Statin usage and all-cause and disease-specific mortality in a nationwide study

Jari Haukka, Leo Niskanen, Timo Partonen, Jouko Lonnqvist, Jari Tiihonen

Research output: Contribution to journalArticleScientificpeer-review

Abstract

CONTEXT: The consumption of statins (HMG-CoA reductase inhibitors) in most Western countries has increased to the extent that it may affect all-cause and disease-specific mortality.

OBJECTIVE: To analyze the association of statin use with all-cause and disease-specific mortality utilizing nationwide databases in a record linkage study in Finland.

METHODS: The study population included all statin users in Finland who had purchased at least one prescription between 1997 and 2005. A control population matched for age, sex, and place of residence and without statin usage was selected. The study population consisted of 336, 618 pairs of individuals, and the mean length of follow-up was 4.4 years. All-cause mortality and mortality caused by coronary heart disease (CHD), stroke, other circulatory causes, cancer, unnatural causes, and suicide were analyzed. Persistence to treatment was calculated by varying adherence criteria between 20 and 80%.

RESULTS: We observed association between all-cause, non-CHD and CHD and treatment with statins in statin user group. For CHD mortality, we observed a relationship between the persistence to statin treatment and a decreasing CHD mortality. For each 10% increase in adherence criteria, a 5% (2-8%) decrease in CHD mortality was observed within the range of 20% (RR 0.81, 95%CI 0.32-2.02) to 80% (RR 0.54, 95%CI 0.46-0.64).

CONCLUSION: In this nationwide study, long-term use of statins is associated with the reduction in CHD mortality.

Original languageEnglish
JournalPharmacoepidemiology and Drug Safety
Volume21
Issue number1
Pages (from-to)61-69
Number of pages9
ISSN1053-8569
DOIs
Publication statusPublished - 2012
MoE publication typeA1 Journal article-refereed

Fields of Science

  • statins
  • mortality
  • pharmacoepidemiology
  • POPULATION-BASED COHORT
  • 14 RANDOMIZED-TRIALS
  • HEART-DISEASE
  • METAANALYSIS
  • CHOLESTEROL
  • CANCER
  • PEOPLE
  • RISK
  • SURVIVAL
  • EFFICACY
  • 3142 Public health care science, environmental and occupational health

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