Systematic identification of trans eQTLs as putative drivers of known disease associations

Harm-Jan Westra, Marjolein J. Peters, Tonu Esko, Hanieh Yaghootkar, Claudia Schurmann, Johannes Kettunen, Mark W. Christiansen, Benjamin P. Fairfax, Katharina Schramm, Joseph E. Powell, Alexandra Zhernakova, Daria V. Zhernakova, Jan H. Veldink, Leonard H. Van den Berg, Juha Karjalainen, Sebo Withoff, Andre G. Uitterlinden, Albert Hofman, Fernando Rivadeneira, Peter A. C. 't HoenEva Reinmaa, Krista Fischer, Mari Nelis, Lili Milani, David Melzer, Luigi Ferrucci, Andrew B. Singleton, Dena G. Hernandez, Michael A. Nalls, Georg Homuth, Matthias Nauck, Doerte Radke, Uwe Voelker, Markus Perola, Veikko Salomaa, Jennifer Brody, Astrid Suchy-Dicey, Sina A. Gharib, Daniel A. Enquobahrie, Thomas Lumley, Grant W. Montgomery, Seiko Makino, Holger Prokisch, Christian Herder, Michael Roden, Harald Grallert, Thomas Meitinger, Konstantin Strauch, Yang Li, Ritsert C. Jansen, Peter M. Visscher, Julian C. Knight, Bruce M. Psaty, Samuli Ripatti, Alexander Teumer, Timothy M. Frayling, Andres Metspalu, Joyce B. J. van Meurs, Lude Franke

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalNature Genetics
Volume45
Issue number10
Pages (from-to)1238-U195
Number of pages8
ISSN1061-4036
DOIs
Publication statusPublished - Oct 2013
MoE publication typeA1 Journal article-refereed

Fields of Science

  • GENOME-WIDE ASSOCIATION
  • GENE-EXPRESSION
  • LUPUS-ERYTHEMATOSUS
  • MYOCARDIAL-INFARCTION
  • SUSCEPTIBILITY LOCI
  • RISK
  • POPULATION
  • BLOOD
  • INTERFERON
  • VARIANTS
  • 3111 Biomedicine

