Surface Modification of Acetaminophen Particles by Atomic Layer Deposition

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Organic solid pharmaceutical powders are used for the preparation of various drug dosage forms. Primary particles in powder form undergo several processing steps first in pharmaceutical formulations followed by pharmaceutical manufacturing to final dosage form of a drug. These unit operations involve both handling of powders in aqueous or solvent solutions and drying. There will be a probable rise for a demand for the different unit operations in the requirements of protecting the active pharmaceutical ingredient or challenges in powder handling. Besides pharmaceutical manufacturing, there are many biological interfaces where control of surface characteristics of pharmaceutical powders can improve the therapeutic response and bioavailability. In this work, we have modified acetaminophen particles with atomic layer deposition (ALD) by conformal nanometer scale coatings in a one-step coating process. According to the results, ALD comprising common chemistries for Al2O3, TiO2 and ZnO is shown to be a promising coating method for solid pharmaceutical powders. Acetaminophen does not undergo degradation during the ALD coating and maintains its stable polymorphic structure. The nanometer scale ALD coating can sustain the drug release. ALD oxide coated acetaminophen particles show different cytocompatibility assessed in in vitro intestinal Caco-2 cells.
Original languageEnglish
JournalInternational Journal of Pharmaceutics
Volume525
Issue number1
Pages (from-to)160–174
Number of pages15
ISSN0378-5173
DOIs
Publication statusPublished - 15 Jun 2017
MoE publication typeA1 Journal article-refereed

Fields of Science

  • 116 Chemical sciences
  • 317 Pharmacy
  • Atomic layer deposition
  • Acetaminophen
  • Drug release
  • Cytocombatibility
  • Drug delivery system
  • SOLID-STATE CHARACTERIZATION
  • FLUIDIZED-BED REACTOR
  • TITANIUM ISOPROPOXIDE
  • DRUG-DELIVERY
  • PHYSICAL STABILITY
  • AL2O3 FILMS
  • PARACETAMOL
  • GROWTH
  • NANOPARTICLES
  • POLYMORPHS

Cite this

@article{ca2fb99d099848fdaa06514e327e02bc,
title = "Surface Modification of Acetaminophen Particles by Atomic Layer Deposition",
abstract = "Organic solid pharmaceutical powders are used for the preparation of various drug dosage forms. Primary particles in powder form undergo several processing steps first in pharmaceutical formulations followed by pharmaceutical manufacturing to final dosage form of a drug. These unit operations involve both handling of powders in aqueous or solvent solutions and drying. There will be a probable rise for a demand for the different unit operations in the requirements of protecting the active pharmaceutical ingredient or challenges in powder handling. Besides pharmaceutical manufacturing, there are many biological interfaces where control of surface characteristics of pharmaceutical powders can improve the therapeutic response and bioavailability. In this work, we have modified acetaminophen particles with atomic layer deposition (ALD) by conformal nanometer scale coatings in a one-step coating process. According to the results, ALD comprising common chemistries for Al2O3, TiO2 and ZnO is shown to be a promising coating method for solid pharmaceutical powders. Acetaminophen does not undergo degradation during the ALD coating and maintains its stable polymorphic structure. The nanometer scale ALD coating can sustain the drug release. ALD oxide coated acetaminophen particles show different cytocompatibility assessed in in vitro intestinal Caco-2 cells.",
keywords = "116 Chemical sciences, 317 Pharmacy, Atomic layer deposition , Acetaminophen , Drug release , Cytocombatibility , Drug delivery system , SOLID-STATE CHARACTERIZATION , FLUIDIZED-BED REACTOR , TITANIUM ISOPROPOXIDE , DRUG-DELIVERY , PHYSICAL STABILITY , AL2O3 FILMS , PARACETAMOL , GROWTH , NANOPARTICLES , POLYMORPHS",
author = "K{\"a}{\"a}ri{\"a}inen, {Tommi Olavi} and Kemell, {Marianna Leena} and Vehkam{\"a}ki, {Marko Juhani} and Marja-Leena K{\"a}{\"a}ri{\"a}inen and Alexandra Correia and {Almeida Santos}, Helder and {Marques dos Santos Bimbo}, {Luis Maria} and Hirvonen, {Jouni Tapio} and Pekka Hoppu and George, {Steven M.} and Cameron, {David C.} and Ritala, {Mikko Kalervo} and Leskel{\"a}, {Markku Antero}",
year = "2017",
month = "6",
day = "15",
doi = "10.1016/j.ijpharm.2017.04.031",
language = "English",
volume = "525",
pages = "160–174",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier Scientific Publ. Co",
number = "1",

}

Surface Modification of Acetaminophen Particles by Atomic Layer Deposition. / Kääriäinen, Tommi Olavi; Kemell, Marianna Leena; Vehkamäki, Marko Juhani; Kääriäinen, Marja-Leena; Correia, Alexandra ; Almeida Santos, Helder; Marques dos Santos Bimbo, Luis Maria; Hirvonen, Jouni Tapio; Hoppu, Pekka; George, Steven M. ; Cameron, David C. ; Ritala, Mikko Kalervo; Leskelä, Markku Antero.

