Stroke genetics informs drug discovery and risk prediction across ancestries

COMPASS Consortium; INVENT Consortium; Estonian Biobank; PRECISEQ Consortium; FinnGen Consortium; MEGASTROKE Consortium; SIREN Consortium; Biobank Japan; CHARGE Consortium; GIGASTROKE Consortium; Regeneron Genetics Ctr; ODYSSEY Study; SICFAIL Study; Generacion Study; SMART Study; Helsinki Stroke Project; EPIC; Aniket Mishra; Rainer Malik; Tsuyoshi Hachiya; Liisa Tomppo; Aki S. Havulinna; Marja K. Puurunen; David Weir; Jukka Putaala; Gerli Sibolt; Markus Perola; Pekka Jousilahti; Antti-Pekka Sarin; Nicolas Martinez-Majander; Wei Zhou; Sami Curtze; Sami Curtze; Marjaana Tiainen; Janne Kinnunen; Daniel Strbian

doi:10.1038/s41586-022-05165-3

Stroke genetics informs drug discovery and risk prediction across ancestries

COMPASS Consortium, INVENT Consortium, Estonian Biobank, PRECISEQ Consortium, FinnGen Consortium, MEGASTROKE Consortium, SIREN Consortium, Biobank Japan, CHARGE Consortium, GIGASTROKE Consortium, Regeneron Genetics Ctr, ODYSSEY Study, SICFAIL Study, Generacion Study, SMART Study, Helsinki Stroke Project, EPIC, Aniket Mishra, Rainer Malik, Tsuyoshi HachiyaLiisa Tomppo, Aki S. Havulinna, Marja K. Puurunen, David Weir, Jukka Putaala, Gerli Sibolt, Markus Perola, Pekka Jousilahti, Antti-Pekka Sarin, Nicolas Martinez-Majander, Wei Zhou, Sami Curtze, Sami Curtze, Marjaana Tiainen, Janne Kinnunen, Daniel Strbian

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Nature
Volume	611
Issue number	7934
Pages (from-to)	115–123
Number of pages	34
ISSN	0028-0836
DOIs	https://doi.org/10.1038/s41586-022-05165-3
Publication status	Published - 2022
MoE publication type	A1 Journal article-refereed

Bibliographical note

Daniel Strbian työryhmän jäsenenä
Correction; Early Access
DOI: 10.1038/s41586-022-05492-5
Early Access: NOV 2022

Fields of Science

GENOME-WIDE ASSOCIATION
MENDELIAN RANDOMIZATION
POLYGENIC RISK
HERITABILITY
STATISTICS
EXPRESSION
BRAIN
ATLAS
REGULARIZATION
METAANALYSIS
3112 Neurosciences

Access to Document

10.1038/s41586-022-05165-3

s41586-022-05165-3Final published version, 16.2 MBLicence: CC BY
Correction s41586-022-05492-5 (1)Final published version, 647 KBLicence: CC BY

Cite this

COMPASS Consortium, INVENT Consortium, Estonian Biobank, PRECISEQ Consortium, FinnGen Consortium, MEGASTROKE Consortium, SIREN Consortium, Biobank Japan, CHARGE Consortium, GIGASTROKE Consortium, Regeneron Genetics Ctr, ODYSSEY Study, SICFAIL Study, Generacion Study, SMART Study, Helsinki Stroke Project, EPIC, Mishra, A., Malik, R., ... Strbian, D. (2022). Stroke genetics informs drug discovery and risk prediction across ancestries. Nature, 611(7934), 115–123 . https://doi.org/10.1038/s41586-022-05165-3

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author = "{COMPASS Consortium} and {INVENT Consortium} and {Estonian Biobank} and {PRECISEQ Consortium} and {FinnGen Consortium} and {MEGASTROKE Consortium} and {SIREN Consortium} and {Biobank Japan} and {CHARGE Consortium} and {GIGASTROKE Consortium} and {Regeneron Genetics Ctr} and {ODYSSEY Study} and {SICFAIL Study} and {Generacion Study} and {SMART Study} and {Helsinki Stroke Project} and EPIC and Aniket Mishra and Rainer Malik and Tsuyoshi Hachiya and Tuuli Jurgenson and Shinichi Namba and Posner, {Daniel C.} and Kamanu, {Frederick K.} and Masaru Koido and {Le Grand}, Quentin and Mingyang Shi and Yunye He and Georgakis, {Marios K.} and Ilana Caro and Kristi Krebs and Yi-Ching Liaw and Vaura, {Felix C.} and Kuang Lin and Winsvold, {Bendik Slagsvold} and Vinodh Srinivasasainagendra and Livia Parodi and Hee-Joon Bae and Ganesh Chauhan and Chong, {Michael R.} and Liisa Tomppo and Rufus Akinyemi and Roshchupkin, {Gennady V.} and Naomi Habib and Jee, {Yon Ho} and Thomassen, {Jesper Qvist} and Vida Abedi and Jara Carcel-Marquez and Marianne Nygaard and Leonard, {Hampton L.} and Chaojie Yang and Ekaterina Yonova-Doing and Knol, {Maria J.} and Havulinna, {Aki S.} and Puurunen, {Marja K.} and David Weir and Jukka Putaala and Gerli Sibolt and Markus Perola and Pekka Jousilahti and Antti-Pekka Sarin and Nicolas Martinez-Majander and Wei Zhou and Sami Curtze and Sami Curtze and Marjaana Tiainen and Janne Kinnunen and Daniel Strbian",

