Synthesis of 7β-hydroxy-8-ketone opioid derivatives with antagonist activity at mu- and delta-opioid receptors

Tiina J. Ahonen, Maiju Rinne, Peter Grutschreiber, Kert Mätlik, Mikko Airavaara, Dieter Schaarschmidt, Heinrich Lang, David Reiss, Henri Xhaard, Claire Gaveriaux-Ruff, Jari Yli-Kauhaluoma, Vania M. Moreira

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalEuropean Journal of Medicinal Chemistry
Volume151
Pages (from-to)495-507
Number of pages13
ISSN0223-5234
DOIs
Publication statusPublished - 10 May 2018
MoE publication typeA1 Journal article-refereed

Fields of Science

  • Morphine
  • Oxidation
  • Supported permanganate
  • Hydroxy ketone
  • Antagonist
  • Opioid receptor
  • HETEROGENEOUS PERMANGANATE OXIDATIONS
  • POTASSIUM-PERMANGANATE
  • SUPPORTED PERMANGANATE
  • BINDING-PROPERTIES
  • ORGANIC-COMPOUNDS
  • MORPHINE ANALOGS
  • OXIDIZING-AGENT
  • CODEINE
  • ACTIVATION
  • EFFICIENT
  • 317 Pharmacy

Cite this

@article{5366e4d3b9644c8c8723a1bd95c2640d,
title = "Synthesis of 7β-hydroxy-8-ketone opioid derivatives with antagonist activity at mu- and delta-opioid receptors",
keywords = "Morphine, Oxidation, Supported permanganate, Hydroxy ketone, Antagonist, Opioid receptor, HETEROGENEOUS PERMANGANATE OXIDATIONS, POTASSIUM-PERMANGANATE, SUPPORTED PERMANGANATE, BINDING-PROPERTIES, ORGANIC-COMPOUNDS, MORPHINE ANALOGS, OXIDIZING-AGENT, CODEINE, ACTIVATION, EFFICIENT, 317 Pharmacy",
author = "Ahonen, {Tiina J.} and Maiju Rinne and Peter Grutschreiber and Kert M{\"a}tlik and Mikko Airavaara and Dieter Schaarschmidt and Heinrich Lang and David Reiss and Henri Xhaard and Claire Gaveriaux-Ruff and Jari Yli-Kauhaluoma and Moreira, {Vania M.}",
year = "2018",
month = "5",
day = "10",
doi = "10.1016/j.ejmech.2018.02.074",
language = "English",
volume = "151",
pages = "495--507",
journal = "European Journal of Medicinal Chemistry",
issn = "0223-5234",
publisher = "ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER",

}

Synthesis of 7β-hydroxy-8-ketone opioid derivatives with antagonist activity at mu- and delta-opioid receptors. / Ahonen, Tiina J.; Rinne, Maiju; Grutschreiber, Peter; Mätlik, Kert; Airavaara, Mikko; Schaarschmidt, Dieter; Lang, Heinrich; Reiss, David; Xhaard, Henri; Gaveriaux-Ruff, Claire; Yli-Kauhaluoma, Jari; Moreira, Vania M.

In: European Journal of Medicinal Chemistry, Vol. 151, 10.05.2018, p. 495-507.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Synthesis of 7β-hydroxy-8-ketone opioid derivatives with antagonist activity at mu- and delta-opioid receptors

AU - Ahonen, Tiina J.

AU - Rinne, Maiju

AU - Grutschreiber, Peter

AU - Mätlik, Kert

AU - Airavaara, Mikko

AU - Schaarschmidt, Dieter

AU - Lang, Heinrich

AU - Reiss, David

AU - Xhaard, Henri

AU - Gaveriaux-Ruff, Claire

AU - Yli-Kauhaluoma, Jari

AU - Moreira, Vania M.

PY - 2018/5/10

Y1 - 2018/5/10

KW - Morphine

KW - Oxidation

KW - Supported permanganate

KW - Hydroxy ketone

KW - Antagonist

KW - Opioid receptor

KW - HETEROGENEOUS PERMANGANATE OXIDATIONS

KW - POTASSIUM-PERMANGANATE

KW - SUPPORTED PERMANGANATE

KW - BINDING-PROPERTIES

KW - ORGANIC-COMPOUNDS

KW - MORPHINE ANALOGS

KW - OXIDIZING-AGENT

KW - CODEINE

KW - ACTIVATION

KW - EFFICIENT

KW - 317 Pharmacy

U2 - 10.1016/j.ejmech.2018.02.074

DO - 10.1016/j.ejmech.2018.02.074

M3 - Article

VL - 151

SP - 495

EP - 507

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

SN - 0223-5234

ER -