Stem cell transplantation in autoimmune diseases

an update

Esa Jantunen, Riitta Luosujärvi

    Research output: Contribution to journalArticleScientificpeer-review

    Abstract

    Immunosuppressive or immunomodulatory treatments are often used in patients with various autoimmune diseases (AID). However, since conventional treatments are rarely curative, alternative treatment methods have been looked for. Based on animal experiments and anecdotal case reports, stem cell transplantation (SCT) has received considerable attention in the treatment of severe autoimmune diseases during the last decade. This review summarizes current experience of SCT in patients this field. Although early experience shows some promise, randomized studies are necessary to evaluate the real value of autologous SCT in various autoimmune diseases. Since autologous SCT may not be curative in patients with AID, also evaluation of allogeneic SCT is important in the future.
    Original languageEnglish
    JournalAnnals of Medicine
    Volume37
    Pages (from-to)533-541
    Number of pages9
    ISSN0785-3890
    DOIs
    Publication statusPublished - 2005
    MoE publication typeA1 Journal article-refereed

    Cite this

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    title = "Stem cell transplantation in autoimmune diseases: an update",
    abstract = "Immunosuppressive or immunomodulatory treatments are often used in patients with various autoimmune diseases (AID). However, since conventional treatments are rarely curative, alternative treatment methods have been looked for. Based on animal experiments and anecdotal case reports, stem cell transplantation (SCT) has received considerable attention in the treatment of severe autoimmune diseases during the last decade. This review summarizes current experience of SCT in patients this field. Although early experience shows some promise, randomized studies are necessary to evaluate the real value of autologous SCT in various autoimmune diseases. Since autologous SCT may not be curative in patients with AID, also evaluation of allogeneic SCT is important in the future.",
    author = "Esa Jantunen and Riitta Luosuj{\"a}rvi",
    year = "2005",
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    language = "English",
    volume = "37",
    pages = "533--541",
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    Stem cell transplantation in autoimmune diseases : an update. / Jantunen, Esa; Luosujärvi, Riitta.

    In: Annals of Medicine, Vol. 37, 2005, p. 533-541.

    Research output: Contribution to journalArticleScientificpeer-review

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    T1 - Stem cell transplantation in autoimmune diseases

    T2 - an update

    AU - Jantunen, Esa

    AU - Luosujärvi, Riitta

    PY - 2005

    Y1 - 2005

    N2 - Immunosuppressive or immunomodulatory treatments are often used in patients with various autoimmune diseases (AID). However, since conventional treatments are rarely curative, alternative treatment methods have been looked for. Based on animal experiments and anecdotal case reports, stem cell transplantation (SCT) has received considerable attention in the treatment of severe autoimmune diseases during the last decade. This review summarizes current experience of SCT in patients this field. Although early experience shows some promise, randomized studies are necessary to evaluate the real value of autologous SCT in various autoimmune diseases. Since autologous SCT may not be curative in patients with AID, also evaluation of allogeneic SCT is important in the future.

    AB - Immunosuppressive or immunomodulatory treatments are often used in patients with various autoimmune diseases (AID). However, since conventional treatments are rarely curative, alternative treatment methods have been looked for. Based on animal experiments and anecdotal case reports, stem cell transplantation (SCT) has received considerable attention in the treatment of severe autoimmune diseases during the last decade. This review summarizes current experience of SCT in patients this field. Although early experience shows some promise, randomized studies are necessary to evaluate the real value of autologous SCT in various autoimmune diseases. Since autologous SCT may not be curative in patients with AID, also evaluation of allogeneic SCT is important in the future.

    U2 - 10.1080/07853890500330250

    DO - 10.1080/07853890500330250

    M3 - Article

    VL - 37

    SP - 533

    EP - 541

    JO - Annals of Medicine

    JF - Annals of Medicine

    SN - 0785-3890

    ER -