Surveillance of European Domestic Pig Populations Identifies an Emerging Reservoir of Potentially Zoonotic Swine Influenza A Viruses

Dinah Henritzi, Philipp Peter Petric, Nicola Sarah Lewis, Annika Graaf, Alberto Pessia, Elke Starick, Angele Breithaupt, Guenter Strebelow, Christine Luttermann, Larissa Mareike Kristin Parker, Charlotte Schroeder, Baerbel Hammerschmidt, Georg Herrler, Elisabeth Grosse Beilage, Daniel Stadlbauer, Viviana Simon, Florian Krammer, Silke Wacheck, Stefan Pesch, Martin SchwemmleMartin Beer, Timm Clemens Harder

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Summary Swine influenza A viruses (swIAVs) can play a crucial role in the generation of new human pandemic viruses. In this study, in-depth passive surveillance comprising nearly 2,500 European swine holdings and more than 18,000 individual samples identified a year-round presence of up to four major swIAV lineages on more than 50% of farms surveilled. Phylogenetic analyses show that intensive reassortment with human pandemic A(H1N1)/2009 (H1pdm) virus produced an expanding and novel repertoire of at least 31 distinct swIAV genotypes and 12 distinct hemagglutinin/neuraminidase combinations with largely unknown consequences for virulence and host tropism. Several viral isolates were resistant to the human antiviral MxA protein, a prerequisite for zoonotic transmission and stable introduction into human populations. A pronounced antigenic variation was noted in swIAV, and several H1pdm lineages antigenically distinct from current seasonal human H1pdm co-circulate in swine. Thus, European swine populations represent reservoirs for emerging IAV strains with zoonotic and, possibly, pre-pandemic potential.
Original languageEnglish
JournalCell Host & Microbe
Volume28
Issue number4
Pages (from-to)614-627
Number of pages20
ISSN1931-3128
DOIs
Publication statusPublished - 7 Oct 2020
MoE publication typeA1 Journal article-refereed

Fields of Science

  • EURASIAN AVIAN-LIKE
  • AGRICULTURAL FAIRS
  • GENETIC EVOLUTION
  • HUMAN INFECTION
  • H3N2 VIRUSES
  • HEMAGGLUTININ
  • REASSORTMENT
  • EPIDEMIOLOGY
  • ANTIBODIES
  • MICHIGAN
  • 112 Statistics and probability

Cite this