Systematic mapping of cancer cell target dependencies using high-throughput drug screening in triple-negative breast cancer

Tianduanyi Wang; Prson Gautam; Juho Rousu; Tero Aittokallio

doi:10.1016/j.csbj.2020.11.001

Systematic mapping of cancer cell target dependencies using high-throughput drug screening in triple-negative breast cancer

Tianduanyi Wang, Prson Gautam, Juho Rousu, Tero Aittokallio

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Computational and Structural Biotechnology Journal
Volume	18
Pages (from-to)	3819-3832
Number of pages	14
ISSN	2001-0370
DOIs	https://doi.org/10.1016/j.csbj.2020.11.001
Publication status	Published - 2020
MoE publication type	A1 Journal article-refereed

Fields of Science

Target addiction
Cancer vulnerability
Functional dependency
Gene essentiality
Drug screening
Multi-targeted treatments
EXPRESSION
POLYPHARMACOLOGY
DECONVOLUTION
OPPORTUNITIES
SENSITIVITY
CHALLENGES
ADDICTION
EFFICACY
1182 Biochemistry, cell and molecular biology

Access to Document

10.1016/j.csbj.2020.11.001

1-s2.0-S2001037020304682-mainFinal published version, 3.79 MBLicence: CC BY-NC-ND

Cite this

@article{8daf036868af4444b333f759b20bace6,

title = "Systematic mapping of cancer cell target dependencies using high-throughput drug screening in triple-negative breast cancer",

keywords = "Target addiction, Cancer vulnerability, Functional dependency, Gene essentiality, Drug screening, Multi-targeted treatments, EXPRESSION, POLYPHARMACOLOGY, DECONVOLUTION, OPPORTUNITIES, SENSITIVITY, CHALLENGES, ADDICTION, EFFICACY, 1182 Biochemistry, cell and molecular biology",

author = "Tianduanyi Wang and Prson Gautam and Juho Rousu and Tero Aittokallio",

year = "2020",

doi = "10.1016/j.csbj.2020.11.001",

language = "English",

volume = "18",

pages = "3819--3832",

journal = "Computational and Structural Biotechnology Journal",

issn = "2001-0370",

publisher = "Chalmers University of Technology",

}

TY - JOUR

T1 - Systematic mapping of cancer cell target dependencies using high-throughput drug screening in triple-negative breast cancer

AU - Wang, Tianduanyi

AU - Gautam, Prson

AU - Rousu, Juho

AU - Aittokallio, Tero

PY - 2020

Y1 - 2020

KW - Target addiction

KW - Cancer vulnerability

KW - Functional dependency

KW - Gene essentiality

KW - Drug screening

KW - Multi-targeted treatments

KW - EXPRESSION

KW - POLYPHARMACOLOGY

KW - DECONVOLUTION

KW - OPPORTUNITIES

KW - SENSITIVITY

KW - CHALLENGES

KW - ADDICTION

KW - EFFICACY

KW - 1182 Biochemistry, cell and molecular biology

U2 - 10.1016/j.csbj.2020.11.001

DO - 10.1016/j.csbj.2020.11.001

M3 - Article

SN - 2001-0370

VL - 18

SP - 3819

EP - 3832

JO - Computational and Structural Biotechnology Journal

JF - Computational and Structural Biotechnology Journal

ER -