Stereoselective Synthesis of Alfa-5-halo-2’-deoxyuridines

Tom Erik Lagerwall; Petri Heinonen; Mikko Oivanen

Stereoselective Synthesis of Alfa-5-halo-2’-deoxyuridines

Tom Erik Lagerwall, Petri Heinonen, Mikko Oivanen

Department of Chemistry

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Scientific

Abstract

Reversed stereoselectivity is observed, when 5-halouracils are used in place of uracil or thymine in gly-cosidation with 2-deoxy-D-ribose having a β/α-directing 3-O-protection. Several 5-halo-2’-deoxyuridine deriva-tives have been synthesized and the effects on the β/α-ratio are analysed.

Translated title of the contribution	Alfa-5-halo-2'-deoksiuridiinien stereoselektiivinen synteesi
Original language	English
Title of host publication	XX International Round Table on Nucleosides, Nucleotides & Nucleic Acids
Number of pages	1
Publication date	2012
Publication status	Published - 2012
MoE publication type	B3 Article in conference proceedings
Event	International Round Table - Montréal, Canada Duration: 5 Aug 2012 → 9 Aug 2012 Conference number: 20

Fields of Science

116 Chemical sciences

Cite this

@inproceedings{0f45003823d44e028242e9f6d03df6df,

title = "Stereoselective Synthesis of Alfa-5-halo-2{\textquoteright}-deoxyuridines",

abstract = "Reversed stereoselectivity is observed, when 5-halouracils are used in place of uracil or thymine in gly-cosidation with 2-deoxy-D-ribose having a β/α-directing 3-O-protection. Several 5-halo-2{\textquoteright}-deoxyuridine deriva-tives have been synthesized and the effects on the β/α-ratio are analysed.",

keywords = "116 Chemical sciences, nukleiinihappojen synteesi, stereselektiivinen synteesi",

author = "Lagerwall, {Tom Erik} and Petri Heinonen and Mikko Oivanen",

year = "2012",

language = "English",

booktitle = "XX International Round Table on Nucleosides, Nucleotides & Nucleic Acids",

note = "International Round Table ; Conference date: 05-08-2012 Through 09-08-2012",

}

TY - GEN

T1 - Stereoselective Synthesis of Alfa-5-halo-2’-deoxyuridines

AU - Lagerwall, Tom Erik

AU - Heinonen, Petri

AU - Oivanen, Mikko

N1 - Conference code: 20

PY - 2012

Y1 - 2012

N2 - Reversed stereoselectivity is observed, when 5-halouracils are used in place of uracil or thymine in gly-cosidation with 2-deoxy-D-ribose having a β/α-directing 3-O-protection. Several 5-halo-2’-deoxyuridine deriva-tives have been synthesized and the effects on the β/α-ratio are analysed.

AB - Reversed stereoselectivity is observed, when 5-halouracils are used in place of uracil or thymine in gly-cosidation with 2-deoxy-D-ribose having a β/α-directing 3-O-protection. Several 5-halo-2’-deoxyuridine deriva-tives have been synthesized and the effects on the β/α-ratio are analysed.

KW - 116 Chemical sciences

KW - nukleiinihappojen synteesi

KW - stereselektiivinen synteesi

M3 - Conference contribution

BT - XX International Round Table on Nucleosides, Nucleotides & Nucleic Acids

T2 - International Round Table

Y2 - 5 August 2012 through 9 August 2012

ER -