Cite this

Westra, H-J., Peters, M. J., Esko, T., Yaghootkar, H., Schurmann, C., Kettunen, J., ... Franke, L. (2013). Systematic identification of trans eQTLs as putative drivers of known disease associations. Nature Genetics, 45(10), 1238-U195. https://doi.org/10.1038/ng.2756
Westra, Harm-Jan ; Peters, Marjolein J. ; Esko, Tonu ; Yaghootkar, Hanieh ; Schurmann, Claudia ; Kettunen, Johannes ; Christiansen, Mark W. ; Fairfax, Benjamin P. ; Schramm, Katharina ; Powell, Joseph E. ; Zhernakova, Alexandra ; Zhernakova, Daria V. ; Veldink, Jan H. ; Van den Berg, Leonard H. ; Karjalainen, Juha ; Withoff, Sebo ; Uitterlinden, Andre G. ; Hofman, Albert ; Rivadeneira, Fernando ; 't Hoen, Peter A. C. ; Reinmaa, Eva ; Fischer, Krista ; Nelis, Mari ; Milani, Lili ; Melzer, David ; Ferrucci, Luigi ; Singleton, Andrew B. ; Hernandez, Dena G. ; Nalls, Michael A. ; Homuth, Georg ; Nauck, Matthias ; Radke, Doerte ; Voelker, Uwe ; Perola, Markus ; Salomaa, Veikko ; Brody, Jennifer ; Suchy-Dicey, Astrid ; Gharib, Sina A. ; Enquobahrie, Daniel A. ; Lumley, Thomas ; Montgomery, Grant W. ; Makino, Seiko ; Prokisch, Holger ; Herder, Christian ; Roden, Michael ; Grallert, Harald ; Meitinger, Thomas ; Strauch, Konstantin ; Li, Yang ; Jansen, Ritsert C. ; Visscher, Peter M. ; Knight, Julian C. ; Psaty, Bruce M. ; Ripatti, Samuli ; Teumer, Alexander ; Frayling, Timothy M. ; Metspalu, Andres ; van Meurs, Joyce B. J. ; Franke, Lude. / Systematic identification of trans eQTLs as putative drivers of known disease associations. In: Nature Genetics. 2013 ; Vol. 45, No. 10. pp. 1238-U195.
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title = "Systematic identification of trans eQTLs as putative drivers of known disease associations",
keywords = "GENOME-WIDE ASSOCIATION, GENE-EXPRESSION, LUPUS-ERYTHEMATOSUS, MYOCARDIAL-INFARCTION, SUSCEPTIBILITY LOCI, RISK, POPULATION, BLOOD, INTERFERON, VARIANTS, 3111 Biomedicine",
author = "Harm-Jan Westra and Peters, {Marjolein J.} and Tonu Esko and Hanieh Yaghootkar and Claudia Schurmann and Johannes Kettunen and Christiansen, {Mark W.} and Fairfax, {Benjamin P.} and Katharina Schramm and Powell, {Joseph E.} and Alexandra Zhernakova and Zhernakova, {Daria V.} and Veldink, {Jan H.} and {Van den Berg}, {Leonard H.} and Juha Karjalainen and Sebo Withoff and Uitterlinden, {Andre G.} and Albert Hofman and Fernando Rivadeneira and {'t Hoen}, {Peter A. C.} and Eva Reinmaa and Krista Fischer and Mari Nelis and Lili Milani and David Melzer and Luigi Ferrucci and Singleton, {Andrew B.} and Hernandez, {Dena G.} and Nalls, {Michael A.} and Georg Homuth and Matthias Nauck and Doerte Radke and Uwe Voelker and Markus Perola and Veikko Salomaa and Jennifer Brody and Astrid Suchy-Dicey and Gharib, {Sina A.} and Enquobahrie, {Daniel A.} and Thomas Lumley and Montgomery, {Grant W.} and Seiko Makino and Holger Prokisch and Christian Herder and Michael Roden and Harald Grallert and Thomas Meitinger and Konstantin Strauch and Yang Li and Jansen, {Ritsert C.} and Visscher, {Peter M.} and Knight, {Julian C.} and Psaty, {Bruce M.} and Samuli Ripatti and Alexander Teumer and Frayling, {Timothy M.} and Andres Metspalu and {van Meurs}, {Joyce B. J.} and Lude Franke",
year = "2013",
month = "10",
doi = "10.1038/ng.2756",
language = "English",
volume = "45",
pages = "1238--U195",
journal = "Nature Genetics",
issn = "1061-4036",
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Westra, H-J, Peters, MJ, Esko, T, Yaghootkar, H, Schurmann, C, Kettunen, J, Christiansen, MW, Fairfax, BP, Schramm, K, Powell, JE, Zhernakova, A, Zhernakova, DV, Veldink, JH, Van den Berg, LH, Karjalainen, J, Withoff, S, Uitterlinden, AG, Hofman, A, Rivadeneira, F, 't Hoen, PAC, Reinmaa, E, Fischer, K, Nelis, M, Milani, L, Melzer, D, Ferrucci, L, Singleton, AB, Hernandez, DG, Nalls, MA, Homuth, G, Nauck, M, Radke, D, Voelker, U, Perola, M, Salomaa, V, Brody, J, Suchy-Dicey, A, Gharib, SA, Enquobahrie, DA, Lumley, T, Montgomery, GW, Makino, S, Prokisch, H, Herder, C, Roden, M, Grallert, H, Meitinger, T, Strauch, K, Li, Y, Jansen, RC, Visscher, PM, Knight, JC, Psaty, BM, Ripatti, S, Teumer, A, Frayling, TM, Metspalu, A, van Meurs, JBJ & Franke, L 2013, 'Systematic identification of trans eQTLs as putative drivers of known disease associations', Nature Genetics, vol. 45, no. 10, pp. 1238-U195. https://doi.org/10.1038/ng.2756