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doi = "10.1038/s41586-022-05165-3",

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COMPASS Consortium, INVENT Consortium, Estonian Biobank, PRECISEQ Consortium, FinnGen Consortium, MEGASTROKE Consortium, SIREN Consortium, Biobank Japan, CHARGE Consortium, GIGASTROKE Consortium, Regeneron Genetics Ctr, ODYSSEY Study, SICFAIL Study, Generacion Study, SMART Study, Helsinki Stroke Project, EPIC, Mishra, A, Malik, R, Hachiya, T, Tomppo, L , Havulinna, AS, Puurunen, MK, Weir, D, Putaala, J, Sibolt, G, Perola, M, Jousilahti, P, Sarin, A-P, Martinez-Majander, N, Zhou, W, Curtze, S, Curtze, S, Tiainen, M, Kinnunen, J & Strbian, D 2022, 'Stroke genetics informs drug discovery and risk prediction across ancestries', Nature, vol. 611, no. 7934, pp. 115–123 . https://doi.org/10.1038/s41586-022-05165-3

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T1 - Stroke genetics informs drug discovery and risk prediction across ancestries

AU - COMPASS Consortium

AU - INVENT Consortium

AU - Estonian Biobank

AU - PRECISEQ Consortium

AU - FinnGen Consortium

AU - MEGASTROKE Consortium

AU - SIREN Consortium

AU - Biobank Japan

AU - CHARGE Consortium

AU - GIGASTROKE Consortium

AU - Regeneron Genetics Ctr

AU - ODYSSEY Study

AU - SICFAIL Study

AU - Generacion Study

AU - SMART Study

AU - Helsinki Stroke Project

AU - EPIC

AU - Mishra, Aniket

AU - Malik, Rainer

AU - Hachiya, Tsuyoshi

AU - Jurgenson, Tuuli

AU - Namba, Shinichi

AU - Posner, Daniel C.

AU - Kamanu, Frederick K.

AU - Koido, Masaru

AU - Le Grand, Quentin

AU - Shi, Mingyang

AU - He, Yunye

AU - Georgakis, Marios K.

AU - Caro, Ilana

AU - Krebs, Kristi

AU - Liaw, Yi-Ching

AU - Vaura, Felix C.

AU - Lin, Kuang

AU - Winsvold, Bendik Slagsvold

AU - Srinivasasainagendra, Vinodh

AU - Parodi, Livia

AU - Bae, Hee-Joon

AU - Chauhan, Ganesh

AU - Chong, Michael R.

AU - Tomppo, Liisa

AU - Akinyemi, Rufus

AU - Roshchupkin, Gennady V.

AU - Habib, Naomi

AU - Jee, Yon Ho

AU - Thomassen, Jesper Qvist

AU - Abedi, Vida

AU - Carcel-Marquez, Jara

AU - Nygaard, Marianne

AU - Leonard, Hampton L.

AU - Yang, Chaojie

AU - Yonova-Doing, Ekaterina

AU - Knol, Maria J.

AU - Havulinna, Aki S.

AU - Puurunen, Marja K.

AU - Weir, David

AU - Putaala, Jukka

AU - Sibolt, Gerli

AU - Perola, Markus

AU - Jousilahti, Pekka

AU - Sarin, Antti-Pekka

AU - Martinez-Majander, Nicolas

AU - Zhou, Wei

AU - Curtze, Sami

AU - Tiainen, Marjaana

AU - Kinnunen, Janne

AU - Strbian, Daniel

N1 - Daniel Strbian työryhmän jäsenenä Correction; Early Access DOI: 10.1038/s41586-022-05492-5 Early Access: NOV 2022

PY - 2022

Y1 - 2022

KW - GENOME-WIDE ASSOCIATION

KW - MENDELIAN RANDOMIZATION

KW - POLYGENIC RISK

KW - HERITABILITY

KW - STATISTICS

KW - EXPRESSION

KW - BRAIN

KW - ATLAS

KW - REGULARIZATION

KW - METAANALYSIS

KW - 3112 Neurosciences

U2 - 10.1038/s41586-022-05165-3

DO - 10.1038/s41586-022-05165-3

M3 - Article

VL - 611

SP - 115

EP - 123

JO - Nature

JF - Nature

SN - 0028-0836

IS - 7934

ER -