statusPublished - 13 Sept 2024
MoE publication typeA2 Review article in a scientific journal

Bibliographical note

Publisher Copyright:
© The Author(s) 2024.

Fields of Science

  • cervical cancer
  • endometrial cancer
  • endometriosis
  • ovarian cancer
  • polycystic ovary syndrome
  • stanniocalcin
  • 3121 General medicine, internal medicine and other clinical medicine

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