Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues

Sami Kilpinen, Reija Autio, Kalle Ojala, Kristiina Iljin, Elmar Bucher, Henri Sara, Tommi Pisto, Matti Saarela, Rolf Skotheim, Mari Björkman, John-Patrick Mpindi, Saija Haapa-Paananen, Paula Vainio, Henrik Edgren, Maija Wolf, Jaakko Astola, Matthias Nees, Sampsa Hautaniemi, Olli Kallioniemi

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Our knowledge on tissue- and disease-specific functions of human genes is rather limited and highly context-specific. Here, we have developed a method for the comparison of mRNA expression levels of most human genes across 9,783 Affymetrix gene expression array experiments representing 43 normal human tissue types, 68 cancer types, and 64 other diseases. This database of gene expression patterns in normal human tissues and pathological conditions covers 113 million datapoints and is available from the GeneSapiens website.
Original languageEnglish
JournalGenome Biology
Volume9
Issue number9
Pages (from-to)1-14 (R139)
ISSN1474-760X
DOIs
Publication statusPublished - 2008
MoE publication typeA1 Journal article-refereed

Fields of Science

  • 311 Basic medicine
  • 312 Clinical medicine
  • 318 Medical biotechnology
  • 217 Medical engineering
  • 118 Biological sciences

Cite this

Kilpinen, Sami ; Autio, Reija ; Ojala, Kalle ; Iljin, Kristiina ; Bucher, Elmar ; Sara, Henri ; Pisto, Tommi ; Saarela, Matti ; Skotheim, Rolf ; Björkman, Mari ; Mpindi, John-Patrick ; Haapa-Paananen, Saija ; Vainio, Paula ; Edgren, Henrik ; Wolf, Maija ; Astola, Jaakko ; Nees, Matthias ; Hautaniemi, Sampsa ; Kallioniemi, Olli. / Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues. In: Genome Biology. 2008 ; Vol. 9, No. 9. pp. 1-14 (R139).
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title = "Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues",
abstract = "Our knowledge on tissue- and disease-specific functions of human genes is rather limited and highly context-specific. Here, we have developed a method for the comparison of mRNA expression levels of most human genes across 9,783 Affymetrix gene expression array experiments representing 43 normal human tissue types, 68 cancer types, and 64 other diseases. This database of gene expression patterns in normal human tissues and pathological conditions covers 113 million datapoints and is available from the GeneSapiens website.",
keywords = "311 Basic medicine, 312 Clinical medicine, 318 Medical biotechnology, 217 Medical engineering, 118 Biological sciences",
author = "Sami Kilpinen and Reija Autio and Kalle Ojala and Kristiina Iljin and Elmar Bucher and Henri Sara and Tommi Pisto and Matti Saarela and Rolf Skotheim and Mari Bj{\"o}rkman and John-Patrick Mpindi and Saija Haapa-Paananen and Paula Vainio and Henrik Edgren and Maija Wolf and Jaakko Astola and Matthias Nees and Sampsa Hautaniemi and Olli Kallioniemi",
year = "2008",
doi = "10.1186/gb-2008-9-9-r139",
language = "English",
volume = "9",
pages = "1--14 (R139)",
journal = "Genome Biology",
issn = "1474-7596",
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Kilpinen, S, Autio, R, Ojala, K, Iljin, K, Bucher, E, Sara, H, Pisto, T, Saarela, M, Skotheim, R, Björkman, M, Mpindi, J-P, Haapa-Paananen, S, Vainio, P, Edgren, H, Wolf, M, Astola, J, Nees, M, Hautaniemi, S & Kallioniemi, O 2008, 'Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues', Genome Biology, vol. 9, no. 9, pp. 1-14 (R139). https://doi.org/10.1186/gb-2008-9-9-r139

Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues. / Kilpinen, Sami; Autio, Reija; Ojala, Kalle; Iljin, Kristiina; Bucher, Elmar; Sara, Henri; Pisto, Tommi; Saarela, Matti; Skotheim, Rolf; Björkman, Mari; Mpindi, John-Patrick; Haapa-Paananen, Saija; Vainio, Paula; Edgren, Henrik; Wolf, Maija; Astola, Jaakko; Nees, Matthias; Hautaniemi, Sampsa; Kallioniemi, Olli.

In: Genome Biology, Vol. 9, No. 9, 2008, p. 1-14 (R139).

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues

AU - Kilpinen, Sami

AU - Autio, Reija

AU - Ojala, Kalle

AU - Iljin, Kristiina

AU - Bucher, Elmar

AU - Sara, Henri

AU - Pisto, Tommi

AU - Saarela, Matti

AU - Skotheim, Rolf

AU - Björkman, Mari

AU - Mpindi, John-Patrick

AU - Haapa-Paananen, Saija

AU - Vainio, Paula

AU - Edgren, Henrik

AU - Wolf, Maija

AU - Astola, Jaakko

AU - Nees, Matthias

AU - Hautaniemi, Sampsa

AU - Kallioniemi, Olli

PY - 2008

Y1 - 2008

N2 - Our knowledge on tissue- and disease-specific functions of human genes is rather limited and highly context-specific. Here, we have developed a method for the comparison of mRNA expression levels of most human genes across 9,783 Affymetrix gene expression array experiments representing 43 normal human tissue types, 68 cancer types, and 64 other diseases. This database of gene expression patterns in normal human tissues and pathological conditions covers 113 million datapoints and is available from the GeneSapiens website.

AB - Our knowledge on tissue- and disease-specific functions of human genes is rather limited and highly context-specific. Here, we have developed a method for the comparison of mRNA expression levels of most human genes across 9,783 Affymetrix gene expression array experiments representing 43 normal human tissue types, 68 cancer types, and 64 other diseases. This database of gene expression patterns in normal human tissues and pathological conditions covers 113 million datapoints and is available from the GeneSapiens website.

KW - 311 Basic medicine

KW - 312 Clinical medicine

KW - 318 Medical biotechnology

KW - 217 Medical engineering

KW - 118 Biological sciences

U2 - 10.1186/gb-2008-9-9-r139

DO - 10.1186/gb-2008-9-9-r139

M3 - Article

VL - 9

SP - 1-14 (R139)

JO - Genome Biology

JF - Genome Biology

SN - 1474-7596

IS - 9

ER -