Survival of nisin activity in intestinal environment

Research output: Contribution to journalArticleScientificpeer-review

Abstract

The sensitivity of nisin to proteolytical breakdown in intestinal environment was studied in an ex vivo model using jejunal chyme from fistulated dogs. Sixty six percentage of the added nisin retained induction activity after 30 min incubation in jejunal chyme, indicating that nisin has potential to be used as an inducing agent in in situ delivery systems of bioactive peptides and proteins by genetically modified bacteria in the intestine.
Original languageEnglish
JournalBiotechnology Letters
Volume31
Issue number8
Pages (from-to)1229-1232
Number of pages4
ISSN0141-5492
DOIs
Publication statusPublished - 2009
MoE publication typeA1 Journal article-refereed

Fields of Science

  • Chyme
  • Intestine
  • Nisin
  • Shelf life
  • LACTOCOCCUS-LACTIS
  • 118 Biological sciences

Cite this

@article{4154705cfe4f4ec1ae381d5f2314970b,
title = "Survival of nisin activity in intestinal environment",
abstract = "The sensitivity of nisin to proteolytical breakdown in intestinal environment was studied in an ex vivo model using jejunal chyme from fistulated dogs. Sixty six percentage of the added nisin retained induction activity after 30 min incubation in jejunal chyme, indicating that nisin has potential to be used as an inducing agent in in situ delivery systems of bioactive peptides and proteins by genetically modified bacteria in the intestine.",
keywords = "Chyme, Intestine, Nisin, Shelf life, LACTOCOCCUS-LACTIS, 118 Biological sciences",
author = "J. Reunanen and Saris, {P. E. J.}",
year = "2009",
doi = "10.1007/s10529-009-9995-3",
language = "English",
volume = "31",
pages = "1229--1232",
journal = "Biotechnology Letters",
issn = "0141-5492",
publisher = "SPRINGER NEW YORK LLC",
number = "8",

}

Survival of nisin activity in intestinal environment. / Reunanen, J.; Saris, P. E. J.

In: Biotechnology Letters, Vol. 31, No. 8, 2009, p. 1229-1232.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Survival of nisin activity in intestinal environment

AU - Reunanen, J.

AU - Saris, P. E. J.

PY - 2009

Y1 - 2009

N2 - The sensitivity of nisin to proteolytical breakdown in intestinal environment was studied in an ex vivo model using jejunal chyme from fistulated dogs. Sixty six percentage of the added nisin retained induction activity after 30 min incubation in jejunal chyme, indicating that nisin has potential to be used as an inducing agent in in situ delivery systems of bioactive peptides and proteins by genetically modified bacteria in the intestine.

AB - The sensitivity of nisin to proteolytical breakdown in intestinal environment was studied in an ex vivo model using jejunal chyme from fistulated dogs. Sixty six percentage of the added nisin retained induction activity after 30 min incubation in jejunal chyme, indicating that nisin has potential to be used as an inducing agent in in situ delivery systems of bioactive peptides and proteins by genetically modified bacteria in the intestine.

KW - Chyme

KW - Intestine

KW - Nisin

KW - Shelf life

KW - LACTOCOCCUS-LACTIS

KW - 118 Biological sciences

U2 - 10.1007/s10529-009-9995-3

DO - 10.1007/s10529-009-9995-3

M3 - Article

VL - 31

SP - 1229

EP - 1232

JO - Biotechnology Letters

JF - Biotechnology Letters

SN - 0141-5492

IS - 8

ER -