SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease

Philipp Gut; Sanna Matilainen; Jesse G. Meyer; Pieti Pallijeff; Joy Richard; Christopher J. Carroll; Liliya Euro; Christopher B. Jackson; Pirjo Isohanni; Berge A. Minassian; Reem A. Alkhater; Elsebet Ostergaard; Gabriele Civiletto; Alice Parisi; Jonathan Thevenet; Matthew J. Rardin; Wenjuan He; Yuya Nishida; John C. Newman; Xiaojing Liu; Stefan Christen; Sofia Moco; Jason W. Locasale; Birgit Schilling; Anu Suomalainen; Eric Verdin

doi:10.1038/s41467-020-19743-4

SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease

Philipp Gut, Sanna Matilainen, Jesse G. Meyer, Pieti Pallijeff, Joy Richard, Christopher J. Carroll, Liliya Euro, Christopher B. Jackson, Pirjo Isohanni, Berge A. Minassian, Reem A. Alkhater, Elsebet Ostergaard, Gabriele Civiletto, Alice Parisi, Jonathan Thevenet, Matthew J. Rardin, Wenjuan He, Yuya Nishida, John C. Newman, Xiaojing LiuStefan Christen, Sofia Moco, Jason W. Locasale, Birgit Schilling, Anu Suomalainen, Eric Verdin

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Article number	5927
Journal	Nature Communications
Volume	11
Issue number	1
Number of pages	14
ISSN	2041-1723
DOIs	https://doi.org/10.1038/s41467-020-19743-4
Publication status	Published - 23 Nov 2020
MoE publication type	A1 Journal article-refereed

Fields of Science

HIGH-RESOLUTION METABOLOMICS
DATA-INDEPENDENT ACQUISITION
QUANTITATIVE PROTEOMICS
ACETYLATION
ENCEPHALOMYOPATHY
DEFICIENCY
ACYLATION
SIRT5
METABOLISM
DESUCCINYLATION
3111 Biomedicine

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Cite this

Gut, P., Matilainen, S., Meyer, J. G., Pallijeff, P., Richard, J., Carroll, C. J., Euro, L., Jackson, C. B., Isohanni, P., Minassian, B. A., Alkhater, R. A., Ostergaard, E., Civiletto, G., Parisi, A., Thevenet, J., Rardin, M. J., He, W., Nishida, Y., Newman, J. C., ... Verdin, E. (2020). SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease. Nature Communications, 11(1), Article 5927. https://doi.org/10.1038/s41467-020-19743-4

@article{bec7d328b4424c758415885a3ad6844e,

title = "SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease",

keywords = "HIGH-RESOLUTION METABOLOMICS, DATA-INDEPENDENT ACQUISITION, QUANTITATIVE PROTEOMICS, ACETYLATION, ENCEPHALOMYOPATHY, DEFICIENCY, ACYLATION, SIRT5, METABOLISM, DESUCCINYLATION, 3111 Biomedicine",

author = "Philipp Gut and Sanna Matilainen and Meyer, \{Jesse G.\} and Pieti Pallijeff and Joy Richard and Carroll, \{Christopher J.\} and Liliya Euro and Jackson, \{Christopher B.\} and Pirjo Isohanni and Minassian, \{Berge A.\} and Alkhater, \{Reem A.\} and Elsebet Ostergaard and Gabriele Civiletto and Alice Parisi and Jonathan Thevenet and Rardin, \{Matthew J.\} and Wenjuan He and Yuya Nishida and Newman, \{John C.\} and Xiaojing Liu and Stefan Christen and Sofia Moco and Locasale, \{Jason W.\} and Birgit Schilling and Anu Suomalainen and Eric Verdin",

year = "2020",

month = nov,

day = "23",

doi = "10.1038/s41467-020-19743-4",

language = "English",

volume = "11",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Publishing Group",

number = "1",

}

Gut, P, Matilainen, S, Meyer, JG, Pallijeff, P, Richard, J, Carroll, CJ, Euro, L , Jackson, CB , Isohanni, P, Minassian, BA, Alkhater, RA, Ostergaard, E, Civiletto, G, Parisi, A, Thevenet, J, Rardin, MJ, He, W, Nishida, Y, Newman, JC, Liu, X, Christen, S, Moco, S, Locasale, JW, Schilling, B, Suomalainen, A & Verdin, E 2020, 'SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease', Nature Communications, vol. 11, no. 1, 5927. https://doi.org/10.1038/s41467-020-19743-4

TY - JOUR

T1 - SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease

AU - Gut, Philipp

AU - Matilainen, Sanna

AU - Meyer, Jesse G.

AU - Pallijeff, Pieti

AU - Richard, Joy

AU - Carroll, Christopher J.

AU - Euro, Liliya

AU - Jackson, Christopher B.

AU - Isohanni, Pirjo

AU - Minassian, Berge A.

AU - Alkhater, Reem A.

AU - Ostergaard, Elsebet

AU - Civiletto, Gabriele

AU - Parisi, Alice

AU - Thevenet, Jonathan

AU - Rardin, Matthew J.

AU - He, Wenjuan

AU - Nishida, Yuya

AU - Newman, John C.

AU - Liu, Xiaojing

AU - Christen, Stefan

AU - Moco, Sofia

AU - Locasale, Jason W.

AU - Schilling, Birgit

AU - Suomalainen, Anu

AU - Verdin, Eric

PY - 2020/11/23

Y1 - 2020/11/23

KW - HIGH-RESOLUTION METABOLOMICS

KW - DATA-INDEPENDENT ACQUISITION

KW - QUANTITATIVE PROTEOMICS

KW - ACETYLATION

KW - ENCEPHALOMYOPATHY

KW - DEFICIENCY

KW - ACYLATION

KW - SIRT5

KW - METABOLISM

KW - DESUCCINYLATION

KW - 3111 Biomedicine

U2 - 10.1038/s41467-020-19743-4

DO - 10.1038/s41467-020-19743-4

M3 - Article

SN - 2041-1723

VL - 11

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 5927

ER -