Synthesis, in vitro and in vivo evaluation of 1,3,5-triazines as cannabinoid CB2 receptor agonists

Sari Yrjölä, Mirkka Sarparanta, Anu J. Airaksinen, Maria Hytti, Anu Kauppinen, Sanna Pasonen-Seppanen, Barbara Adinolfi, Paola Nieri, Clementina Manera, Outi Keinanen, Antti Poso, Tapio J. Nevalainen, Teija Parkkari

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalEuropean Journal of Pharmaceutical Sciences
Volume67
Pages (from-to)85-96
Number of pages12
ISSN0928-0987
DOIs
Publication statusPublished - 25 Jan 2015
MoE publication typeA1 Journal article-refereed

Fields of Science

  • Cannabinoid receptor
  • CB2R agonists
  • Triazines
  • Radioligand
  • ENDOCANNABINOID SYSTEM
  • TYPE-2 RECEPTOR
  • PET TRACER
  • APOPTOSIS
  • LIGANDS
  • CELLS
  • MELANOMA
  • LEUKEMIA
  • TARGETS
  • 317 Pharmacy
  • 116 Chemical sciences

Cite this

Yrjölä, Sari ; Sarparanta, Mirkka ; Airaksinen, Anu J. ; Hytti, Maria ; Kauppinen, Anu ; Pasonen-Seppanen, Sanna ; Adinolfi, Barbara ; Nieri, Paola ; Manera, Clementina ; Keinanen, Outi ; Poso, Antti ; Nevalainen, Tapio J. ; Parkkari, Teija. / Synthesis, in vitro and in vivo evaluation of 1,3,5-triazines as cannabinoid CB2 receptor agonists. In: European Journal of Pharmaceutical Sciences. 2015 ; Vol. 67. pp. 85-96.
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title = "Synthesis, in vitro and in vivo evaluation of 1,3,5-triazines as cannabinoid CB2 receptor agonists",
keywords = "Cannabinoid receptor, CB2R agonists, Triazines, Radioligand, ENDOCANNABINOID SYSTEM, TYPE-2 RECEPTOR, PET TRACER, APOPTOSIS, LIGANDS, CELLS, MELANOMA, LEUKEMIA, TARGETS, 317 Pharmacy, 116 Chemical sciences",
author = "Sari Yrj{\"o}l{\"a} and Mirkka Sarparanta and Airaksinen, {Anu J.} and Maria Hytti and Anu Kauppinen and Sanna Pasonen-Seppanen and Barbara Adinolfi and Paola Nieri and Clementina Manera and Outi Keinanen and Antti Poso and Nevalainen, {Tapio J.} and Teija Parkkari",
year = "2015",
month = "1",
day = "25",
doi = "10.1016/j.ejps.2014.11.003",
language = "English",
volume = "67",
pages = "85--96",
journal = "European Journal of Pharmaceutical Sciences",
issn = "0928-0987",
publisher = "Elsevier Scientific Publ. Co",

}

Yrjölä, S, Sarparanta, M, Airaksinen, AJ, Hytti, M, Kauppinen, A, Pasonen-Seppanen, S, Adinolfi, B, Nieri, P, Manera, C, Keinanen, O, Poso, A, Nevalainen, TJ & Parkkari, T 2015, 'Synthesis, in vitro and in vivo evaluation of 1,3,5-triazines as cannabinoid CB2 receptor agonists' European Journal of Pharmaceutical Sciences, vol. 67, pp. 85-96. https://doi.org/10.1016/j.ejps.2014.11.003

Synthesis, in vitro and in vivo evaluation of 1,3,5-triazines as cannabinoid CB2 receptor agonists. / Yrjölä, Sari; Sarparanta, Mirkka; Airaksinen, Anu J.; Hytti, Maria; Kauppinen, Anu; Pasonen-Seppanen, Sanna; Adinolfi, Barbara; Nieri, Paola; Manera, Clementina; Keinanen, Outi; Poso, Antti; Nevalainen, Tapio J.; Parkkari, Teija.

In: European Journal of Pharmaceutical Sciences, Vol. 67, 25.01.2015, p. 85-96.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Synthesis, in vitro and in vivo evaluation of 1,3,5-triazines as cannabinoid CB2 receptor agonists

AU - Yrjölä, Sari

AU - Sarparanta, Mirkka

AU - Airaksinen, Anu J.

AU - Hytti, Maria

AU - Kauppinen, Anu

AU - Pasonen-Seppanen, Sanna

AU - Adinolfi, Barbara

AU - Nieri, Paola

AU - Manera, Clementina

AU - Keinanen, Outi

AU - Poso, Antti

AU - Nevalainen, Tapio J.

AU - Parkkari, Teija

PY - 2015/1/25

Y1 - 2015/1/25

KW - Cannabinoid receptor

KW - CB2R agonists

KW - Triazines

KW - Radioligand

KW - ENDOCANNABINOID SYSTEM

KW - TYPE-2 RECEPTOR

KW - PET TRACER

KW - APOPTOSIS

KW - LIGANDS

KW - CELLS

KW - MELANOMA

KW - LEUKEMIA

KW - TARGETS

KW - 317 Pharmacy

KW - 116 Chemical sciences

U2 - 10.1016/j.ejps.2014.11.003

DO - 10.1016/j.ejps.2014.11.003

M3 - Article

VL - 67

SP - 85

EP - 96

JO - European Journal of Pharmaceutical Sciences

JF - European Journal of Pharmaceutical Sciences

SN - 0928-0987

ER -