Structure, assembly and inhibition of the Toxoplasma gondii respiratory chain supercomplex

Andrew E. MacLean; Shikha Shikha; Mariana Ferreira Silva; Max J. Gramelspacher; Aaron Nilsen; Katherine M. Liebman; Sovitj Pou; Rolf W. Winter; Amit Meir; Michael K. Riscoe; J. Stone Doggett; Lilach Sheiner; Alexander Muhleip

doi:10.1038/s41594-025-01531-7

Structure, assembly and inhibition of the Toxoplasma gondii respiratory chain supercomplex

Andrew E. MacLean
, Shikha Shikha
, Mariana Ferreira Silva
, Max J. Gramelspacher
, Aaron Nilsen
, Katherine M. Liebman
, Sovitj Pou
, Rolf W. Winter
, Amit Meir
, Michael K. Riscoe
, J. Stone Doggett
, Lilach Sheiner
, Alexander Muhleip

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Nature Structural and Molecular Biology
Volume	32
Issue number	8
Pages (from-to)	1424–1433
Number of pages	10
ISSN	1545-9993
DOIs	https://doi.org/10.1038/s41594-025-01531-7
Publication status	Published - 19 May 2025
MoE publication type	A1 Journal article-refereed

Bibliographical note

Correction: 10.1038/s41594-026-01824-5

Fields of Science

Cytochrome-c
Hydrophobicity scale
Atovaquone-binding
Complex
Visualization
Mutations
Proteins
System
Domain
Site
1182 Biochemistry, cell and molecular biology

Access to Document

10.1038/s41594-025-01531-7Licence: CC BY

s41594-025-01531-7Final published version, 26.9 MBLicence: CC BY

Cite this

MacLean, A. E., Shikha, S., Ferreira Silva, M., Gramelspacher, M. J., Nilsen, A., Liebman, K. M., Pou, S., Winter, R. W., Meir, A., Riscoe, M. K., Doggett, J. S., Sheiner, L., & Muhleip, A. (2025). Structure, assembly and inhibition of the Toxoplasma gondii respiratory chain supercomplex. Nature Structural and Molecular Biology, 32(8), 1424–1433. https://doi.org/10.1038/s41594-025-01531-7

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title = "Structure, assembly and inhibition of the Toxoplasma gondii respiratory chain supercomplex",

keywords = "Cytochrome-c, Hydrophobicity scale, Atovaquone-binding, Complex, Visualization, Mutations, Proteins, System, Domain, Site, 1182 Biochemistry, cell and molecular biology",

author = "MacLean, \{Andrew E.\} and Shikha Shikha and \{Ferreira Silva\}, Mariana and Gramelspacher, \{Max J.\} and Aaron Nilsen and Liebman, \{Katherine M.\} and Sovitj Pou and Winter, \{Rolf W.\} and Amit Meir and Riscoe, \{Michael K.\} and Doggett, \{J. Stone\} and Lilach Sheiner and Alexander Muhleip",

note = "Correction: 10.1038/s41594-026-01824-5",

year = "2025",

month = may,

day = "19",

doi = "10.1038/s41594-025-01531-7",

language = "English",

volume = "32",

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MacLean, AE, Shikha, S, Ferreira Silva, M, Gramelspacher, MJ, Nilsen, A, Liebman, KM, Pou, S, Winter, RW, Meir, A, Riscoe, MK, Doggett, JS, Sheiner, L & Muhleip, A 2025, 'Structure, assembly and inhibition of the Toxoplasma gondii respiratory chain supercomplex', Nature Structural and Molecular Biology, vol. 32, no. 8, pp. 1424–1433. https://doi.org/10.1038/s41594-025-01531-7

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T1 - Structure, assembly and inhibition of the Toxoplasma gondii respiratory chain supercomplex

AU - MacLean, Andrew E.

AU - Shikha, Shikha

AU - Ferreira Silva, Mariana

AU - Gramelspacher, Max J.

AU - Nilsen, Aaron

AU - Liebman, Katherine M.

AU - Pou, Sovitj

AU - Winter, Rolf W.

AU - Meir, Amit

AU - Riscoe, Michael K.

AU - Doggett, J. Stone

AU - Sheiner, Lilach

AU - Muhleip, Alexander

N1 - Correction: 10.1038/s41594-026-01824-5

PY - 2025/5/19

Y1 - 2025/5/19

KW - Cytochrome-c

KW - Hydrophobicity scale

KW - Atovaquone-binding

KW - Complex

KW - Visualization

KW - Mutations

KW - Proteins

KW - System

KW - Domain

KW - Site

KW - 1182 Biochemistry, cell and molecular biology

U2 - 10.1038/s41594-025-01531-7

DO - 10.1038/s41594-025-01531-7

M3 - Article

C2 - 40389671

SN - 1545-9993

VL - 32

SP - 1424

EP - 1433

JO - Nature Structural and Molecular Biology

JF - Nature Structural and Molecular Biology

IS - 8

ER -