In: International Journal of Pharmaceutics, Vol. 525, No. 1, 15.06.2017, p. 160–174.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Surface Modification of Acetaminophen Particles by Atomic Layer Deposition

AU - Kääriäinen, Tommi Olavi

AU - Kemell, Marianna Leena

AU - Vehkamäki, Marko Juhani

AU - Kääriäinen, Marja-Leena

AU - Correia, Alexandra

AU - Almeida Santos, Helder

AU - Marques dos Santos Bimbo, Luis Maria

AU - Hirvonen, Jouni Tapio

AU - Hoppu, Pekka

AU - George, Steven M.

AU - Cameron, David C.

AU - Ritala, Mikko Kalervo

AU - Leskelä, Markku Antero

PY - 2017/6/15

Y1 - 2017/6/15

N2 - Organic solid pharmaceutical powders are used for the preparation of various drug dosage forms. Primary particles in powder form undergo several processing steps first in pharmaceutical formulations followed by pharmaceutical manufacturing to final dosage form of a drug. These unit operations involve both handling of powders in aqueous or solvent solutions and drying. There will be a probable rise for a demand for the different unit operations in the requirements of protecting the active pharmaceutical ingredient or challenges in powder handling. Besides pharmaceutical manufacturing, there are many biological interfaces where control of surface characteristics of pharmaceutical powders can improve the therapeutic response and bioavailability. In this work, we have modified acetaminophen particles with atomic layer deposition (ALD) by conformal nanometer scale coatings in a one-step coating process. According to the results, ALD comprising common chemistries for Al2O3, TiO2 and ZnO is shown to be a promising coating method for solid pharmaceutical powders. Acetaminophen does not undergo degradation during the ALD coating and maintains its stable polymorphic structure. The nanometer scale ALD coating can sustain the drug release. ALD oxide coated acetaminophen particles show different cytocompatibility assessed in in vitro intestinal Caco-2 cells.

AB - Organic solid pharmaceutical powders are used for the preparation of various drug dosage forms. Primary particles in powder form undergo several processing steps first in pharmaceutical formulations followed by pharmaceutical manufacturing to final dosage form of a drug. These unit operations involve both handling of powders in aqueous or solvent solutions and drying. There will be a probable rise for a demand for the different unit operations in the requirements of protecting the active pharmaceutical ingredient or challenges in powder handling. Besides pharmaceutical manufacturing, there are many biological interfaces where control of surface characteristics of pharmaceutical powders can improve the therapeutic response and bioavailability. In this work, we have modified acetaminophen particles with atomic layer deposition (ALD) by conformal nanometer scale coatings in a one-step coating process. According to the results, ALD comprising common chemistries for Al2O3, TiO2 and ZnO is shown to be a promising coating method for solid pharmaceutical powders. Acetaminophen does not undergo degradation during the ALD coating and maintains its stable polymorphic structure. The nanometer scale ALD coating can sustain the drug release. ALD oxide coated acetaminophen particles show different cytocompatibility assessed in in vitro intestinal Caco-2 cells.

KW - 116 Chemical sciences

KW - 317 Pharmacy

KW - Atomic layer deposition

KW - Acetaminophen

KW - Drug release

KW - Cytocombatibility

KW - Drug delivery system

KW - SOLID-STATE CHARACTERIZATION

KW - FLUIDIZED-BED REACTOR

KW - TITANIUM ISOPROPOXIDE

KW - DRUG-DELIVERY

KW - PHYSICAL STABILITY

KW - AL2O3 FILMS

KW - PARACETAMOL

KW - GROWTH

KW - NANOPARTICLES

KW - POLYMORPHS

UR - https://www.journals.elsevier.com/international-journal-of-pharmaceutics

U2 - 10.1016/j.ijpharm.2017.04.031

DO - 10.1016/j.ijpharm.2017.04.031

M3 - Article

VL - 525

SP - 160

EP - 174

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1

ER -