Systematic identification of trans eQTLs as putative drivers of known disease associations. / Westra, Harm-Jan; Peters, Marjolein J.; Esko, Tonu; Yaghootkar, Hanieh; Schurmann, Claudia; Kettunen, Johannes; Christiansen, Mark W.; Fairfax, Benjamin P.; Schramm, Katharina; Powell, Joseph E.; Zhernakova, Alexandra; Zhernakova, Daria V.; Veldink, Jan H.; Van den Berg, Leonard H.; Karjalainen, Juha; Withoff, Sebo; Uitterlinden, Andre G.; Hofman, Albert; Rivadeneira, Fernando; 't Hoen, Peter A. C.; Reinmaa, Eva; Fischer, Krista; Nelis, Mari; Milani, Lili; Melzer, David; Ferrucci, Luigi; Singleton, Andrew B.; Hernandez, Dena G.; Nalls, Michael A.; Homuth, Georg; Nauck, Matthias; Radke, Doerte; Voelker, Uwe; Perola, Markus; Salomaa, Veikko; Brody, Jennifer; Suchy-Dicey, Astrid; Gharib, Sina A.; Enquobahrie, Daniel A.; Lumley, Thomas; Montgomery, Grant W.; Makino, Seiko; Prokisch, Holger; Herder, Christian; Roden, Michael; Grallert, Harald; Meitinger, Thomas; Strauch, Konstantin; Li, Yang; Jansen, Ritsert C.; Visscher, Peter M.; Knight, Julian C.; Psaty, Bruce M.; Ripatti, Samuli; Teumer, Alexander; Frayling, Timothy M.; Metspalu, Andres; van Meurs, Joyce B. J.; Franke, Lude.

In: Nature Genetics, Vol. 45, No. 10, 10.2013, p. 1238-U195.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Systematic identification of trans eQTLs as putative drivers of known disease associations

AU - Westra, Harm-Jan

AU - Peters, Marjolein J.

AU - Esko, Tonu

AU - Yaghootkar, Hanieh

AU - Schurmann, Claudia

AU - Kettunen, Johannes

AU - Christiansen, Mark W.

AU - Fairfax, Benjamin P.

AU - Schramm, Katharina

AU - Powell, Joseph E.

AU - Zhernakova, Alexandra

AU - Zhernakova, Daria V.

AU - Veldink, Jan H.

AU - Van den Berg, Leonard H.

AU - Karjalainen, Juha

AU - Withoff, Sebo

AU - Uitterlinden, Andre G.

AU - Hofman, Albert

AU - Rivadeneira, Fernando

AU - 't Hoen, Peter A. C.

AU - Reinmaa, Eva

AU - Fischer, Krista

AU - Nelis, Mari

AU - Milani, Lili

AU - Melzer, David

AU - Ferrucci, Luigi

AU - Singleton, Andrew B.

AU - Hernandez, Dena G.

AU - Nalls, Michael A.

AU - Homuth, Georg

AU - Nauck, Matthias

AU - Radke, Doerte

AU - Voelker, Uwe

AU - Perola, Markus

AU - Salomaa, Veikko

AU - Brody, Jennifer

AU - Suchy-Dicey, Astrid

AU - Gharib, Sina A.

AU - Enquobahrie, Daniel A.

AU - Lumley, Thomas

AU - Montgomery, Grant W.

AU - Makino, Seiko

AU - Prokisch, Holger

AU - Herder, Christian

AU - Roden, Michael

AU - Grallert, Harald

AU - Meitinger, Thomas

AU - Strauch, Konstantin

AU - Li, Yang

AU - Jansen, Ritsert C.

AU - Visscher, Peter M.

AU - Knight, Julian C.

AU - Psaty, Bruce M.

AU - Ripatti, Samuli

AU - Teumer, Alexander

AU - Frayling, Timothy M.

AU - Metspalu, Andres

AU - van Meurs, Joyce B. J.

AU - Franke, Lude

PY - 2013/10

Y1 - 2013/10

KW - GENOME-WIDE ASSOCIATION

KW - GENE-EXPRESSION

KW - LUPUS-ERYTHEMATOSUS

KW - MYOCARDIAL-INFARCTION

KW - SUSCEPTIBILITY LOCI

KW - RISK

KW - POPULATION

KW - BLOOD

KW - INTERFERON

KW - VARIANTS

KW - 3111 Biomedicine

U2 - 10.1038/ng.2756

DO - 10.1038/ng.2756

M3 - Article

VL - 45

SP - 1238-U195

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 10

ER -

Westra H-J, Peters MJ, Esko T, Yaghootkar H, Schurmann C, Kettunen J et al. Systematic identification of trans eQTLs as putative drivers of known disease associations. Nature Genetics. 2013 Oct;45(10):1238-U195. https://doi.org/10.1038/ng.2756